Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in  experimental animals with peritonitis

Yıldırım, Mehmet Aykut; Çakır, Murat; Fındık, Sıddıka; Kişi, Ömer; Şentürk, Mustafa

doi:10.1007/s12664-020-01145-5

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In summary, the utilization of collagen during colorectal surgery has been associated with a noticeable increase in vascular proliferation and fibroblastic activity. Studies conducted in a high-risk mice model have demonstrated a substantial enhancement in vascular proliferation and fibroblastic activity following the application of collagen during colorectal surgery [ 28 ]. Ongoing research is dedicated to investigating the use of collagen to improve bowel function recovery after colorectal resection and anastomosis.…”

Section: Discussionmentioning

confidence: 99%

Collagen patch cover facilitates recovery of bowel function after laparoscopic colectomy

Huang,

Tsai,

Kiu

et al. 2024

BMC Surg

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Background Numerous factors can influence bowel movement recovery and anastomotic healing in colorectal surgery, and poor healing can lead to severe complications and increased medical expenses. Collagen patch cover (CPC) is a promising biomaterial that has been demonstrated to be safe in animal models and has been successfully applied in various surgical procedures in humans. This study. Methods A retrospective review of medical records from July 2020 to June 2022 was conducted to identify consecutive patients who underwent laparoscopic colectomy. Patients who received CPC at the anastomotic site were assigned to the collagen group, whereas those who did not receive CPC were assigned to the control group. Results Data from 241 patients (collagen group, 109; control group, 132) were analyzed. Relative to the control group, the collagen group exhibited a faster recovery of bowel function, including an earlier onset of first flatus (2.93 days vs. 3.43 days, p < 0.01), first defecation (3.73 days vs. 4.18 days, p = 0.01), and oral intake (4.30 days vs. 4.68 days, p = 0.04). CPC use was also associated with lower use of postoperative intravenous analgesics. The complication rates in the two groups did not differ significantly. Conclusions CPCs can be safely and easily applied to the anastomotic site during laparoscopic colectomy, and can accelerate bowel movement recovery. Further studies on the effectiveness of CPCs in colorectal surgery involving larger sample sizes are required. Clinical trial registration ClinicalTrials.gov registration number: NCT05831956 (26/04/2023).

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Section: Discussionmentioning

confidence: 99%

Collagen patch cover facilitates recovery of bowel function after laparoscopic colectomy

Huang,

Tsai,

Kiu

et al. 2024

BMC Surg

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“…Collagen is the most important factor in anastomosis healing, which correlates with elevation in hydroxyproline levels. In this hypothesis generating study from Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey, the authors assessed tissue hydroxyproline levels biochemically assessing wound healing in three groups of seven Wistar albino rats -a control, fibroblast growth factor collagen (FGF-C) group, and the antibiotic collagen (AB-C) group [15]. After a surgical defect distal to the ileocecal junction, a primary anastomosis was performed 24 h later.…”

Section: Comparison Of the Efficacy Of Growth Factor Collagen And Antibiotic Collagen On Colon Anastomosis In Peritonitis Abdomenmentioning

confidence: 99%

Editorial commentary on the Indian Journal of Gastroenterology– May–June 2021

Limdi

2021

Indian J Gastroenterol

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Serum C-reactive protein and neutrophil to lymphocyte ratio as predictors of survival in cirrhotic patients with systemic inflammatory response syndrome and bacterial infection Patients with liver cirrhosis are at risk of significant morbidity and mortality from infectious complications [1]. Data on biochemical surrogates as predictors of infection are scarce. Tapadia et al. from Gleneagles Global Health City, Chennai, India assessed the predictive value of C-reactive protein (CRP) and the neutrophil-lymphocyte ratio (NLR) alone and in combination in predicting infection in a cohort of 208 consecutive hospitalized patients with cirrhosis [2].In addition to standard assessments (laboratory, ultrasound and appropriate cultures), CRP and NLR were also obtained. Investigators noted an infection rate of 62% with 58.5% culture positivity and mortality of 30.8%. Optimal cut-off values for NLR and CRP to predict infection were 5.86 and 33.7, respectively. One-month mortality risk was 2-3 times with NLR and CRP above these cut-off values. The combination of NLR + CRP (≥5.86 and ≥ 33.7) increased specificity and diagnostic accuracy for infection suggesting that these may have a role in predicting infection and even culture positivity. Prospective controlled studies are needed to validate this interesting observation.

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Wound Coating Collagen-Based Composites with Ag Nanoparticles: Synthesis, Structure and Biological Activity

et al. 2023

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The search for materials for a new generation of wound coatings is important due to the increase in antibiotic-resistant microorganisms and the number of patients with untreatable chronic purulent wounds. Metal nanoparticles, specifically silver nanoparticles, have antimicrobial activity and do not induce known bacterial resistance. To obtain new Ag-containing nanocomposites, type I collagen was extracted by an enzyme–acid method from cattle tendons. Silver nanoparticles were obtained by an environmentally safe method, metal-vapor synthesis (MVS), which enables obtaining metal nanoparticles without impurities. For this, metal vapors were cocondensed in a vacuum of 10−2 Pa on the walls of a quartz reactor cooled to 77 K using acetone as an organic dispersion medium. The composition of the collagen surface was determined by XPS using the spectra of C1s, N1s, and O1s. The presence of a peak with a binding energy of approximately 368.57 eV in the Ag 3d5/2 spectrum indicates the state of Ag0 silver atoms in the nanocomposite. SEM images showed that collagen contributes to the effective stabilization of Ag nanoparticles with an average size of 13.0 ± 3.5 nm. It was found that collagen is non-toxic and biocompatible with skin cells and fibroblasts. The collagen–Ag nanoparticle nanocomposites exhibited antimicrobial activity against bacteria Bacillus subtilis, Escherichia coli, and fungi Aspergillus niger.

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Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitis

Cited by 3 publications

References 26 publications

Collagen patch cover facilitates recovery of bowel function after laparoscopic colectomy

Collagen patch cover facilitates recovery of bowel function after laparoscopic colectomy

Editorial commentary on the Indian Journal of Gastroenterology– May–June 2021

Wound Coating Collagen-Based Composites with Ag Nanoparticles: Synthesis, Structure and Biological Activity

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