Comparison of the effects of cimetidine and ranitidine in histamine provocation tests in atopic asthma

Abstract

The effects of cimetidine and ranitidine on the bronchial reactivity in the group of 10 patients with atopic bronchial asthma are presented. The patients received 800 mg of cimetidine daily for 6 days and, after a three-day interval, 300 mg of ranitidine daily for a further 6 days. Bronchial reactivity to histamine was determined before the administration of each drug and on the third and sixth days of each course of treatment. A comparison of the effect of cimetidine and ranitidine on the bronchial reactivity of the same patients revealed that after 3 days' exposure to each of the two drugs, cimetidine enhanced bronchial reactivity to a statistically (p less than 0.05) greater extent than ranitidine. Bronchial reactivity was found to increase significantly after 6 days of treatment with each of the drugs but no statistically significant differences were noted on comparing the effect of these drugs. The results seem to indicate that H2 receptor antagonists may cause bronchoconstriction in some patients with bronchial asthma. The blocking effect depends on the type of the drug used and is connected with the chemical structure of the compounds.

Gastroesophageal Reflux and Asthma: Can the Paradox Be Explained?

“…Initially, there were concerns that these medications may cause clinical worsening of asthma because of H2 receptor blockade in the bronchial tree (70)(71)(72). Although some investigators reported that H2 receptor blockers increase bronchial reactivity, their use in asthma appears to be safe (73)(74)(75). A recent critical review identified 12 English-language studies of the effects of medical antireflux therapy in people with asthma with GER (76).…”