Comparison of the effects of arsenic and cadmium on benzo(a)pyrene-induced micronuclei in mouse bone-marrow

Lewińska, Dobrosława; Arkusz, Joanna; Stańczyk, Małgorzata; Palus, Jadwiga; Dziubałtowska, Elżbieta; Stępnik, Maciej

doi:10.1016/j.mrgentox.2007.04.015

Cited by 27 publications

(19 citation statements)

References 34 publications

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“…According to Patlolla and Tchounwou [48], MN test is more reliable test than CAs or sister chromatid exchange. Previous studies showed that arsenic-induced MN quickly in mice after administration of high doses of arsenic [44,49]. The induction of MN after exposure to As 2 O 3 in our study was found to be dose dependent which is in accordance with the earlier published studies [50,51].…”

Section: Sharma and Gillsupporting

confidence: 93%

“…Similarly, Sharif [43] reported genoprotective and hepatoprotective activities of ginger against carbon tetrachloride toxicity. Various studies made with ginger supplementation revealed that ginger acts as antimutagenic agent against carcinogenic activities in vivo and in vitro studies and is effective in reducing the genotoxic effects and DNA damage [44].…”

Section: Sharma and Gillmentioning

confidence: 99%

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Restorative Effects of Zingiber Officinale on Arsenic-Induced Genotoxic Effects in Chromosomal Structure of Mice

Sharma

Gill

2018

Asian J Pharm Clin Res

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Objective: The present study investigated the antigenotoxic effect of Zingiber officinale (Ginger) on arsenic-induced genotoxic effects in chromosome structure of Swiss albino mice.Methods: Albino mice were divided into four groups: Group I was kept as control, Group II was administrated an oral dose of arsenic trioxide 5 mg/kg bw for 15 days, Group III was given an oral dose of arsenic trioxide 5 mg/kg bw followed by 20 mg/kg bw of ginger orally, and Group IV was administered with 20 mg/kg bw of ginger orally for 15 days and kept as positive control. The autopsies were done from all the groups on 15-day posttreatment, and bone marrow was removed for chromosomal study and for calculating the frequency of micronuclei (MN). Results:It is concluded from this study that long-term arsenic exposure causes chromosomal anomalies, for example, breaks, gaps, rings, stretching, and stickiness which leads to the fragmentation of chromosomes and increases the frequency of MN. Conclusion:The administration of ginger showed modulatory effects against arsenic-induced genotoxicity.

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Section: Sharma and Gillsupporting

confidence: 93%

Section: Sharma and Gillmentioning

confidence: 99%

Restorative Effects of Zingiber Officinale on Arsenic-Induced Genotoxic Effects in Chromosomal Structure of Mice

Sharma

Gill

2018

Asian J Pharm Clin Res

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“…As many people are co-exposed to PAHs and arsenic, it is important to understand their potential mechanism(s) of interaction. Previous studies on the interactions between BaP and As þ3 have shown that As þ3 potentiates BaP toxicity (Lewi nska et al, 2007;Maier et al, 2002). However, these studies were conducted at high concentrations that exceeded those expected to result from environmental exposures.…”

Section: Discussionmentioning

confidence: 99%

Editor’s Highlight: Interactive Genotoxicity Induced by Environmentally Relevant Concentrations of Benzo(a)Pyrene Metabolites and Arsenite in Mouse Thymus Cells

Lauer

Liu

et al. 2016

Toxicol. Sci.

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Arsenic and polycyclic aromatic hydrocarbon (PAH) exposures affect many people worldwide leading to cancer and other diseases. Arsenite (As þ3 ) and certain PAHs are known to cause genotoxicity. However, there is limited information on the interactions between As þ3 and PAHs at environmentally relevant concentrations. The thymus is the primary immune organ for T cell development in mammals. Our previous studies showed that environmentally relevant concentrations of As þ3 induce genotoxicity in mouse thymus cells through Poly(ADP-ribose) polymerase (PARP) inhibition. Certain PAHs, such as the metabolites of benzo(a)pyrene (BaP), are known to cause DNA damage by forming DNA adducts. In the present study, primary mouse thymus cells were examined for DNA damage following 18 hr in vitro treatments with 5 or 50 nM As þ3 and 100 nM BaP, benzo[a]pyrene-7,8-dihydrodiol (BP-Diol), or benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). An interactive increase in genotoxicity and apoptosis were observed following treatments with 5 nM As þ 3 þ 100 nM BP-diol and 50 nM As þ 3 þ 100 nM BPDE. We attribute the increase in DNA damage to inhibition of PARP inhibition leading to decreased DNA repair. To further support this hypothesis, we found that a PARP inhibitor, 3,4-dihydro-5[4-(1-piperindinyl) butoxyl]-1(2H)-isoquinoline (DPQ), also interacted with BP-diol to produce an increase in DNA damage. Interestingly, we also found that As þ3 and BP-diol increased CYP1A1 and CYP1B1 expression, suggesting that increased PAH metabolism may also contribute to genotoxicity. In summary, these results show that the suppression of PARP activity and induction of CYP1A1/ CYP1B1 may act together to increase DNA damage produced by As þ3 and PAHs.

