Comparison of the Effects of Resveratrol and Its Derivatives on the Radiation Response of MCF-7 Breast Cancer Cells

Komorowska, Dominika; Gajewska, Agnieszka; Hikisz, Paweł; Bartosz, Grzegorz; Rodacka, Aleksandra

doi:10.3390/ijms22179511

Cited by 13 publications

(9 citation statements)

References 76 publications

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“…First, the concentration range combined with the time course of PD administration is under-considered when detecting cell viability, apoptosis, and some other indicators. For example, different teams presented different views about how PD affects cell apoptosis with different PD concentrations [13,23]. Here, we showed that although multiple apoptosis results did not yield statistically different comparisons, it was still possible to find that PD was attenuating the apoptosis rate of both cell lines after 24 h but increasing it after 48 h, suggesting that its cytotoxic effects may not be mainly dependent on the apoptotic pathway.…”

Section: Discussionmentioning

confidence: 75%

“…This phenomenon is consistent with another finding when authors compared the effects of resveratrol and its derivatives including PD on the radiation response of breast cancer cells. Though they adopted a different cell line other than lung cancer cells and treated cells with lower concentrations of PD (5 and 25μM), it was shown that, unlike its analogue resveratrol, PD decreased the cell viability without altering apoptosis very much [23]. However, some existing studies showed some non-consistent opinions.…”

Section: Discussionmentioning

confidence: 99%

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Polydatin Radiosensitizes Lung Cancer while Preventing Radiation Injuries by Modulating Tumor-infiltrating B Cells

Wen

Cai²,

Ren³

et al. 2023

Preprint

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Background: Acquired radioresistanceand the undesired normal tissue radiation injuriesseriously discount the therapeutic effect of lung cancer radiotherapy. In this study, we aimed to explore the role and potential mechanism of polydatin in simultaneously decreasing radioresistance and radiation injuries. Methods: The tumor-bearing model of nude mice were used to investigate the tumor inhibition of polydatin on lung cancer and its effect on radiosensitivity, and the effect of polydatin on B cell infiltration in cancerous tissue was investigated. In addition, we performed systemic radiotherapy on BABL/ C mice and evaluated the protective effect of polydatin on radiation injury by the Kaplan-meier survival curve. Moreover, the regulation of polydatin on proliferation and apoptosis of A549 cells was also investigated in vitro. Results: In this study, it is firstly found that polydatin inhibits the growth and promotes the radiosensitivity of lung cancer while reducing the radiation damage of the healthy tissue. Further, it is evidenced that the major mechanism relies on its regulation on body’s immune function, and in particular, the inhibition of radiation-induced B cell infiltration in tumor tissue. Conclusion: These findings show that in addition to tumor inhibition, polydatin also promotes the sensitivity and reduces the adverse reactions of radiotherapy, making itself a promising candidate for boosting lung cancer radiotherapy efficacy.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Polydatin Radiosensitizes Lung Cancer while Preventing Radiation Injuries by Modulating Tumor-infiltrating B Cells

Wen

Cai²,

Ren³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Due to the formation of excessive amounts of ROS characteristic of tumorigenic processes, most cancer cells show increased overexpression of SOD . Furthermore, there are many studies reporting that RES and its derivatives, as well as fatty acids themselves, cause increased ROS accumulation in cancer cells [ 15 , 24 , 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Studies on the Anticancer and Antioxidant Activities of Resveratrol and Long-Chain Fatty Acid Esters

