Comparison of the effects of adenosine, isoproterenol and their combinations on pulmonary transit time in rats using contrast echocardiography

Shi, Yun-Yan; Wang, Bo; Zheng, Xiao‐Zhi

doi:10.11152/mu-3088

Cited by 5 publications

(10 citation statements)

References 14 publications

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“…All patients were required to have undergone transthoracic echocardiography within 2 hours of computed tomographic angiographic diagnosis of PE. Exclusion criteria were: the use of chemotherapy and vasoactive drugs [6], hepatopulmonary syndrome, pulmonary arteriovenous fistula and standard echo images of inadequate quality.…”

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Pulmonary transit time (PTT) is the time for a sample of blood to pass through the pulmonary circulation [3][4][5][6]. It depends on PBV and cardiac output (CO) according to the formula PTT = PBV/CO [3][4][5][6]. Here, the PTT refers to the nPTT (normalized PTT; the PTT divided by the mean R-R interval of electrocardiogram and CO refers to the right ventricular stroke volume (SV RV ).…”

Section: Introductionmentioning

confidence: 99%

“…Here, the PTT refers to the nPTT (normalized PTT; the PTT divided by the mean R-R interval of electrocardiogram and CO refers to the right ventricular stroke volume (SV RV ). Previous studies have demonstrated PTT can be measured using real time contrast echocardiography of low mechanical index, such as myocardial contrast echocardiography, with high accuracy and reproducibility [6][7][8]. Meanwhile, CO can also be measured by conventional echocardiography.…”

Section: Introductionmentioning

confidence: 99%

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Differential diagnosis of acute pulmonary embolism using contrast echocardiography

2022

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Aims: Acute pulmonary embolism (aPE) leads to a significant decrease in antegrade pulmonary blood volume (PBV), which can be measured by contrast echocardiography at the bedside. The aim of this work was to evaluate the feasibility and performance of PBV differentiating between patients with and without aPE.Material and methods: A total of 89 patients underwent computed tomography pulmonary angiography (CTPA) for suspected aPE were enrolled in the study. Their clinical and conventional echocardiographic characteristics were collected. Contrast echocardiography with measurements of PBV were performed.Results: There were 57 patients with aPE, with a mean Mastora pulmonary artery obstruction index (PAOI) of 56.14%. Pulmonary transit time (PTT), normalized PTT (nPTT) and PBV in patients with aPE was less than one half of those in patients without PE (p<0.05). There was significant negative correlation between PBV and Mastora PAOI (r=-0.897, p<0.01). None of the conventional echocardiographic parameters had an area under the receiver operating characteristic curve of >0.5, while it was 0.997(0.984~1.010) for PBV in differentiating between patients with aPE or not. The optimal cutoff valueof PBV was 370ml, with a sensitivity of 100%, a specificity of 95.45% and an accuracy of 96.55%.Conclusions: PBV had a powerful performance in differentiating between patients with aPE or not, and a PBV of <370ml indicated aPE. Contrast echocardiography is enormously useful in the recognition and differentiation of PE and can assess the severity of the PE and the patient’s response to therapy.

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Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential diagnosis of acute pulmonary embolism using contrast echocardiography

2022

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“…Pulmonary transit time (PTT), defined as the time it takes for contrast agents to travel from the right ventricle (RV) to the left atrium (LA), has been taken as a metric for integrative evaluation of cardiopulmonary function (Ait Ali et al, 2019; Brittain et al, 2015; Colin et al, 2020; Herold et al, 2016a; de Lepper et al, 2017; Su et al, 2022). In recent years, PPT has been proved to be a useful parameter for the diagnosis of hepatopulmonary syndrome (Zhao et al, 2018) and the evaluation of arterial oxygenation in patients with chronic liver disease with early hepatopulmonary syndrome (Katsuta et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary transit time has close relation with pulmonary pulse wave transit time in normal subjects

Zhang

Zheng

2022

Clin Physio Funct Imaging

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Background: Pulmonary transit time (PTT) and pulmonary pulse wave transit time (pPTT) are useful parameters for the evaluation of cardiopulmonary circulation and vascular alterations, but their relationship remains unknown. The aim of this study was to investigate the correlation between PTT and pPTT.Methods: A total of 60 healthy volunteers were involved in this study. They were divided into two groups (30 participants per group): <50 years and >50 years. They all underwent Doppler echocardiography of pulmonary vein flow and contrast echocardiography with the measurement of pPTT and PTT, respectively. The correlation between PTT and pPTT was deduced.Results: Compared with Group of <50 years, there was a significant increment in left atrial volume index, left atrial pressure and pulmonary artery stiffness but a significant reduction in acceleration times of pulmonary artery flow in Group of >50 years (p < 0.05). Group >50 years had longer PTT and but reduced normalized PTT by R-R interval (NPTT), reduced normalized pPTT by R-R interval (NpPTT) than Group <50 years (p < 0.05), while there was no significant difference in pPTT between the two groups (p > 0.05). PTT and NPTT were all negatively correlated with pPTT and NpPTT. The statistically significant strongest correlation was observed between PTT and NpPTT (r = −0.886, p < 0.0001). The regression equation for them was y = 7.4396-13.095x (R 2 = 0.785; p < 0.001), where x and y represent NpPTT and PTT, respectively. Conclusion:PTT had close relation with pPTT in normal subjects. From the regression equation for them, we can get the value of PTT simply and easily by noninvasively measured pPTT.

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Saline bolus for negative contrast perfusion imaging in magnetic particle imaging

Mohn,

Exner,

Szwargulski

et al. 2023

Phys. Med. Biol.

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Objective. Magnetic particle imaging (MPI) is capable of high temporal resolution measurements of the spatial distribution of magnetic nanoparticles and therefore well suited for perfusion imaging, which is an important tool in medical diagnosis. Perfusion imaging in MPI usually requires a fresh bolus of tracer material to capture the key signal dynamics. Here, we propose a method to decouple the imaging sequence from the injection of additional tracer material, without further increasing the administered iron dose in the body with each image. Approach. A bolus of physiological saline solution without any particles (negative contrast) diminishes the steady-state concentration of a long-circulating tracer during passage. This depression in the measured concentration contributes to the required contrast dynamics. The presence of a long-circulating tracer is therefore a prerequisite to obtain the negative contrast. As a quantitative tracer based imaging method, the signal is linear in the tracer concentration for any location that contains nanoparticles and zero in the surrounding tissue which does not provide any intrinsic signal. After tracer injection, the concentration over time (positive contrast) can be utilized to calculate dynamic diagnostic parameters like perfusion parameters in vessels and organs. Every acquired perfusion image thus requires a new bolus of tracer with a sufficiently large iron dose to be visible above the background. Main results. Perfusion parameters are calculated based on the time response of the proposed negative bolus and compared to a positive bolus. Results from phantom experiments show that normalized signals from positive and negative boli are concurrent and deviations of calculated perfusion maps are low. Significance. Our method opens up the possibility to increase the total monitoring time of a future patient by utilizing a positive-negative contrast sequence, while minimizing the iron dose per acquired image.

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Comparison of the effects of adenosine, isoproterenol and their combinations on pulmonary transit time in rats using contrast echocardiography

Cited by 5 publications

References 14 publications

Differential diagnosis of acute pulmonary embolism using contrast echocardiography

Differential diagnosis of acute pulmonary embolism using contrast echocardiography

Pulmonary transit time has close relation with pulmonary pulse wave transit time in normal subjects

Saline bolus for negative contrast perfusion imaging in magnetic particle imaging

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