Comparison of the efficacy of a Tabernaemontana divaricata extract and of biosynthesized silver nanoparticles in preventing cataract formation in an in-vivo system of selenite-induced cataractogenesis

Anbukkarasi, Muniyandi; Thomas, Philip A.; Teresa, P. Archana; Anand, T.; Geraldine, Pitchairaj

doi:10.1016/j.bcab.2019.101475

Cited by 7 publications

(9 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In selenite-challenged Wistar rat pups, the same AgNPs prevented cataractogenesis by maintaining calcium homeostasis (regulation of lenticular ATPases activity, regulation of genes encoding calcium transporter proteins) which is essential for the integrity of lenticular structural and cytoskeletal proteins. In the same study, chemically synthesized AgNPs showed insignificant anticataractogenic effects [ 16 ]. AgNPs synthesized using an aqueous extract of Turbinaria conoides , a brown seaweed, showed heart and liver regeneration effects in zebrafish ( Danio rerio ) as revealed by histological studies [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

et al. 2023

View full text Add to dashboard Cite

In recent years, phytofunctionalized AgNPs have attracted great interest due to their remarkable biological activities. In the present study, AgNPs were synthesized using Abies alba and Pinus sylvestris bark extracts. The chemical profile of these bark extracts was analyzed by LC-HRMS/MS. As a first step, the synthesis parameters (pH, AgNO3 concentration, ratio of bark extract and AgNO3, temperature, and reaction time) were optimized. The synthesized AgNPs were characterized by ATR-FTIR spectroscopy, DLS, SEM, EDX, and TEM. Their antioxidant, cytotoxic, and antibacterial properties were evaluated by the DPPH, ABTS, MTT, and broth microdilution assays, respectively. Abies alba and Pinus sylvestris bark extract-derived AgNPs were well-dispersed, spherical, small (average particle size of 9.92 and 24.49 nm, respectively), stable (zeta potential values of −10.9 and −10.8 mV, respectively), and cytotoxic to A-375 human malignant melanoma cells (IC50 = 2.40 ± 0.21 and 6.02 ± 0.61 μg/mL, respectively). The phytosynthesized AgNPs also showed antioxidant and antibacterial effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It is highly probable that these nanoparticles could be regularly used in various sectors, such as medical, cosmetic, and food applications [ 256 ]. In another study conducted by Anbukkarasi et al [ 267 ], T. divaricata extracts were used for biosynthesizing nanoparticles and the resulting biosynthesized nanoparticles were tested in vivo to prevent the formation of cataracts in selenite-induced cataractogenesis in Wistar rat pups [ 267 ]. It was revealed that rats induced with AgNps treatment displayed a reduction in lenticular alterations compared to plant extract-treated rats [ 267 ].…”

Section: Major Bioactive Components and Biological Activities Of mentioning

confidence: 99%

“…In another study conducted by Anbukkarasi et al [ 267 ], T. divaricata extracts were used for biosynthesizing nanoparticles and the resulting biosynthesized nanoparticles were tested in vivo to prevent the formation of cataracts in selenite-induced cataractogenesis in Wistar rat pups [ 267 ]. It was revealed that rats induced with AgNps treatment displayed a reduction in lenticular alterations compared to plant extract-treated rats [ 267 ]. The results of the study recommend that biosynthesized AgNps using T. divaricata extracts may provide limitations of selenite-induced cataractogenesis in vivo, while simultaneous sustaining standard lenticular calcium homeostasis by avoiding adjustments in important lenticular proteins [ 267 ].…”

Section: Major Bioactive Components and Biological Activities Of mentioning

confidence: 99%

“…It was revealed that rats induced with AgNps treatment displayed a reduction in lenticular alterations compared to plant extract-treated rats [ 267 ]. The results of the study recommend that biosynthesized AgNps using T. divaricata extracts may provide limitations of selenite-induced cataractogenesis in vivo, while simultaneous sustaining standard lenticular calcium homeostasis by avoiding adjustments in important lenticular proteins [ 267 ].…”

