“…Six completed RCTs [ 16 , 34 - 38 ], with a total of 152 patients, with ages ranging from 15 to 25 years, were included in this SR. One study included only female patients [ 36 ], three studies did not give information about sex distribution [ 16 , 34 , 35 ], while the other two studies included both genders, with a predominance of females [ 37 , 38 ]. Four of the involved studies were of a compound design (COMP) [a parallel-group design with a split-mouth design (SMD) in each group] [ 16 , 34 , 35 , 38 ], and the others were of SMD [ 36 , 37 ]. Three studies touched on the multiplicity of acceleration methods.…”