Comparison of the efficacy of a demand oxygen delivery system with continuous low flow oxygen in subjects with stable COPD and severe oxygen desaturation on walking.

Roberts, C M; Bell, Jake; Wedzicha, JA

doi:10.1136/thx.51.8.831

Cited by 60 publications

(51 citation statements)

References 16 publications

(2 reference statements)

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“…This study concluded that oxygen-conserving devices vary in their ability to maintain S pO 2 during exercise. Roberts et al 22 found PF with a pulse volume of 35 mL with a pulse time of 200 ms to be equivalent to CF at 2 L/min. During the 6-min walk test, PF performed worse than CF (S pO 2 78% vs 81%).…”

Section: Discussionmentioning

confidence: 99%

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Zhou

Chatburn

2014

Respir Care

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BACKGROUND: The F IO 2 for a nasal cannula with constant flow (CF) depends on the anatomic reservoir (AR), which is affected by changes in frequency and end-expiratory flow. Conversely, pulse flow (PF) devices do not require the AR. The purpose of this study was to compare the F IO 2 delivered by a nasal cannula supplied by CF via oxygen tank with that delivered by PF delivered via portable oxygen concentrator. Hypotheses were (1) a lung model of COPD with non-zero end-expiratory flow decreases F IO 2 for CF more than for PF, and (2) CF and PF perform differently in terms of F IO 2 delivery, despite having equivalent settings. METHODS: Normal and COPD lung models were simulated (IngMar Medical ASL 5000) using published human data: normal: breathing frequency ‫؍‬ 15 breaths/min, R in ‫؍‬ 4 cm

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Section: Discussionmentioning

confidence: 99%

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Zhou

Chatburn

2014

Respir Care

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“…Another explanation for the failure of LTOT to reduce hospitalisation when compared with placebo, could be a substantial effect of placebo. Several studies have found that placebo (sham oxygen) improves dyspnoea and exercise tolerance [17,18].…”

Section: Discussionmentioning

confidence: 99%

Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease?

Ringbæk¹,

Viskum²,

Lange³

2002

European Respiratory Journal

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Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease? T.J. Ringbaek, K. Viskum, P. Lange. #ERS Journals Ltd 2002. ABSTRACT: The aim of this study was to determine whether long-term oxygen therapy (LTOT) reduces hospitalisation in hypoxaemic patients with chronic obstructive pulmonary disease (COPD). The circumstances of initiation of LTOT (start during hospitalisation versus start as an outpatient) and compliance with oxygen were also investigated (continuous oxygen therapy (COT) o15 h daily versus noncontinuous oxygen therapy (NCOT) v15 h daily).A total 246 COPD patients were studied, with each patient acting as their own control. Patients were divided into four groups: 125 patients on COT who started LTOT in conjunction with hospitalisation, 37 patients on COT who started LTOT as outpatients, 58 patients on NCOT who started LTOT in conjunction with hospitalisation and 26 patients on NCOT who started LTOT as outpatients. Admission rates, days spent in hospital and number of patients with at least one hospitalisation (ever hospitalised) were compared in two periods of 10 months before and after initiation of LTOT.Overall during the LTOT period, in comparison with the preoxygen period, the admission rates, hospital days and "ever hospitalised" were reduced by 23.8%, 43.5% and 31.2%, respectively. Among patients who started LTOT as outpatients, a tendency towards a higher effect in the compliant group was observed.This study shows that in hypoxaemic chronic obstructive pulmonary disease patients, long-term oxygen therapy is associated with a reduction in hospitalisation. Eur Respir J 2002; 20: 38-42.

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“…When the patient is at rest, the 2 types of systems have proven to be equivalent. [9][10][11] However, when oxygen requirements increase, specifically during exercise [10][11][12][13][14][15][16] and in patients with ILD, 17 oxygenconserving devices do not seem to provide equivalent benefits.…”

Section: Introductionmentioning

confidence: 99%

Are Oxygen-Conserving Devices Effective for Correcting Exercise Hypoxemia?

Martí

Pajares²,

Morante³

et al. 2013

Respir Care

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BACKGROUND: Correction of exercise hypoxemia in advanced lung diseases is crucial and often challenging. However, oxygen-conserving devices have been introduced in the market with limited evidence of effectiveness. In the present study the efficacy of 2 oxygen-conserving devices, a pulse demand oxygen delivery (DOD) system and pendant reservoir cannula (PRC), were evaluated in subjects with COPD and interstitial lung disease (ILD). METHODS: A cross-sectional, crossover study included 28 COPD and 31 ILD subjects with oxygen desaturation on the 6-min walk test (average S pO 2 < 88%). Each subject underwent 3 walk tests with DOD, PRC, and continuous oxygen flow by standard nasal cannula (CFNC), in random order, taking average S pO 2 > 90% as the resaturation criterion. RESULTS: Exercise desaturation was corrected in 79%, 79%, and 86% of COPD subjects with CFNC, DOD, and PRC, respectively, and in 77%, 61%, and 81% of ILD subjects with CFNC, DOD, and PRC, respectively. When compared to CFNC, the oxygen-conserving devices showed similar efficacy, except a lower performance for the DOD in the ILD subjects (P ‫؍‬ .01). CONCLUSIONS: Although these oxygen-conserving devices corrected exercise hypoxemia in most COPD and ILD subjects, correction was not achieved in about 20% of the severe COPD subjects, regardless of the device, and in nearly 40% of the ILD subjects with the DOD device. These findings underscore that individualized adjustment of oxygen flow is needed for optimal correction of exercise hypoxemia, especially with a DOD in an ILD patient. (Clinical Trials.gov NCT01086891).

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Comparison of the efficacy of a demand oxygen delivery system with continuous low flow oxygen in subjects with stable COPD and severe oxygen desaturation on walking.

Cited by 60 publications

References 16 publications

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Effect of the Anatomic Reservoir on Low-Flow Oxygen Delivery Via Nasal Cannula: Constant Flow Versus Pulse Flow With Portable Oxygen Concentrator

Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease?

Are Oxygen-Conserving Devices Effective for Correcting Exercise Hypoxemia?

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