Comparison of the efficacy of different biodegradable membranes in guided bone/tissue regeneration: a systematic review and network meta-analysis

Zhou, Zili; Yun, Jiahao; Li, Jie; Chen, Yimeng; Duan, Tingting; Wang, Liqiao; Han, Jianmin; Jiang, Heng Bo; Niu, Guang Liang

doi:10.1088/1748-605x/acc99a

Cited by 3 publications

(1 citation statement)

References 137 publications

(265 reference statements)

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“…Owing to their unique characteristic of directly forming a solid membrane or matrix within the defect, cross‐linkable hydrogels have been introduced to streamline the clinical handling of GBR 5 . Studies have reported that self‐setting polyethylene glycol is as efficacious as a collagen membrane in treating bony dehiscence defects surrounding dental implants 6 .…”

Section: Introductionmentioning

confidence: 99%

Bone regeneration with hydroxyapatite particles loaded in photo‐cross‐linkable hydrogel: An experimental study

Li,

Guo,

Choi

et al. 2024

J Biomed Mater Res

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This study explores the use of in situ cross‐linked hyaluronic acid methacryloyl (HAMA) and hydroxyapatite particles (HAP) for bone defect repair. Human periodontal ligament stem cells (PDLSCs) were isolated and co‐cultured with the HAMA‐HAP composite. Osteogenic differentiation was evaluated using Alizarin Red staining, alkaline phosphatase activity quantification, and polymerase chain reaction (PCR). A cranial defect was induced in Sprague–Dawley rats. This defect was then filled with the HAMA‐HAP composite and cross‐linked using UV light exposure. Bone formation was assessed through radiographic and histological analyses. The HAMA‐HAP composite was found to promote cell viability similarly to pure HAP. It also enhanced gene expression of ALP, OPN, and Runx2, and increased ALP activity and mineralized nodule formation in vitro. Micro‐CT scans showed defect restoration in the HAMA‐HAP and HAP groups compared to the control group. The HAMA‐HAP group exhibited higher Tb.N, Tb.Sp, Tb.Th, and BV/TV. Masson staining showed the HAMA‐HAP composite restored the defect site, with new bone formation thicker than in the HAP group. The HAMA‐HAP composite showed excellent biocompatibility and promoted osteogenic differentiation of PDLSCs. It effectively repaired cranial defects, indicating its potential for clinical use in bone defect repair.

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Section: Introductionmentioning

confidence: 99%

Bone regeneration with hydroxyapatite particles loaded in photo‐cross‐linkable hydrogel: An experimental study

Li,

Guo,

Choi

et al. 2024

J Biomed Mater Res

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Improving chitosan-based composite membrane by introducing a novel hybrid functional nano-hydroxyapatite with carboxymethyl cellulose and phytic acid

Jiang,

Ma,

Tang

et al. 2024

Front. Chem. Sci. Eng.

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A comprehensive in vitro characterization of non-crosslinked, diverse tissue-derived collagen-based membranes intended for assisting bone regeneration

Barrino,

Vassallo,

Cammarota

et al. 2024

PLoS ONE

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Collagen-based membranes are class III-medical devices widely used in dental surgical procedures to favour bone regeneration. Here, we aimed to provide biophysical and biochemical data on this type of devices to support their optimal use and design/manufacturing. To the purpose, four commercial, non-crosslinked collagen-based-membranes, obtained from various sources (equine tendon, pericardium or cortical bone tissues, and porcine skin), were characterized in vitro. The main chemical, biophysical and biochemical properties, that have significant clinical implications, were evaluated. Membranes showed similar chemical features. They greatly differed in morphology as well as in porosity and density and showed a diverse ranking in relation to these latter two parameters. Samples highly hydrated in physiological medium (swelling-ratio values in the 2.5–6.0 range) and, for some membranes, an anisotropic expansion during hydration was, for the first time, highlighted. Rheological analyses revealed great differences in deformability (150-1500kPa G’) also alerting about the marked variation in membrane mechanical behaviour upon hydration. Samples proved diverse sensitivity to collagenase, with the cortical-derived membrane showing the highest stability. Biological studies, using human-bone-derived cells, supported sample ability to allow cell proliferation and to prompt bone regeneration, while no relevant differences among membranes were recorded. Prediction of relative performance based on the findings was discussed. Overall, results represent a first wide panel of chemical/biophysical/biochemical data on collagen-based-membranes that 1) enhances our knowledge of these products, 2) aids their optimal use by providing clinicians with scientific basis for selecting products based on the specific clinical situation and 3) represents a valuable reference for optimizing their manufacturing.

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Comparison of the efficacy of different biodegradable membranes in guided bone/tissue regeneration: a systematic review and network meta-analysis

Cited by 3 publications

References 137 publications

Bone regeneration with hydroxyapatite particles loaded in photo‐cross‐linkable hydrogel: An experimental study

Bone regeneration with hydroxyapatite particles loaded in photo‐cross‐linkable hydrogel: An experimental study

Improving chitosan-based composite membrane by introducing a novel hybrid functional nano-hydroxyapatite with carboxymethyl cellulose and phytic acid

A comprehensive in vitro characterization of non-crosslinked, diverse tissue-derived collagen-based membranes intended for assisting bone regeneration

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