Comparison of The Efficacy of Topical Tranexamic Acid and Oxymetazoline Following Q-Switched 1064 Nm Nd: YAG Laser for The Treatment of Post Acne Erythema: A Split-Face, Controlled Trial

Abstract

Background: Post acne erythema is a common complication of acne with no gold standard treatment. Unfortunately, complete clearance of acne erythema may not always be achieved, therefore it is a therapeutic challenge. Aim: To compare the efficacy of Q-switched 1064 nm Nd:YAG laser when combined with topical OXZ on the right half and topical TXA on the left half for PAE. Methods: A controlled trial was conducted with 30 patients having PAE recruited from the outpatient clinic of Dermatology, department of Benha University Hospitals. All patients were subjected to Q switched Nd:YAG laser followed by topical treatment using split face model: OXZ on the right half and TXA on the left one. This regimen was repeated three times at a 2-weeks interval. Outcomes were assessed by digital photography. Results: The count and the grade of PAE on the two sides of the face were significantly improved after the end of both treatments compared to the baseline. Pain, and erythema were the most frequently reported adverse effects. Conclusion: A new effective combination of Q-switched 1064 nm Nd:YAG laser with topical vasoconstrictors regimen either TXA or OXZ has a promising role in PAE treatment with fewer side effects for PAE.