Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

Oh, Chung-Sik; Kim, Karam; Kang, Woon Seok; Woo, Nam Sik; Kang, Po Soon; Kim, Jun Seok; Kim, Hang Rae; Lee, Seung Hyun; Kim, Seong-Hyop

doi:10.1038/s41598-018-28505-8

Cited by 5 publications

(3 citation statements)

References 31 publications

(31 reference statements)

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“…The evidence of a stronger perioperative effect of IL-10 on circulating monocytes in the Propofol group is also supported by the presence of higher Propofol-induced variations of the first sextile-based HLA-DR low fractions, in particular at T2 and T4. These preliminary flow cytometric monocyte-derived data seem to be in accord with previous clinical observations demonstrating both a higher systemic anti-inflammatory effect, during and after CPB surgery, of a Propofol-based anesthesia in comparison with Sevoflurane, 21,22 and a Propofol dose-dependent induction of IL-10 plasma release during CPB. 23…”

Section: Discussionsupporting

confidence: 90%

Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study

et al. 2019

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Introduction: The increase of the anti-inflammatory CD163highHLA-DRlow blood monocyte subset is one of the mechanisms dampening inflammation during cardiac surgery with cardiopulmonary bypass. We evaluated the effect of two different anesthetic protocols, intravenous Propofol infusion or Sevoflurane-gas administration, on the perioperative frequency of this subset. Methods: Blood from patients (Propofol = 11, Sevoflurane = 13) undergoing minimally invasive mitral valve surgery was drawn preoperatively (T1), before declamping (T2), at 6 (T3), 24 (T4), 48 (T5), and 72 hours (T6) after declamping. C-reactive protein, haptoglobin, and lactate dehydrogenase were measured. A hemolytic index, as C-reactive protein/haptoglobin ratio, was introduced. Monocyte expression of HLA-DR, CD163, and the CD163highHLA-DRlow subset fraction was quantified by flow cytometry. Baseline-referred variations of plasmatic and cellular data at T2 were normalized for clamping times. Subsequent time-point variations were normalized for the final cardiopulmonary bypass times. Results: Variations of hemolytic index and lactate dehydrogenase were higher with Propofol at T3 (p = 0.004 and p = 0.02, respectively) when compared with Sevoflurane. At T2, the down-modulation of CD163 was higher with Propofol (p = 0.005). Starting from T3, the up-regulatory trend of CD163 was basically higher with Propofol, although not significantly. Propofol induced higher increments of HLA-DR low fractions, at T2 (p = 0.04) and, to a lesser extent, at T4 (p = 0.06). Starting from T3, the CD163highHLA-DRlow subset variations were higher with Propofol, especially at T4 and T6. Conclusion: Propofol seems to induce a higher postoperative fraction of the CD163highHLA-DRlow monocyte subset. This could represent either a compensatory mechanism dampening the higher inflammatory condition observed with Propofol at T2 or a consequence of a higher postoperative Propofol-induced hemolysis.

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Section: Discussionsupporting

confidence: 90%

Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study

et al. 2019

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“…Inhaled sevoflurane in contrast provides sufficient sedation during PP and fast awakening that allows the patient to actively participate in his therapy and recovery. Besides a well-controllable sedative effect, sevoflurane provides a number of side effects that seem to be beneficial for the treatment of patients with CARDS [35][36][37]: These include bronchodilating [38], anti-inflammatory [39] and, in theory, cardioprotective effects [40,41]. However, cardioprotective effects have not yet been clinically demonstrated [42].…”

Section: Clinical Significancementioning

confidence: 99%

Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning

Bansbach¹,

Wenz²,

Kaufmann³

et al. 2022

ait

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Coronavirus disease 2019 (COVID-19) is associated with respiratory impairment by multifocal pneumonitis. The most severe expression, when acute respiratory distress syndrome (ARDS) is present, is termed CARDS (COVID-19-ARDS). Prolonged prone positioning (PP) is an established treatment for patients with ARDS [1][2][3][4]. PP provides various effects leading to pulmonary recruitment and improvement of oxygenation [3].Most patients require analgesia and sedation to tolerate prolonged PP. Even in the supine position control of dyspnoea when applying "lung protective" ventilation parameters is facilitated and may result in desperate "air hunger" in COVID-19 patients [5].

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“…Furthermore, regulator T cells, tumor-associated macrophages and myeloidderived suppressor cells (MDSCs) recruited by cancer cells also favor tumor progression (22). Propofol attenuated the decrease in CD39 and CD73 in circulating CD4+ T cells compared to sevoflurane-based anesthesia in patients undergoing open heart surgeries (23), while similar comparative studies have not been reported in breast cancer patients despite that circulating regulatory T cells has been recently reported to be significantly increased in breast cancer patients which may impact on the stage and histological type of breast cancer (24). The possible mechanisms of propofol and sevoflurane on anticancer immunity, breast cancer cell proliferation, migration and apoptosis are summarized in Figures 1 and 2.…”

Section: Immune Pathogenesis Of Tumorigenesismentioning

confidence: 99%

Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review

et al. 2022

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Perioperative interventions produce substantial biologic perturbations which are associated with the risk of recurrence after cancer surgery. The changes of tumor microenvironment caused by anesthetic drugs received increasing attention. Till now, it’s still unclear whether or not anesthetic drugs may exert positive or negative impact on cancer outcomes after surgery. Breast cancer is the most common tumor and the leading cause of cancer deaths in women. Propofol and sevoflurane are respectively the most commonly used intravenous and inhaled anesthetics. Debates regarding which of the two most commonly used anesthetics may relatively contribute to the recurrence and metastasis vulnerability of breast cancer postoperatively remain. This review aimed to provide a comprehensive view about the effect of propofol versus sevoflurane on the prognosis of breast cancer obtained from pre-clinical studies and clinical studies. Laboratory and animal studies have demonstrated that sevoflurane may enhance the recurrence and metastasis of breast cancer, while propofol is more likely to reduce the activity of breast cancer cells by attenuating the suppression of the immune system, promoting tumor cells apoptosis, and through other direct anti-tumor effects. However, retrospective clinical studies have shown contradictory results about the effects of propofol and sevoflurane on long-term survival in breast cancer patients. Furthermore, recent prospective studies did not identify significant differences between propofol and sevoflurane in breast cancer metastasis and recurrence. Therefore, more preclinical studies and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients.

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Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

Cited by 5 publications

References 31 publications

Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study

Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study

Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning

Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review

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