Comparison of the Effects of Different 19F π Pulses on the Sensitivity and Phaseability of the 19F-13C HSQC

Marchione, Alexander A.; Conklin, Breanna

doi:10.1007/s00723-017-0876-y

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Trade-offs between sensitivity and signal fidelity will determine if SCRAM sequences should be used over traditional hard pulse sequences. Even when hard pulses are not bandwidth limiting, SCRAM sequences may still offer improvement, such as when rf inhomogeneity is substantial. , …”

Section: Resultsmentioning

confidence: 99%

Multipurpose Broadband NMR Inversion Sequences

et al. 2023

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Solution-state 2D correlation experiments increase signal-to-noise, provide improved resolution, and inform about molecular connectivity. NMR experiments are compromised when the nuclei have broad chemical shift ranges that exceed the bandwidth of the experiment. Spectra acquired under these conditions are unphasable and artifact-prone, and peaks may disappear from the spectrum altogether. Existing remedies provide usable spectra only in specific experimental contexts. Here, we introduce a general broadband strategy that leads to a library of high performing NMR experiments. We achieve arbitrary and independent evolution of NMR interactions by only changing delays in our pulse block, letting the block replace inversion elements in any NMR experiment. The experiments improve the experimental bandwidth for both nuclei by an order of magnitude over conventional sequences, covering chemical shift ranges of most molecules, even at ultrahigh field. This library enables robust spectroscopy of molecules such as perfluorinated oils ( 19 F{ 13 C}) and fluorophosphorous compounds in battery electrolytes ( 19 F{ 31 P}).

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Section: Resultsmentioning

confidence: 99%

Multipurpose Broadband NMR Inversion Sequences

et al. 2023

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“… 66,76–78 Nevertheless, even some more recent 19 F experiments yield magnitude mode spectra, 76,78 provide correlation but not the values of coupling constants, 76 or contain refocusing periods that generally decrease their sensitivity. 77,78 Some phase sensitive experiments yield complicated cross peak structures, thereby lowering their sensitivity. 79–81 …”

Section: Resultsmentioning

confidence: 99%

“…The chemical shift correlation experiments involving 19 F have evolved together with general improvements of liquidstate NMR methodology; 75 most notably the use of adiabatic 19 F inversion pulses is now widespread. 66,[76][77][78] Nevertheless, even some more resent 19 F experiments yield magnitude mode spectra, 76,78 provide correlation but not the values of coupling constants, 76 or contain refocusing periods that generally decrease their sensitivity. 77,78 Some phase sensitive experiments yield complicated cross peak structures, thereby lowering their sensitivity.…”

Section: F-centered Experimentsmentioning

confidence: 99%

“…66,[76][77][78] Nevertheless, even some more resent 19 F experiments yield magnitude mode spectra, 76,78 provide correlation but not the values of coupling constants, 76 or contain refocusing periods that generally decrease their sensitivity. 77,78 Some phase sensitive experiments yield complicated cross peak structures, thereby lowering their sensitivity. [79][80][81] The new NMR experiments presented here build on these advances, are phase sensitive and produce cross peaks with a simple pattern that allow identification of active coupling constants.…”

Section: F-centered Experimentsmentioning

confidence: 99%

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New ¹⁹F NMR methodology reveals structures of molecules in complex mixtures of fluorinated compounds

et al. 2022

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“…34,35 The optimal performance of experiments constituting the 19 F-centred NMR approach across a range of 19 F frequencies, is ensured by the use of adiabatic inversion pulses. 36,37 The experiments provide pure phase multiplets with simple structure afforded by 1 H or 19 F decoupling and were designed to minimise the effect of passive spins; they do not use refocusing intervals, which maximises their sensitivity. NMR hardware capable of pulsing simultaneously on 1 H and 19 F frequencies is Fig.…”

Section: Resultsmentioning

confidence: 99%