Comparison of the expression and function of Lin28A and Lin28B in colon cancer

Wang, Tianzhen; He, Yan; Zhu, Yuanyuan; Chen, Mingwei; Weng, Mingjiao; Yang, Chao; Zhang, Yan; Ning, Ning; Zhao, Ruihua; Yang, Weiwei; Jin, Yinji; Li, Jing; Redpath, Riju James Rajkumar Ezakiel; Zhang, Lei; Jin, Xiaoming; Zhong, Zhaohua; Zhang, Fengmin; Wei, Yunwei; Shen, Guomin; Wang, Dong; Liu, Ying; Wang, Guangyu; Li, Xiaobo

doi:10.18632/oncotarget.12869

Cited by 27 publications

(28 citation statements)

References 21 publications

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“…LIN28A overexpression is associated with tumor progression in colon cancer [ 39 ]. LIN28A was found to be upregulated in breast cancer and enhanced tumor growth and progression via regulation of c-myc signaling; LIN28A knockdown decreased tumor malignancy [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549

et al. 2017

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Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.

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Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549

et al. 2017

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“…Lin28B belongs to the Lin28 protein family, including its paralog Lin28A [23] . Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions [23] .…”

Section: Discussionmentioning

confidence: 99%

“…Lin28B belongs to the Lin28 protein family, including its paralog Lin28A [23] . Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions [23] . It is worth noting that one major difference between Lin28A and Lin28B is that Lin28B predominantly resides in the nucleus, whereas Lin28A exclusively resides in the cytoplasm [24] .…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B

Liu

et al. 2017

Acta Pharmacol Sin

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Previous studies have shown that the expression of microRNA-4458 (miR-4458) is dysregulated in hepatocellular carcinoma and colon cancer. In this study, we investigated the direct target of miR-4458 and its biological functions in human lung cancer cells. By using the database TargetScan, we identified Lin28B, an oncogene, as a direct target gene of miR-4458. In dual-luciferase reporter assay, we found that miR-4458 mimics dose-dependently inhibited the luciferase activity of the wild-type 3'UTR of Lin28B in human lung cancer A549 and NCI-H1299 cell lines without affecting its mutant forms, whereas anti-miR-4458, an inhibitor of miR-4458, dose-dependently promoted the luciferase activity of the wild-type 3'UTR of Lin28B in A549 and NCI-H1299 cell lines without affecting its mutant forms. Overexpression of miR-4458 significantly decreased the protein levels of Lin28B in the cells, and inhibited the cell growth and colony formation. Conversely, knockdown of miR-4458 with anti-miR-4458 significantly increased the protein levels of Lin28B, and promoted the cell proliferation, which could be reverted by knockdown of Lin28B expression. In addition, we detected the expression of Lin28B using RT-PCR in 40 human lung cancer tissues and matched peritumoral tissues, and found that Lin28B was overexpressed in lung cancer tissues and negatively correlated with miR-4458 expression (r=-0.694, P<0.05). We conclude that miR-4458 is a tumor suppressor, and Lin28B is the direct target of miR-4458. These results suggest the modulation of miR-4458/Lin28B expression offers a potential therapeutic strategy for lung cancer.

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“…Silencing of LIN28B in CRC cells induced apoptosis via upregulating let‐7c‐targeting of antiapoptotic BCL2L1 (H. Zhang et al, ). LIN28A was also upregulated in ~70% of CRC patients, which promoted progression of the disease (Tu et al, ; T. Wang et al, ). Taken together, LIN28 proteins appear to be crucial for colorectal tumorigenesis through the biogenesis of let‐7 miRNAs and posttranscriptional regulation of oncogenic mRNAs.…”

Section: Major Functions Of Rbps In Gi Cancermentioning

confidence: 99%

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

Masuda

Kuwano

2018

WIREs RNA

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Gene expression patterns in cancer cells are strongly influenced by posttranscriptional mechanisms. RNA-binding proteins (RBPs) play key roles in posttranscriptional gene regulation; they can interact with target mRNAs in a sequence-and structure-dependent manner, and determine cellular behavior by manipulating the processing of these mRNAs. Numerous RBPs are aberrantly deregulated in many human cancers and hence, affect the functioning of mRNAs that encode proteins, implicated in carcinogenesis. Here, we summarize the key roles of RBPs in posttranscriptional gene regulation, describe RBPs disrupted in cancer, and lastly focus on RBPs that are responsible for implementing cancer traits in the digestive tract. These evidences may reveal a potential link between changes in expression/function of RBPs and malignant transformation, and a framework for new insights and potential therapeutic applications.

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Comparison of the expression and function of Lin28A and Lin28B in colon cancer

Cited by 27 publications

References 21 publications

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549

Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549

MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

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