Objective: Hand antisepsis has an important place in the prevention of surgical site infections. In this review, we aimed to systematically examine the studies on the comparison between the efficiency of surgical hand washing method and the antiseptics being used. Methods: Between August 2009 and September 2014, 23,450 studies which were published were screened. The databases of "EBSCO", "Pubmed", "Medline", "Cochrane Library", "Science Direct," "Google Academic" and "ULAKBIM" were screened by using the keywords "Surgical hand washing" "comparison of surgical hand scrubbing solutions" and "operating room". Among the acquired studies, only 14 randomized-controlled (RC) and experimental articles were examined. These articles were given in a chronological order containing the authors, years, titles, objectives, samples, methods, findings, discussions and conclusions. Results: Considering the findings that were acquired according to this systematic examination, we observed that majority of studies preferred alcohol-based washing products instead of traditional hand washing products (scrubbing with a soap or a povidone iodine), as traditional methods causes less and even no complications such as hand cracks and scrapes, saves time and, above all, it shows an antibacterial effect in a short time. Recent experimental studies suggest that scrubbing fingernails and hands with an antiseptic solution has no use in surgical decontamination; thus, it is sufficient to scrub until the hand dries and the most efficient alcohol-based hand washing product is chlorhexidine gluconate. Efficiency of antiseptics used in surgical hand washing differs according to the technique of surgical hand washing and the sample group being used. Conclusion: Procurement of surgical hand antisepsis is one of the most important principles in preventing the surgical site infections. Efficiency and preference of surgical hand washing solutions is still a disputable issue. Thus, it is recommended to repeat relevant randomized-controlled and experimental studies in a different sample group.