Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi‐centre, double‐blind, randomized, placebo‐controlled study

Abstract

Bilastine 20 mg is a novel effective and safe treatment option for the management of CU.

Comparative inhibition by bilastine and cetirizine of histamine-induced wheal and flare responses in humans

“…The efficacy of bilastine is supported by preclinical studies in vitro and in experimental animals in vivo showing bilastine to be a potent H 1 -antihistamine [12,13]. It is also supported by a study of 525 patients with chronic idiopathic urticaria in which 20 mg of bilastine once daily was of similar efficacy to 5 mg levocetirizine [14]. Furthermore, in the nose, bilastine has been shown to be of comparable efficacy to both 10 mg cetirizine [16] and 5 mg desloratadine [17].…”

“…In a study of 525 patients with chronic idiopathic urticaria, bilastine 20 mg once daily significantly (P \ 0.001 compared with placebo) relieved the symptoms. Furthermore, the overall efficacy results demonstrated that bilastine was of similar efficacy to levocetirizine [14]. In the nose, a double-blind cross-over study in which 75 allergic volunteers were challenged with grass pollen in the Vienna Challenge Chamber showed bilastine to be equally effective as cetirizine and fexofenadine but the results obtained suggest that it has a longer duration than fexofenadine [15], while in two 14-day trials in seasonal allergic rhinitis, bilastine was shown to be of similar efficacy to daily dosage with 10 mg cetirizine and 5 mg desloratadine [16,17].…”

Histamine and H1-antihistamines: Celebrating a century of progress

“…In contrast, high-quality trials of second-generation H 1 -antihistamines, such as cetirizine, desloratadine, fexofenadine, levocetirizine, loratadine, bilastine, and rupatadine confirm that they decrease symptoms and improve quality of life (see Table E2). 42,48,[65][66][67][68][69] Although many patients respond to standard doses of these medications, more respond to increasing the daily dose up to 4-fold; for example, in one double-blind randomized controlled trial, 13 of 40 patients became symptom free on 5 mg of levocetirizine and 28 of the 40 patients became symptom free on 10 or 20 mg of levocetirizine without experiencing adverse effects at the higher doses. Additionally, in objective tests, such as in patients with acquired cold urticaria, high-dose desloratadine (20 mg) or rupatadine (20 mg) decrease wheal volume and improve cold provocation thresholds significantly compared with standard doses.…”

Antihistamines in Treatment of Chronic Urticaria. Review of Modern Recommendations

“…В двух многоцентровых РКИ на фоне 4-6-недельной терапии фексофенадином в дозах 120 и 180 мг/сут у 324 и 254 пациентов с хро-нической крапивницей достоверно улучшалось качество жизни по шкале DLQI и продуктивность в сравнении с плацебо [43]. Биластин 20 мг и левоцетиризин 5 мг в многоцентровом исследовании пациентов с хрониче-ской крапивницей показали изменения на 9,45 и 8,94 балла соответственно против 5,93 балла на плацебо, с наибольшим влиянием на уменьшение общего диском-форта и нарушений сна [44].…”