Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy

Tanrıverdi, Tuğba Bingöl; Tercan, Mehmet; Halitoğlu, Ayşe Güsun; Kaya, Ahmet; Patmano, Gülçin

doi:10.5152/tjar.2020.30

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Published studies have shown that NLR and PltLR can be considered reliable markers of systemic inflammation [ 21 ]. Studies to date have investigated more types of anesthetic agents, finding that total intravenous anesthesia influences less serum growth of immune mediators than other types of anesthesia [ 22 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

Novac

Boldeanu²,

Rotaru³

et al. 2022

Rom J Morphol Embryol

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Background : The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because the choice of the anesthetic agent can influence the patient’s immune system. Aim : Evaluation of the effect of anesthetic drugs used for total intravenous anesthesia (Propofol and Midazolam) on the inflammatory response after minimally invasive gynecological surgery. Patients, Materials and Methods : The inflammatory response in 20 female patients who underwent minimally invasive gynecological surgery under which intravenous anesthesia was performed. Depending on the combination of anesthetics used, we subdivided the study group into two groups, Group 1 consisting of the patients ( n =10) who were given for total intravenous anesthesia, the combination with Midazolam+Fentanyl, and Group 2 ( n =10) the patients who received the combination of Propofol+Fentanyl, respectively. Surgical interventional procedures included day surgery: diagnostic and operative hysteroscopy, endometrial ablation, surgical treatment of vulvar disorders. Serological profiling of patients was performed by dosing the serum concentration of nucleotide-binding domain (NOD) and leucine-rich repeat protein 3 (NLRP3) inflammasomes, interleukin (IL)-6, tumor necrosis factor-alpha (TNF- α ), IL-10 before and two hours after the surgical procedure. Results : In our study, we found that in both groups of patients (Midazolam+Fentanyl – Group 1, Propofol+Fentanyl – Group 2), NLRP3 and cytokines concentrations in the serum were higher after MIS than those before MIS. Conclusions : It appears that both Midazolam and Fentanyl and Propofol and Fentanyl have an immunomodulatory action due to the anti-inflammatory effect of both anesthetics. Therefore, anesthesiologists must choose an anesthetic method that uses individualized anesthetic agents, depending on the patient’s immune status and disease.

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Section: ⧉ Discussionmentioning

confidence: 99%

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

Novac

Boldeanu²,

Rotaru³

et al. 2022

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

“…In some later studies, the ratios of neutrophil and platelet count to lymphocyte count have been utilized as markers of inflammatory response (platelet-lymphocyte ratio [PLR] and neutrophil-lymphocyte ratio [NLR]). Tanriverdi et al 22 investigated the effect of low-flow anesthesia with desflurane on NLR and PLR in patients undergoing laparoscopic cholecystectomy, and reported that the inflammatory response was diminished meaningfully in the low flow group than in patients administered mid-flow desflurane anesthesia. In another study, Ozcan et al 9 demonstrated via thiol-disulfide hemostasis parameters that the antioxidant properties of sevoflurane were significantly higher compared to desflurane.…”

Section: Discussionmentioning

confidence: 99%

The effect of low flow anesthesia with sevoflurane on oxidative status

Kaşıkara

Özcan

Bıçer

et al. 2022

SMJ

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Objectives: To assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery. Methods:The study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min -1 for anesthesia maintenance after 6 L.min -1 was administered for the first 10 minutes. In the mid-flow anesthesia group, fresh gas flow was applied as 2 L.min -1 . In the high-flow anesthesia group, the fresh gas flow was administered as 4 L.min -1 throughout the operation. Blood samples were obtained before induction, at the 60th minute after induction, and at 2 hours postoperatively. Native thiol, total thiol, disulfide analyzed and disulfide/ native thiol percentage, disulfide/total thiol percentage, and native thiol/total thiol percentage were calculated. Original ArticleResults: Disulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values. Conclusion:It was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect.

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“…Previous studies reported many advantages of LFA. These include a reduced amount of volatile anesthetic agent, improved body temperature, less air pollution, and better protection of pulmonary function [2][3][4]. Therefore, LFA is physiologically more acceptable owing to these advantages.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Low-Flow and Normal-Flow Desflurane Anesthesia on the Frontal QRS-T Angle in Patients Undergoing Rhinoplasty Operation: A Randomized Prospective Study

Tanrıverdi¹,

Tercan²,

Patmano³

et al. 2022

Cureus

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Introduction: Low-flow anesthesia (LFA) has gained more interest worldwide owing to its economic and ecological advantages compared to normal-flow anesthesia (NFA). Desflurane is one of the commonly used anesthetic agents for LFA, but it may prolong myocardial repolarization. Frontal QRS-T angle (f[QRS-T]a) is a novel marker of myocardial repolarization. To our knowledge, no study has compared the effect of LFA and NFA on f(QRS-T)a. In this study, we aimed to compare the effect of the LFA and NFA with desflurane on f(QRS-T)a in patients undergoing rhinoplasty operation.Methods: A total of 80 patients undergoing rhinoplasty operations were included in this prospective study. The patients were randomized into two groups as follows: LFA (n = 40) and NFA (n = 40). The frontal QRS-T angle was calculated from the automatic report of the electrocardiography device (Nihon Kohden, Tokyo, Japan). It was recorded at the following time points: T1: preoperative (basal), T2: immediately after anesthesia induction, T3: immediately after endotracheal intubation, T4: 5 min after endotracheal intubation, T5: 15 min after endotracheal intubation, T6: 30 min after endotracheal intubation, T7: 60 min after endotracheal intubation, T8: end of the operation, T9: 15 min after the end of the operation.Results: Baseline clinical characteristics and laboratory parameters were similar between the two groups. In the LFA group, f(QRS-T)a was significantly increased at only the T3 time point when compared to T1 (P = 0.003). However, in the NFA group, f(QRS-T)a was significantly increased at T3, T4, T5, T6, T7, T8, and T9 time points when compared to the T1 value (P < 0.05, for all). On the other hand, fQRS-Ta was significantly higher in the NFA group than in the LFA group at T4, T5, and T6 time points.Conclusion: In our study, we have shown for the first time that NFA significantly increased the f(QRS-T)a, whereas LFA did not significantly increase the f(QRS-T)a except for immediately after the endotracheal intubation. It was also detected that f(QRS-T)a was significantly higher in the NFA group compared to that in the LFA group. Therefore, it can be concluded that LFA has more protective effects on myocardial repolarization than NFA.

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Comparison of the Effects of Low-flow and Normal-flow Desflurane Anaesthesia on Inflammatory Parameters in Patients Undergoing Laparoscopic Cholecystectomy

Cited by 4 publications

References 21 publications

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

The effect of low flow anesthesia with sevoflurane on oxidative status

The Effect of Low-Flow and Normal-Flow Desflurane Anesthesia on the Frontal QRS-T Angle in Patients Undergoing Rhinoplasty Operation: A Randomized Prospective Study

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