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“…Cette interférence pourrait conduire à l'induction de cancers par altération du processus génétique et du processus de division cellulaire lors de la combinaison avec l'ADN (LEWINSKA et al,2007;LIN et al, 2008 (VERBOST et al, 1989;BJERREGAARD et DEPLEDGE, 1994). De ce fait, certains métaux comme le Cu, le Zn, le Cd, et le Pb peuvent bloquer des perméases impliquées dans les transports ioniques, particulièrement les pompes Na + /K + ATPase .…”

Section: Introductionunclassified

Étude de l’effet du cadmium et du benzo[a]pyrène sur des enzymes de phase I et phase II de biotransformation chez le polychète Nereisdiversicolor

Bouraoui¹,

Ghedira²,

Jebali³

et al. 2009

rseau

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Le présent travail reporte l’effet du cadmium (Cd), du benzo[a]pyrène (B[a]P) ainsi que leur mélange (Cd/B[a]P), à 1 µM, sur les activités d’enzymes impliqués dans la phase I et la phase II de biotransformation chez le polychète Nereis diversicolor en fonction du temps (après 12, 24, 36 et 48 h).L’effet d’une contamination aiguë par du cadmium à une dose de 1 µM après 12, 24 et 36 h montre une inhibition de l’activité NADPH cytochrome C réductase chez les individus contaminés comparés à leurs témoins relatifs, alors que le seul effet du cadmium sur l’activité glutathion-S-transférase n’est enregistré qu’après 36 h d’exposition. Quant au benzo[a]pyrène, les résultats montrent une augmentation significative de l’activité NADPH cytochrome C réductase après 12, 24 et 36 h d’exposition, alors que pour l’activité glutathion-S‑transférase, la variation significative entre les animaux témoins et traités n’est enregistrée qu’à 36 h d’exposition. Le mélange (Cd/B[a]P) inhibe l’activité NADPH cytochrome C réductase chez les individus traités par comparaison aux témoins relatifs et montre un effet inducteur sur l’activité GST sauf après 36 h d’exposition. Ces résultats montrent ainsi les interactions entre les polluants ainsi que leurs effets sur les organismes.The acute effects of cadmium and benzo[a]pyrene, individually and as a mixture, were evaluated on the phase I and phase II biotransformation enzymes of Nereis diversicolor (Polychaeta) collected from unpolluted sites. In the acute assay (1 µM) after 12, 24, 36 and 48 h, the comparison between worms exposed to cadmium and their controls showed an inhibited activity of NADPH cytochrome C reductase after 12, 24 and 36 h. For the activity of glutathione-S-transferase (GST), however, inhibition in the presence of Cd was only noted after 36 h of exposure. Although exposure to benzo[a]pyrene resulted in a significant increase in NADPH cytochrome C reductase activity after 12, 24 and 36 h, a significant difference in glutathione-S-transferase (GST) activity between treated and control animals was only observed after 36 h. The mixture (Cd/B[a]P) seemed to inhibit the activity of NADPH cytochrome C reductase and to induce the activity of GST in individuals but only up until 36 h of exposure. These findings illustrate the interactions between pollutants and their effects on organisms

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Comparison of the effects of arsenic and cadmium on benzo(a)pyrene-induced micronuclei in mouse bone-marrow

Cited by 27 publications

References 34 publications

Restorative Effects of Zingiber Officinale on Arsenic-Induced Genotoxic Effects in Chromosomal Structure of Mice

Restorative Effects of Zingiber Officinale on Arsenic-Induced Genotoxic Effects in Chromosomal Structure of Mice

Editor’s Highlight: Interactive Genotoxicity Induced by Environmentally Relevant Concentrations of Benzo(a)Pyrene Metabolites and Arsenite in Mouse Thymus Cells

Étude de l’effet du cadmium et du benzo[a]pyrène sur des enzymes de phase I et phase II de biotransformation chez le polychète Nereisdiversicolor

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