Comparison of the efficiency of different antibiotic irrigation solutions in decontamination of allografts contaminated with Staphylococcus aureus

Kaya, İbrahim; Sungur, İbrahim; Yılmaz, Murat; Pehlivanoğlu, Filiz; Kartyaşar, Kadriye; Şengöz, Gönül

doi:10.3944/aott.2013.3114

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Kaya et al[ 30 ] examined the decontaminating effects of RF, gentamicin, fusidic acid, and salinecontaining irrigation solutions on bone allografts contaminated with S. aureus and reported that the RF-containing solution exhibited the highest level of effectiveness. Apart from their beneficial impact on decontamination, there are concerns regarding the potential effects of antibiotics on wound and bone healing in orthopedic surgeries.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and histomorphometric investigation of the effects of different irrigation solutions on Achilles tendon healing in rats

Mahsut Dincel,

Can,

Karabag

2023

Jt Dis Relat Surg

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Objectives This study aimed to examine the effect of irrigation fluids containing povidone-iodine (PVP-I), rifampicin (RF), and chlorhexidine gluconate (CHG) used during surgery on healing on a rat Achilles tendon model. Materials and methods Twenty-eight male Sprague-Dawley rats (range, 300 to 400 g) were used in the experiment carried out between November 2022 and December 2022. The rats were divided into PVP-I, RF, CHG, and control groups, with seven rats in each group. Following the tenotomy and repair of the right Achilles tendon, the surgical site was irrigated using PVP-I, RF, CHG, or normal saline (the control group) for 2 min. All rats were sacrificed on the 21 st postoperative day. The samples were evaluated histomorphometrically using the scoring system modified by Svensson, Soslowsky, and Cook and histopathologically using the Bonar and Movin classifications. Results The RF group gave better results in all three scoring systems compared to the control, PVP-I, and CHG groups (p=0.008, p=0.002, and p=0.006, respectively). Cellularity, rounding, and tenocyte morphology showed a significant difference in favor of the RF group (p=0.004). While the distribution of ground substance glycosaminoglycans showed a significant difference in favor of the RF group, there was no significant difference among the other groups (p=0.22). Conclusion Irrigation solutions containing PVP-I, RF, or CHG show no negative effect on Achilles tendon healing. Moreover, the findings suggest that RF irrigation can accelerate the healing process.

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Section: Discussionmentioning

confidence: 99%