Comparison of the effects of imidapril and enalapril in a prospective, multicentric randomized trial in dogs with naturally acquired heart failure

Amberger, Chris; Chetboul, Valérie; Bomassi, Eric; Rougier, Sandrine; Woehrle, Frédérique; Thoulon, Fabrice

doi:10.1016/s1760-2734(06)70053-4

Cited by 25 publications

(34 citation statements)

References 10 publications

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“…All these studies were prospective, placebo-controlled (except the FIRST study [17] which compared imidapril to enalapril), double-blinded, multicentric, and randomized. The initial studies were shortterm clinical trials with treatment lasting 3 to 4 weeks [18,19].…”

Section: Experimental Studiesmentioning

confidence: 99%

“…In these studies, the clinical endpoints were clinical variables. The subsequent trials were long-term studies for assessing survival times [17,20,21,22].…”

Section: Experimental Studiesmentioning

confidence: 99%

“…Most of the dogs with chronic valvular disease enrolled in the trials were small breed dogs. The most represented breeds (when indicated in the publications) were the Poodle in the COVE study (22%) [19], the LIVE Study (28%) [20] and the BENCH Study [21], and the Cavalier King Charles Spaniel in the Scandinavian Veterinary Enalapril Prevention Trial (100%) [22] and the FIRST study (14%) [17]. Within the dogs with dilated cardiomyopathy, the breeds with highest representation were the Doberman Pinscher in the COVE study (56%) [19] and the LIVE study (56%) [20], and Boxers (14%) in the BENCH study [21].…”

Section: Overall Characteristics Of the Canine Population Used In CLImentioning

confidence: 99%

“…The different classifications are shown in Table 4. The efficacy of ACE inhibitors was compared to placebo treatment, except in the FIRST study [17] and the study by Morisse and Kersten [25,26], in which comparison between ACE inhibitors was performed. In most trials, other conventional therapy for CHF treatment (especially furosemide with or without digoxin) was given.…”

Section: Overall Characteristics Of the Canine Population Used In CLImentioning

confidence: 99%

“…In the BENCH study [21], 54% of the dogs received diuretics and 22% were given digoxin, and only about 10% of the dogs received just benazepril. In the FIRST study [17], 47% of the dogs received furosemide, digoxin or both. In the study by Kitagawa et al [23] and the Scandinavian Veterinary Enalapril Prevention Trial [22], only monotherapy with the ACE inhibitor was performed.…”

Section: Overall Characteristics Of the Canine Population Used In CLImentioning

confidence: 99%

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Angiotensin-Converting Enzyme Inhibitors in Veterinary Medicine

Lefebvre¹,

Brown²,

Chetboul³

et al. 2007

CPD

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Angiotensin-converting enzyme (ACE) inhibitors represent one of the most commonly used categories of drugs in canine and feline medicine. ACE inhibitors currently approved for use in veterinary medicine are benazepril, enalapril, imidapril and ramipril. They are all pro-drugs administered by oral route. A physiologically based model taking into account the saturable binding to ACE has been developed for pharmacokinetic analysis. The bioavailability of the active compounds from their respective pro-drug is low. The active metabolites are eliminated by renal, hepatorenal or biliary excretion, according to the drug. The elimination half-life of the free fraction of the active compounds is very short (ranging from approximately 10 min to 2 h). ACE inhibitors are generally well tolerated. Benazepril, enalapril, imidapril and ramipril are approved for dogs with chronic heart failure (CHF). The efficacy of ACE inhibitors has been convincingly demonstrated in dogs with CHF, especially in those with chronic valvular disease. In such clinical settings, ACE inhibitors improve hemodynamics and clinical signs, and increase survival time. In cats with cardiovascular disease, little information is available except for reports of some benefit in cats with hypertrophic cardiomyopathy in two non-controlled investigations. ACE inhibitors have also a mild to moderate hypotensive effect. There is also evidence to recommend ACE inhibitors in dogs and cats with chronic renal failure (CRF). They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of CRF and to limit the extent of renal lesions.

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Section: Experimental Studiesmentioning

confidence: 99%

“…In these studies, the clinical endpoints were clinical variables. The subsequent trials were long-term studies for assessing survival times [17,20,21,22].…”

Section: Experimental Studiesmentioning

confidence: 99%