Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia

İnce, Bilsev; Yıldırım, Mehmet; Dadacı, Mehmet; Avunduk, Mustafa Cihat; Savacı, Nedim

doi:10.1007/s00266-017-1004-y

Cited by 31 publications

(18 citation statements)

References 17 publications

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“…This could partly account for such large variations in the end concentration of growth factors in PRP for different subjects. There has been at least one attempt to use homologous PRP in place of autologous PRP for treating hair loss . Such an approach may overcome low platelet count issues in some patients and would also provide an on‐demand treatment without the need for in‐clinic PRP processing, though the safety and jurisdiction regulatory status of such an approach is open to question.…”

Section: Discussionmentioning

confidence: 99%

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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Background Platelet‐rich plasma (PRP), processed from autologous peripheral blood, is used to treat androgenetic alopecia (AGA). Objective To determine the efficacy of PRP for hair growth promotion in AGA patients in a randomized, blinded, placebo‐controlled, pilot clinical trial (NCT02074943). Methods The efficacy of an 8 week, five session, PRP treatment course was determined by measuring hair density and hair caliber changes in 10 AGA affected patients. For each PRP sample, the concentrations of selected growth factors were determined using a multiplex assay system. The clinical results were then correlated with the growth factor concentrations in PRP. Results At 16 weeks, 8 weeks after the last PRP injection, treated areas exhibited increased mean hair density (+12.76%) over baseline compared to placebo (+0.99%). Mean hair caliber decreased in both treated and placebo regions (−16.22% and −19.46%, respectively). Serial analysis of PRP significant variability in concentrations between patients. Overall, there was a positive correlation between GDNF concentration and hair density (P = .004). Trends, though not statistically significant, were also observed for FGF2 and VEGF. Limitations Small sample size and lack of comparative cohorts receiving protocol variations limit confidence in the study data. Conclusions This small pilot clinical trial suggests PRP treatment may be beneficial for AGA. However, the variable hair growth responses between patients indicate there is a significant opportunity to improve PRP therapy protocols for hair growth promotion. The variability in growth factor concentration in PRP suggests standardization of growth factors postprocessing might improve hair growth responses.

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Section: Discussionmentioning

confidence: 99%

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Siah

Guo

Chu

et al. 2020

Experimental Dermatology

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“…Photoaging mainly impacts the conversion of synthetic collagen fibers to synthetic elastic fibers, as well as inflammatory infiltration of the dermis (2). UV-irradiation of skin induces elevated matrix metalloproteinase (MMP) expression, leading to degradation of fibrous connective tissue and reduction of collagen synthesis, and these biological processes are important mechanisms of skin photoaging (3)(4)(5). In addition, tyrosinase is a key enzyme that initiates melanogenesis and tyrosinase activity strongly correlates with melanin production (6).…”

Section: Introductionmentioning

confidence: 99%

Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Lei

2020

Exp Ther Med

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Autologous serum platelet-rich plasma (PRP) has been used to rejuvenate wrinkled and aged skin for years; however, the molecular mechanism for the positive effects of PRP on the skin remains unclear. The present study aimed to clarify the potential molecular mechanisms for the role of PRP in wrinkled and aged skin rejuvenation, and provide evidence for future clinical applications. A total of 30 healthy females were recruited for PRP treatment and signed informed consent was obtained. A total of 3 autologous PRP injections were administered to each patient with 15-day intervals between injections. The effects of PRP injections were evaluated using the VISIA ® Complexion Analysis System and skin computed tomography. A human organotypic skin model was established and treated with PBS or PRP before ultraviolet (UV)-B light (10 mJ/cm 2) irradiation. The distribution of the epidermal structure and dermal fibers were analyzed by hematoxylin and eosin and Masson's trichome staining. Expression of matrix metalloproteinase-1 (MMP-1), tyrosinase, fibrillin and tropoelastin was detected by reverse transcription-quantitative PCR, western blotting and immunofluorescence. The present results showed that PRP treatment improved skin quality in the participants. In addition, the VISIA ® results showed that wrinkles, texture and pores were decreased in the PRP groups compared with the PBS treatment. The in vitro study demonstrated that PRP treatment ameliorated photoaging by inhibiting UV-B-induced MMP-1 and tyrosinase upregulation, and by inducing fibrillin and tropoelastin expression that was downregulated by UV-B. Collectively, it was demonstrated that PRP treatment ameliorated skin photoaging through regulation of MMP-1, tyrosinase, fibrillin and tropoelastin expression.

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“…Such a response can even occur in case of fresh h-PRP samples. Several studies have reported clinical applications of h-PRP in various diseased conditions like osteoarthritis, periodontal disease, and others [5,7,15]. Despite the presence of same blood type in the recipient and donor, an incompatibility is still possible in the examination of fresh h-PRP crossmatch test.…”

Section: Resultsmentioning

confidence: 99%

Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test

et al. 2020

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Platelet-rich plasma (PRP) rich in growth factors has evolved as an important therapy for periodontal tissue regeneration. A healthy blood donors obtained for homologous PRP (h-PRP). The Freeze-drying h-PRP sample provides an effective method to ensure a longer shelf-life. The h-PRP samples are subjected to crossmatch testing in clinics to prevent any immune response in recipients. The present study aimed to evaluate the differences in donor compatibility on crossmatch test results towards fresh and freeze-dried h-PRP (FD h-PRP). This was a laboratory experiment, h-PRP prepared according to the protocol of blood bank, and 40 recipients blood samples divided into two groups, fresh h-PRP (control group) and FD h-PRP. The crossmatch test was performed to evaluate h-PRP compatibilities by using the gel-test method. The data were analyzed using the chi-square test. The results of the study showed that the crossmatch test on FD h-PRP samples was 100 % compatible and could increase the compatibility results of the donor. the FD h-PRP was safe to become donors and clinical applications.

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Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Cited by 31 publications

References 17 publications

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation

Differences in donor compatibility for fresh and freeze-dried homologous platelet rich plasma studied using crossmatch test

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