Comparison of the effects of pentoxifylline, simvastatin, tamoxifen, and losartan on cavernous bodies after penile fracture in rats: a stereological study

Eslahi, Ali; Shirazi, Mehdi; Khoshnood, Omid; Noorafshan, Ali; Karbalay‐Doust, Saied

doi:10.1038/s41443-019-0175-2

Cited by 4 publications

(10 citation statements)

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“…The mixture was vortexed, and the absorbance of the mixture was measured spectrophotometrically at 412 nm. [ 20 ]…”

Section: Methodsmentioning

confidence: 99%

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: This study assessed the histopathological and oxidative effects of topical Aloe Vera (AV) on penile fractures (PF) formed experimentally in a rat model. METHODS: Forty Wistar albino rats (220-250 g) were used. The PF model was created experimentally with a number 15 lancet. Then, the rats were randomly and equally divided into five groups. In the first group (C), no incision was formed. In the second group (P), an incision was formed. In the third group (PR), the incision line was closed primarily. In the fourth group (PA), AV was locally applied onto the incision without suturing for three days. In the last group (PRA), AV was applied to the primary repair region for three days. All groups were compared to each other according to histopathological and biochemical data. RESULTS: Hyperemia-bleeding was observed to be suppressed in the PRA group compared to the other groups (p<0.001). Inflammation was observed only in Groups PR and PRA (p<0.001). Significant fibrosis was observed in the PA and PRA groups compared to the other groups (p<0.001). Superoxide Dismutase (SOD) and Glutathione (GSH) values increased in favor of Group PRA (p=0.009 and p=0.035, respectively). Total Oxidative Status (TOS) and Malondialdehyde (MDA) values decreased in favor of Group PA (p=0.036 and p=0.026, respectively). Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1 beta (IL-1ß) levels decreased mostly in the PRA group, but these changes did not reach statistical significance (p>0.05). CONCLUSION: Topical AV application reduces tissue inflammation and oxidative stress but appears to increase the development of fibrosis after PF.

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“…The mixture was vortexed, and the absorbance of the mixture was measured spectrophotometrically at 412 nm. [ 20 ]…”

Section: Methodsmentioning

confidence: 99%

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Girgin

2024

Ulus Travma Acil Cerrahi Derg

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“…It has been shown to reduce the production of tumour necrosis factor (TNF), downregulate TGF-β, suppress the production of platelet-activating factors, and inhibit the action of platelet-activating factor on neutrophils ( 28 ). Eslahi et al ( 29 ) demonstrated how PTX diminished the formation of collagen bundles and the number of fibroblasts. PTX has also been demonstrated to reduce blood viscosity thus improving circulation; this increase in microcirculation may also play a role in the prevention or management of fibrosis ( 30 ).…”

Section: Preoperative Evaluation and Considerationsmentioning

confidence: 99%

Penile fibrosis—still scarring urologists today: a narrative review

Fernandez Crespo,

Stroie,

Taylor

et al. 2024

Transl Androl Urol

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Background and Objective Implantation of penile prosthesis (PP) into scarred and fibrotic corpora can be a difficult challenge. In this review article, we provide a review of penile fibrosis, discuss current medical and surgical management and summarize preventative strategies. Methods In this study, we searched PubMed between the years 2000–2023 for publications with search strategy: “penile fibrosis” OR “scarred corpora” OR “fibrosed corpora”. Key Content and Findings This search returned a total of 137 articles. We examine the evidence for preoperative patient evaluation and penile ultrasound (US), oral phosphodiesterase-5 inhibitors, pentoxifylline, and L-arginine, vacuum device therapy and the use of surgical approaches and tools in the context of complex penile fibrosis cases. Severe penile fibrosis is most associated with priapism and infection. Estimating the degree of fibrosis via preoperative US may help set realistic patient expectations. Phosphodiesterase inhibitors and L-arginine reduce fibrosis in animal models however their impact in humans remains unclear despite theoretical advantage for their use. Vacuum device therapy may preserve penile length following priapism and infected PP cases. The use of Coloplast Narrow-Based or AMS-700 CXR implants are used primarily for severe fibrosis. Various surgical excisional/incisional techniques, the Carrion-Rossello, Mooreville Uramix cavernotomes and reverse cutting scissors are all options, and their use varies from case to case. Finally, prevention of penile fibrosis in patients with history of penile implant infection and the safety of early implantation of a penile implant in patients with refractory priapism is encouraged. Conclusions The management of penile fibrosis remains a challenge but there are multiple options to assist clinicians. Complex cases should be managed and studied at high volume centers.

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“…The volume density "Vv" of collagen bundles, smooth muscle cells, cavernous sinuses, and vessels was calculated by the "point-counting method" and the following formula 19 [Figure 4 a]:…”

Section: Estimation Of the Volume Density Of The Collagen Bundles Smo...mentioning

confidence: 99%

“…The total number of fibroblasts or myocytes was estimated by multiplying the numerical density by V(cavernous bodies) [Figure 4 b]. 19 Fibroblasts were recognized by their specific criteria (having plentiful and irregularly branched cytoplasms, a large ovoid euchromatic nucleus, and a prominent nucleolus). Smooth muscle cells were also recognized by their spindle shape and single central nucleus.…”

Section: Estimation Of the Numerical Density Of The Fibroblasts And S...mentioning

confidence: 99%

Penile Girth Enhancement using Amniotic Membrane in a Rabbit Model

Ariafar

Karbalay‐Doust

Ahmed

et al. 2022

Sultan Qaboos Univ Med J

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Objectives: This study aimed to evaluate the efficacy of Penile Girth Enhancement (PGE) using Amniotic Membrane (AM) as a graft in a rabbit model. Additionally, stereological studies were used to obtain quantitative histological data regarding the structure of the penis. Methods: In this study, 20 adult male rabbits of similar age and weight were allocated to two sham and surgery+AM groups. Both groups underwent surgery by longitudinal Ishape midline incision of the tunica albuginea on the dorsal surface of the penis. The surgery +AM group underwent PGE by AM graft. The penile length and mid circumference were measured using a Vernier caliper before and two months after the surgery. Stereological studies were used to obtain quantitative histological data regarding the structure of the penis. Results: The mean total volume and diameter of the penis increased in the surgery +AM group (p<0.03 and p<0.04, respectively). The stereological evaluation showed a significant increase in the mean volumes of the tunica albuginea and corpora cavernosa in the surgery +AM group compared to the sham group (p<0.01, p< 0.03). Additionally, the mean volume density of the collagen bundles, muscle fibers, and cavernous sinuses and the total number of fibroblasts and smooth muscle cells increased in the surgery +AM group compared to the sham group (p<0.01, p<0.01, p<0.03, p<0.01, and p<0.05, respectively). No infections, bleedings, or other complications were seen. Conclusions: AM is a method that has appeared promising for material use in penile enhancement. Thus, it may be used for PGE in the future. Keywords: Amniotic Membrane; Histopathology; Animal; Penile Girth Enhancement.

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Comparison of the effects of pentoxifylline, simvastatin, tamoxifen, and losartan on cavernous bodies after penile fracture in rats: a stereological study

Cited by 4 publications

References 47 publications

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

The effects of topical aloe vera on an experimentally designed penile fracture model in rats

Penile fibrosis—still scarring urologists today: a narrative review

Penile Girth Enhancement using Amniotic Membrane in a Rabbit Model

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