Section: Major Bioactive Components and Biological Activities Of mentioning

confidence: 99%

See 1 more Smart Citation

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

Naidoo

Dewir

et al. 2021

Plants

View full text Add to dashboard Cite

Several species belonging to the genus Tabernaemontana have been well researched and utilized for their wide-ranging biological activities. A few of the most prominent species include Tabernaemontana divaricata, Tabernaemontana catharinensis, Tabernaemontana crassa, and Tabernaemontana elegans. These species and many others within the genus often display pharmacological importance, which is habitually related to their chemical constituents. The secondary metabolites within the genus have demonstrated huge medicinal potential for the treatment of infections, pain, injuries, and various diseases. Regardless of the indispensable reports and properties displayed by Tabernaemontana spp., there remains a wide variety of plants that are yet to be considered or examined. Thus, an additional inclusive study on species within this genus is essential. The current review aimed to extensively analyze, collate, and describe an updated report of the current literature related to the major alkaloidal components and biological activities of species within the genus Tabernaemontana.

show abstract

“…Plant extracts act not only as reducing and/or capping agents, but also as modulators of the biological effects of nanosized metallic Ag [ 5 ]. Thus, AgNPs synthesized using plant extracts or pure phytochemicals have been reported to develop a wide range of biological activities, such as antibacterial, antifungal and antiviral [ 6 ], anti-inflammatory [ 7 ], antioxidant [ 5 , 7 ], wound healing [ 8 ], anticancer [ 1 , 3 ], anticoagulant [ 9 ], cardioprotective [ 10 ], liver protective [ 10 ], antidiabetic [ 11 ], anti-cataractogenic [ 12 ] and anti-ageing [ 13 ] activities.…”

Section: Introductionmentioning

confidence: 99%

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

et al. 2021

View full text Add to dashboard Cite

Silver nanoparticles synthesized using plant extracts as reducing and capping agents showed various biological activities. In the present study, colloidal silver nanoparticle solutions were produced from the aqueous extracts of Picea abies and Pinus nigra bark. The phenolic profile of bark extracts was analyzed by liquid chromatography coupled to mass spectrometry. The synthesis of silver nanoparticles was monitored using UV-Vis spectroscopy by measuring the Surface Plasmon Resonance band. Silver nanoparticles were characterized by attenuated total reflection Fourier transform infrared spectroscopy, Raman spectroscopy, dynamic light scattering, scanning electron microscopy, energy dispersive X-ray and transmission electron microscopy analyses. The antimicrobial and cytogenotoxic effects of silver nanoparticles were evaluated by disk diffusion and Allium cepa assays, respectively. Picea abies and Pinus nigra bark extract derived silver nanoparticles were spherical (mean hydrodynamic diameters of 78.48 and 77.66 nm, respectively) and well dispersed, having a narrow particle size distribution (polydispersity index values of 0.334 and 0.224, respectively) and good stability (zeta potential values of −10.8 and −14.6 mV, respectively). Silver nanoparticles showed stronger antibacterial, antifungal, and antimitotic effects than the bark extracts used for their synthesis. Silver nanoparticles obtained in the present study are promising candidates for the development of novel formulations with various therapeutic applications.

show abstract

Comparison of the efficacy of a Tabernaemontana divaricata extract and of biosynthesized silver nanoparticles in preventing cataract formation in an in-vivo system of selenite-induced cataractogenesis

Cited by 7 publications

References 53 publications

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

Silver Nanoparticles Synthesized from Abies alba and Pinus sylvestris Bark Extracts: Characterization, Antioxidant, Cytotoxic, and Antibacterial Effects

Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)

Phyto-Functionalized Silver Nanoparticles Derived from Conifer Bark Extracts and Evaluation of Their Antimicrobial and Cytogenotoxic Effects

Contact Info

Product

Resources

About