Comparison of the Effects of Dobutamine and Milrinone on Hemodynamic Parameters and Oxygen Supply in Patients Undergoing Cardiac Surgery with Low Cardiac Output after Anesthetic Induction

Carmona, Maria José Carvalho; Martins, Laura M.; Vane, Matheus Fachini; Longo, B.; Paredes, Lemuel Silva; Malbouisson, Luíz Marcelo Sá

doi:10.1016/s0034-7094(10)70032-5

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…Milrinone has been successfully used in the treatment of septic shock paediatric patients with normal or low cardiac output [50]. In patients with low cardiac output after cardiotomy, milrinone was equally effective in increasing systemic blood flow when compared to dobutamine and in patients with severe heart failure and low cardiac output [51] a recent small study reported no exacerbation of myocardial injury as assessed by measurements of biomarkers of myocardial injury and inflammation [52]. However, the use of milrinone has been associated with new onset arrhythmias e.g.…”

Section: Resultsmentioning

confidence: 99%

Hemodynamic Treatment Aimed to Reduce Catecholamine Toxicity in Patients Suffering from Septic Shock: An Observational Single Center Study

Hartjes

2013

BJMMR

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Section: Resultsmentioning

confidence: 99%

Hemodynamic Treatment Aimed to Reduce Catecholamine Toxicity in Patients Suffering from Septic Shock: An Observational Single Center Study

Hartjes

2013

BJMMR

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“…In adults, dobutamine and milrinone resulted in a similar significant and sustained increase in cardiac index, and both drugs were effective in improving the general hemodynamic variables in postsurgical cardiac patients (6,15).…”

Section: Measurements and Mainmentioning

confidence: 87%

Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone*

Cavigelli-Brunner

Hug

Dave

et al. 2018

Pediatric Critical Care Medicine

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“…The treatment of increased pulmonary vascular resistance has not been fully established due to the lack of selectivity of drugs for pulmonary vasculature. Many agents, such as dobutamine, norepinephrine, levosimendan, nitric oxide and nitroglycerin, were used to relieve pulmonary hypertension during cardiovascular surgery [7][8][9][10]. However, these inotropic drugs have possible systemic or cardiac side effects, like arrhythmia and increased myocardial oxygen consumption resulting in cardiac ischemia and renal failure [11,12].…”

Section: Discussionmentioning

confidence: 99%

Effect of peri-operative milrinone on pulmonary artery pressure in patients undergoing mitral valve replacement

Dolapoglu¹,

Avcı²

2019

Journal of Surgery and Medicine

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How to cite / Atıf için: Dolapoğlu A, Avcı E. Effect of peri-operative milrinone on pulmonary artery pressure in patients undergoing mitral valve replacement.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Increased pulmonary artery pressure is associated with higher surgical risk in patients undergoing mitral valve replacement. The aim of this study was to investigate the effect of milrinone on the pulmonary artery pressures of patients with mitral valve disease (stenosis or regurgitation) who underwent mitral valve replacement surgery. Methods: In this case-control study, 48 patients with mitral valve disease who underwent mitral valve replacement surgery were included. The patients were divided into a control group of 30, who were not administered milrinone, and a study group of 18 who received milrinone perioperatively. Systolic pulmonary artery pressures (SPAP), left ventricle ejection fractions (LVEF) and the following postoperative outcomes were recorded: low cardiac output syndrome, stroke, renal failure, bleeding, ventricular arrhythmia and mortality occurring within 30 days of surgery either in or out of the hospital. Results: In the study group, preoperative LVEFs and postoperative low cardiac output syndrome were lower (72.0 (6.1) vs 62.5(8.4) P<0.001 and P=0.007, respectively), SPAPs were higher (45.50 (7.0) vs 55.06 (5.5), P<0.001), and length of stay in intensive care unit was significantly shorter (4.7 (2.2) vs 3.2 (0.5), P=0.008). Also, reduction in both postoperative SPAP and 30-day SPAP were significantly higher [-11..001, respectively]. Conclusion: We found that using perioperative milrinone reduces the systolic pulmonary artery pressure and lowers the rate of low cardiac output syndrome. Milrinone can be used as an effective therapy to reduce to pulmonary pressure in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Keywords: Mitral valve disease, Pulmonary artery pressure, Mitral valve replacement ÖzAmaç: Pulmoner arter basıncının yüksek olduğu durumlarda mitral kapak değişimi operasyonlarında cerrahi risk yükselmektedir. Bu çalışmada mitral kapak hastalığı nedeniyle cerrahi tedavi uygulanan hastalarda milrinon kullanımının pulmoner basınlar üzerine etkisini araştırmayı amaçladık. Yöntemler: Mitral kapak hastalığı nedeniyle kapak değişimi uygulanan 48 hasta çalışmaya dahil edildi. Hastalar cerahide milrinon kullanımına göre milrinon kullanılan (n=18) ve milrinon kullanılmayan (n=30) olarak ikiye gruba ayrıldı. Cerrahi sonrası 30 günlük süre içinde sistolik pulmoner arter basıncı ve sol ventrikül ejeksiyon fraksiyonları ile birlikte cerrahi sonrası mortalite, düşük kardiyak debi sendromu, inme, böbrek yetmezliği, kanama ve ventrikül aritmileri kaydedildi. Bulgu...

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Comparison of the Effects of Dobutamine and Milrinone on Hemodynamic Parameters and Oxygen Supply in Patients Undergoing Cardiac Surgery with Low Cardiac Output after Anesthetic Induction

Abstract: Both inotropic drugs were similarly effective in restoring tissue blood flow and oxygen supply to adequate levels in patients with low cardiac output undergoing cardiac surgery.

Cited by 12 publications

References 9 publications

Hemodynamic Treatment Aimed to Reduce Catecholamine Toxicity in Patients Suffering from Septic Shock: An Observational Single Center Study

Hemodynamic Treatment Aimed to Reduce Catecholamine Toxicity in Patients Suffering from Septic Shock: An Observational Single Center Study

Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone*

Effect of peri-operative milrinone on pulmonary artery pressure in patients undergoing mitral valve replacement

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