Szczepańska

Rychlicka

Groborz

et al. 2023

IJMS

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Resveratrol (RES) is gaining recognition as a natural bioactive compound. To expand the possible applications of RES with its enhanced bioactivity as well as to increase the health benefits of long-chain fatty acids, a lipophilization process of RES was performed using three fatty acids: palmitic acid (PA), oleic acid (OA), and conjugated linoleic acid (CLA). The obtained mono-, di-, and tri-esters of RES were evaluated for their anticancer and antioxidant properties against lung carcinoma (A549), colorectal adenocarcinoma (HT29), and pancreatic ductal adenocarcinoma (BxPC3) cell lines. Human fibroblast (BJ) cells were used as a control. Several parameters were investigated: cell viability and apoptosis, including the expression of major pro- and anti-apoptotic markers, as well as the expression of superoxide dismutase, a key enzyme of the body’s antioxidant barrier. Three of the obtained esters: mono-RES-OA, mono-RES-CLA, and tri-RES-PA, which significantly reduced the tumor cell viability up to 23%, at concentrations 25, 10, 50 μg/mL, respectively, turned out to be particularly interesting. The above-mentioned resveratrol derivatives similarly increased the tumor cells’ apoptosis by modifying their caspase activity of pro-apoptotic pathways (p21, p53, and Bax). Moreover, among the mentioned esters, mono-RES-OA induced apoptosis of the analyzed cell lines most strongly, reducing the number of viable cells up to 48% for HT29 cells versus 36% for pure RES. Furthermore, the selected esters exhibited antioxidant properties towards the normal BJ cell line by regulating the expression of major pro-antioxidant genes (superoxide dismutases—SOD1 and SOD2) without the effect on their expression in the tumor, and therefore reducing the defense of cancer cells against increased oxidative stress induced by high ROS accumulation. The obtained results indicate that the esters of RES and long-chain fatty acids allow enhancement of their biological activity. The RES derivatives have the potential for being applied in cancer prevention and treatment, as well as for oxidative stress suppression.

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“…This phenomenon is consistent with another finding when authors compared the effects of resveratrol and its derivatives including PD on the radiation response of breast cancer cells. Though they adopted a different cell line other than lung cancer cells and treated cells with lower concentrations of PD (5 and 25 μM), it was shown that, unlike its analog resveratrol, PD decreased the cell viability without altering apoptosis very much (Komorowska et al 2021 ). However, some existing studies showed some non-consistent opinions.…”

Section: Discussionmentioning

confidence: 99%

Polydatin radiosensitizes lung cancer while preventing radiation injuries by modulating tumor-infiltrating B cells

Wen

Cai²,

Ren³

et al. 2023

J Cancer Res Clin Oncol

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Background Acquired radio-resistance and the undesired normal tissue radiation injuries seriously discount the therapeutic effect of lung cancer radiotherapy. In this study, we aimed to explore the role and potential mechanism of polydatin in simultaneously decreasing radioresistance and radiation injuries. Methods The tumor-bearing model of nude mice was used to investigate the tumor inhibition of polydatin on lung cancer and its effect on radiosensitivity, and the effect of polydatin on B cell infiltration in cancerous tissue was investigated. In addition, we performed systemic radiotherapy on BABL/C mice and evaluated the protective effect of polydatin on radiation injury by the Kaplan–Meier survival curve. Moreover, the regulation of polydatin on proliferation and apoptosis of A549 cells was also investigated in vitro. Results In this study, it is first found that polydatin inhibits the growth and promotes the radiosensitivity of lung cancer while reducing the radiation damage of the healthy tissue. Further, it is evidenced that the major mechanism relies on its regulation on body’s immune function, and in particular, the inhibition of radiation-induced B cell infiltration in tumor tissue. Conclusion These findings show that in addition to tumor inhibition, polydatin also promotes the sensitivity and reduces the adverse reactions of radiotherapy, making itself a promising candidate for boosting lung cancer radiotherapy efficacy.

show abstract

Comparison of the Effects of Resveratrol and Its Derivatives on the Radiation Response of MCF-7 Breast Cancer Cells

Cited by 13 publications

References 76 publications

Polydatin Radiosensitizes Lung Cancer while Preventing Radiation Injuries by Modulating Tumor-infiltrating B Cells

Polydatin Radiosensitizes Lung Cancer while Preventing Radiation Injuries by Modulating Tumor-infiltrating B Cells

Studies on the Anticancer and Antioxidant Activities of Resveratrol and Long-Chain Fatty Acid Esters

Polydatin radiosensitizes lung cancer while preventing radiation injuries by modulating tumor-infiltrating B cells

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