Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three‐way crossover study

Abstract

BackgroundThe effectiveness of proton pump inhibitors is influenced by meals and administration time.

25 Years of Proton Pump Inhibitors: A Comprehensive Review

“…This increase in half-life correspondingly increases the area under the plasma concentration curve (AUC) by over 20-fold, representing increased tissue exposure and thus duration of effect at the parietal cell cannaliculus 97–99. While definitive trials of clinical efficacy are still unavailable, this revision to the structure of PPIs has intriguing future potential.…”

The effect of time‐of‐day dosing on the pharmacokinetics and pharmacodynamics of dexlansoprazole MR: evidence for dosing flexibility with a Dual Delayed Release proton pump inhibitor

“…24 In this study, AUC and C max values were significantly higher after morning dosing, but pH control was superior after the fasting evening dose. The present study is the first report of the pharmacokinetics and pharmacodynamics of a PPI administered at four different times of day: before a standard breakfast, lunch, dinner or evening snack that approximates meals typical for each respective time of day.…”

The effect of once daily omeprazole and succinic acid (VECAM) vs once daily omeprazole on 24‐h intragastric pH

“…Due to the meal‐substituting effect of SA, and the perceived benefit for patient compliance VECAM was dosed at bedtime. Comparisons of different dosing regimens was conducted as in other studies 10 …”