Comparison of the Effects of Propofol and Midazolam Sedation on Post-dural Puncture Headache

Abstract

Background: Post-dural puncture headache (PDPH) is a common side effect after spinal anesthesia. Objectives: This study aimed to compare the sedative dose of propofol and midazolam in reducing headaches after spinal anesthesia. Methods: In order to conduct this study, 80 candidates for spinal anesthesia were divided into two groups, A and B. Both groups received spinal anesthesia with marcaine. In group A, propofol was infused slowly at a dose of 30 µg per minute, and in group B, 1 mg midazolam was injected intravenously. In the two groups, the incidence and intensity of headaches were measured using the VAS pain scale. Data were analyzed using Mann-Whitney and t-tests at a significance level of 0.05. Results: In this study, 65% (52) were male and 35% (28) were female. There was no significant difference between the two groups in terms of demographic information (P > 0.05). In the propofol group, the incidence and severity of headaches were significantly lower than in the midazolam group (P < 0.01). Conclusions: This study's results indicated that administering low-dose propofol as a sedative during spinal anesthesia may be more effective in reducing PDPH than midazolam.