Comparison of the efficacy and safety between a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser and a conventional Q-switched 532-nm laser for the treatment of cafe-au-lait macules in 40 Chinese children: a prospective, randomized, parallel-controlled, evaluator-blinded trial

Zhuang, Yin; Huang, Minghuan; Shen, Jinwen; Wang, Lei; Yang, Liping; Jiang, Aifang; Yao, Zhirong; Yu, Xia

doi:10.1007/s10103-021-03245-w

Cited by 6 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The uneven pigmentation rate in our study was higher on the conventional HFQS 755‐nm laser‐treated side than on the other side, indicating that the LFQS 1064‐nm laser is more appropriate for an even and gradual change in lesion appearance. Our uneven pigmentation rate was higher than previous study (9.5%, 2/21) of Zhang's 11 . That may be because Zhang used conventional QS 532‐nm laser with larger spot, lower fluence which can make the lesion color even.…”

Section: Discussioncontrasting

confidence: 68%

“…17 Several studies have reported the use of the LFQS 1064-nm laser in the treatment of CALMs with good results and low side effects (Supporting Information: Table 2). [8][9][10][11][12] This prospective, self-controlled study confirmed that the overall effectiveness of LFQS 1064-nm laser and conventional HFQS 755-nm laser in the treatment of CALMs within 3 months were not significantly different. But 11 lesions treated with LFQS 1064-nm laser and 7 treated with HFQS 755-nm laser were included in the Tertile 3 group (3.67 ≤ VAS ≤ 4), suggesting that within 3 months, the LFQS 1064-nm laser may help more patients achieve the top-third of efficacy.…”

Section: Discussionsupporting

confidence: 65%

“…Our uneven pigmentation rate was higher than previous study (9.5%, 2/21) of Zhang's. 11 That may be because Zhang used conventional QS 532-nm laser with larger spot, lower fluence which can make the lesion color even.…”

Section: Discussionmentioning

confidence: 99%

“…7 Since then, several studies have reported the good effect and low recurrence rate (0%−24.1%) of the LFQS 1064-nm laser in the treatment of CALMs. [8][9][10][11][12][13] However, the most popular lasers used currently are the QS 755-nm laser and QS 532-nm laser. Our study confirmed these had similar efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…In 2009, Kim first used LFQS 1064‐nm laser to successfully treat a patient with CALM that could not be effectively removed by previous laser, grinding, and bleaching treatments 7 . Since then, several studies have reported the good effect and low recurrence rate (0%−24.1%) of the LFQS 1064‐nm laser in the treatment of CALMs 8–13 . However, the most popular lasers used currently are the QS 755‐nm laser and QS 532‐nm laser.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of the safety and efficacy of low fluence Q‐switched 1064‐nm and conventional Q‐Switched 755‐nm lasers in the treatment of café‐au‐lait macules: A prospective self‐controlled trial

et al. 2022

View full text Add to dashboard Cite

Background Conventional high fluence Q‐switched (HFQS) Alexandrite 755‐nm are widely used in clinical café‐au‐lait macules (CALMs) treatment. There have been recent concerns regarding the efficacy and safety of low fluence Q‐switched (LFQS) Nd: YAG 1064‐nm lasers. Objective To evaluate the efficacy and safety of the conventional HFQS and LFQS laser in the treatment of CALMs. Methods Within 3 months, 20 patients underwent prospective self‐controlled split‐lesion treatments with HFQS once or twice depending on the recovery rate, and with LFQS six times biweekly. Then the more effective laser was selected for continued treatments. Efficacy outcomes were evaluated by a visual analog scale (VAS) biweekly during the comparative trail. Recovery process, side effects and recurrence were recorded during the trial and follow‐up visit. Patient and physician preferences for laser selection were also recorded. Results The average VAS scores of areas treated with HFQS and LFQS were 2.92 ± 0.86 and 2.93 ± 1.13, respectively (p > 0.05). The most significant efficacy change of LFQS was after the fourth laser treatment (VAS score: 1.82−2.37, p < 0.001). 11 lesions treated with LFQS and 7 with HFQS achieved an optimal treatment response (3.67 ≤ VAS ≤ 4). Three patients relapsed on one side (one on LFQS, two on HFQS) and five on both sides. Adverse effects included temporary hypopigmentation, hyperpigmentation, uneven pigmentation, and mottled hypopigmentation. Doctors thought 80% of patients were suitable for LFQS. 70% of patients preferred LFQS posttreatment. Conclusions The efficacy difference between the LFQS 1064‐nm laser and HFQS 755‐nm laser in treating CALMs in a 3‐month comparative trial was statistically insignificant. LFQS is preferred by doctors and patients and is likely to help more patients achieve treatment efficacy than the HFQS within a short time, with fewer temporary adverse reactions, and a more even pigmentation. But it can cause mottled hypopigmentation. The LFQS had obvious lesion clearance after the fourth treatment.

show abstract

Section: Discussioncontrasting

confidence: 68%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of the safety and efficacy of low fluence Q‐switched 1064‐nm and conventional Q‐Switched 755‐nm lasers in the treatment of café‐au‐lait macules: A prospective self‐controlled trial

et al. 2022

View full text Add to dashboard Cite

show abstract

Update on lasers in pediatric dermatology: how primary care providers can help patients and families navigate appropriate treatment options and timelines

Osborn

Nieman

2023

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of review The use of lasers in pediatric dermatology is well established, but recent literature has expanded the evidence for specific timelines of treatment. Additionally, new devices and combinations with medical therapy have improved outcomes and treatment options for various conditions. Recent findings Pulsed dye laser remains the first-line laser for vascular lesions. Recent guidelines support early initiation of laser treatment in port-wine birthmarks to optimize outcomes. For hemangiomas, laser treatment can offer a meaningful addition to oral propranolol therapy. Lasers with shorter wavelengths offer improved outcomes with decreased downtime for pigmented lesions. General anesthesia in the pediatric population continues to be a controversial topic, and the decision to perform laser under general versus topical anesthesia requires discussion with family of risks and benefits. Summary Primary care providers can benefit their patients by prompt referral to dermatology for discussion of laser treatment. Port-wine birthmarks require referral in the first weeks of life so that laser treatment can be initiated if appropriate. Although many dermatologic conditions cannot be completely cleared or cured with laser, treatment can offer meaningful outcomes and benefit for patients and families.

show abstract

Five hundred and thirty‐two‐nanometer Q ‐switched Nd:Yag laser with larger fractional spot: A novel and safe technique to treat C afé au lait macule—A case report

Lodi

Fasano

Nisticò

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

Cited by 6 publications

References 24 publications

Comparison of the safety and efficacy of low fluence Q‐switched 1064‐nm and conventional Q‐Switched 755‐nm lasers in the treatment of café‐au‐lait macules: A prospective self‐controlled trial

Comparison of the safety and efficacy of low fluence Q‐switched 1064‐nm and conventional Q‐Switched 755‐nm lasers in the treatment of café‐au‐lait macules: A prospective self‐controlled trial

Update on lasers in pediatric dermatology: how primary care providers can help patients and families navigate appropriate treatment options and timelines

Five hundred and thirty‐two‐nanometer Q ‐switched Nd:Yag laser with larger fractional spot: A novel and safe technique to treat C afé au lait macule—A case report

Contact Info

Product

Resources

About