Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: A 30-day, randomized, double-masked, artificial tear substitute-controlled trial

Avunduk, Avni Murat; Tekelioğlu, Yavuz; Türk, Adem; Akyol, Nurettin

doi:10.1016/j.clinthera.2005.09.013

Cited by 43 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased levels of inflammatory adhesion molecules and the presence of cells on the ocular surface are not findings specific to pterygium; these have also been demonstrated in several other ocular conditions such as chronic allergic eye disease, vernal keratoconjunctivitis, scleritis, corneal disease and ocular rosaceous keratoconjunctivitis sicca [35,36,37,38,39,40]. …”

Section: Discussionmentioning

confidence: 99%

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

Tekelioğlu¹,

Türk

Avunduk

et al. 2006

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Background/Aim: Pterygium is a relatively frequent ocular surface disease with an unexplained etiopathogenesis. Our study was carried out with the aim to identify the presence of inflammatory cells and mediators such as T-lymphocyte subgroups (CD4 and CD8), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and human leukocyte antigen-DR (HLA-DR) in pterygium tissue. Methods: Pterygium tissue, obtained from 24 patients, and normal conjunctival tissue, from the nasal bulbar conjunctiva obtained from 14 patients operated for ocular perforations or vitrectomy, were separated into epithelial and stromal components under the microscope and suspended with phosphate-buffered saline solution to form a suspension. Cell suspensions were treated with specific antibodies for ICAM-1, VCAM-1, and HLA-DR and T-lymphocyte subgroups and evaluated with flow cytometry. The obtained data were compared statistically. Results: When compared to the control tissue samples, higher rates of ICAM-1-positive cells, VCAM-1-positive cells and HLA-DR-positive cells were recorded in pterygium tissue samples. CD4 and CD8 lymphocytes were also found to be at higher levels when compared to the control group. There was a statistically significant difference between the two groups. Conclusion: When compared with normal conjunctival tissue, pterygium tissue had increased levels of T-lymphocyte infiltration and inflammatory markers demonstrating the possible contribution of cellular immunity to the pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

Tekelioğlu¹,

Türk

Avunduk

et al. 2006

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alternative objective measurements on biomarkers may be obtained through conjunctival impression cytology. Samples from impression cytology processed by flow cytometry determine percentage of cells expressing ICAM-1, VCAM-1, human leukocyte antigen-DR and b1-integrin (CD29) [44 ].…”

Section: Methods To Simulate and Measure Outcomesmentioning

confidence: 99%

Pharmacology of ocular allergy

Schultz

2006

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Important pharmacologic properties of targets have been revealed. First, histamine is more specifically antagonized by second generation antihistamines. Second, newly formed mediators and downstream responders (prostaglandins, leukotrienes, interleukins, intercellular adhesion molecule 1, tumor necrosis factor, vascular cell adhesion molecule, eosinophils and neutrophils) are more selectively antagonized by dual/multiple-action agents.

show abstract

“…Olopatadine 0.1% (Patanol) also demonstrated a clinically significant reduction in hyperemia in an environmental study [38]. Both ketotifen and olopatadine were shown to diminish the expression of cell adhesion molecules and inflammatory markers on conjunctival surface cells in patients with seasonal AC [39].…”

Section: Dual-acting Antihistamine/mast Cell-stabilizing Moleculesmentioning

confidence: 94%

Antihistamines in Ocular Allergy: Are They All Created Equal?

Abelson

McLaughlin

Gomes

2011

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Use of topical antihistamines in the treatment of allergic conjunctivitis has evolved over the past several decades as our knowledge of the nature of the underlying disease has progressed. Formulations for the eye typically employ H(1)-receptor antagonists with a dual action, both directly as competitors for histamine receptor occupancy and as mast cell-stabilizing agents. Many of these compounds also display activity against late-phase allergic symptoms. Of the newest available drugs, several have a prolonged duration of action allowing once-daily dosing. Future development is likely to focus on long-acting agents such as these and on drugs that can target additional histamine receptor subtypes.

show abstract

Comparison of the effects of ketotifen fumarate 0.025% and olopatadine HCl 0.1% ophthalmic solutions in seasonal allergic conjunctivities: A 30-day, randomized, double-masked, artificial tear substitute-controlled trial

Cited by 43 publications

References 21 publications

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

Flow Cytometrical Analysis of Adhesion Molecules, T-Lymphocyte Subpopulations and Inflammatory Markers in Pterygium

Pharmacology of ocular allergy

Antihistamines in Ocular Allergy: Are They All Created Equal?

Contact Info

Product

Resources

About