Comparison of the Efficacy and Safety of Trandolapril and Nifedipine SR in Mild-to-Moderate Hypertension

Steiner, Genevieve Z.; Pauly, N. C.

doi:10.1097/00005344-199400234-00016

Cited by 6 publications

(1 citation statement)

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“…23,24 In non-placebo-controlled studies, the rates of edema with dihydropyridine CCBs ranged from 5% to 28% with nifedipine, [25][26][27][28][29] 2% to 32% with amlodipine, 29 -34 0% to 30% with felodipine, 24,26,30,[35][36][37][38][39] 8% to 14% with isradipine, 37,40 8% to 15% with nicardipine, 41 19% with nisoldipine, 42 6% with lacdipine, 43 and 5% to 17% with nitrendipine. 44,45 Two non-placebocontrolled studies, one using nifedipine and the other isradipine, did not report edema as an adverse event.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Fluid Matters in Choosing Antihypertensive Therapy: A Hypothesis That the Data Speak Volumes

Blankfield

2005

The Journal of the American Board of Family Medicine

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Assuming that blood pressure is lowered equivalently, diuretics are more effective than angiotensinconverting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), and ␣-adrenergic receptor blockers (␣-blockers) at preventing heart failure, and they are more effective than ACEIs and ␣-blockers at preventing strokes. Compared with ␤-adrenergic receptor blockers (␤-blockers) and ACEIs, CCBs are less effective at reducing myocardial infarcts and heart failure. There is currently no conceptual framework by which to organize data indicating that some antihypertensive medications are better than others at preventing cardiovascular diseases. The thesis of this article is that the fluid reduction or fluid retention attributable to antihypertensive medications, either alone or in combination, provides a basis for ranking these medications. Diuretics have a theoretical advantage compared with other antihypertensive medications because they reduce total body fluid more than other agents. Therefore, they are the preferred drugs for treating hypertension. Provided that blood pressure is lowered comparably, diuretics have been demonstrated to be more effective than angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), and ␣-adrenergic receptor blockers (␣-blockers) at preventing heart failure, and diuretics have been found to be more effective than ACEIs and ␣-blockers at preventing stokes.

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