Comparison of the effects of remifentanil and remifentanil plus lidocaine on intubation conditions in intellectually disabled patients

Abstract

Acceptable intubation parameters were achieved in 24 patients in Group 1 (96%) and in 23 patients in Group 2 (92%). In intra-group comparisons, the heart rate and mean arterial pressure values at all-time points in both groups showed a significant decrease compared to baseline values (p=0.000) CONCLUSION: By the addition of 2 μg/kg remifentanil during sevoflurane induction, successful tracheal intubation can be accomplished without using muscle relaxants in intellectually disabled patients who undergo outpatient dental extraction. Also worth noting, the addition of 1mg/kg lidocaine to 2 μg/kg remifentanil does not provide any additional improvement in the intubation parameters.

Myasthenia gravis – can i relax my patient? a case report

“…We chose remifentanil due to its short half-life and absence of neuromuscular effects, as well as its ability to facilitate tracheal intubation without muscle relaxants. 2 Although we are aware of the remifentanil's central respiratory depression effect, its context sensitive half-life of 9.5 minutes significantly lowers these risk, with a fast plasmatic elimination. Although there are reports of the use of TIVA or inhaled anaesthetics combined with opioids without neuromuscular agents, 3 we decided to include a neuromuscular blocker in our approach to maximize intubation and surgery conditions, considering our patient's absence of respiratory symptoms and low risk of postoperative exacerbations.…”

The Effect of Remifentanil on Intubation Conditions in Patients Undergoing Caesarean Delivery Under General Anesthesia: Comparison of Two Dosing Regimens

“…This finding did not come as a surprise, because it is known that remifentanil, used with propofol or thiopentone to facilitate endotracheal intubation, is an acceptable alternative to neuromuscular blocking drugs, since it may potentiate depression of the laryngeal reflexes [24]. Remifentanil boluses of 24 µg/kg (depending on a study) with propofol 2 mg/kg or thiopentone 5 mg/kg, provided satisfactory or excellent intubating conditions [2528].…”