Comparison of the effects of isoprenaline, orciprenaline, salbutamol and isoetharine on the cardiovascular system of anaesthetized dogs

Abstract

Summary1. The intravenous injection of isoprenaline, orciprenaline, salbutamol and isoetharine increased heart rate in anaesthetized dogs. Log dose-response curves obtained with a series of doses of salbutamol and isoetharine were flatter than those for isoprenaline and orciprenaline. The order of activity of the drugs in increasing heart rate was isoprenaline, orciprenaline, and salbutamol = isoetharine.2. The injection into the external iliac artery of isoprenaline, orciprenaline, salbutamol and isoetharine produced dose dependent increases in femoral blood flow. Log dose-response curves for all drugs were parallel. The order of activity of the drugs was isoprenaline, salbutamol=isoetharine and orciprenaline. 3. Salbutamol and isoetharine were less active than orciprenaline in increasing heart rate but more active in increasing femoral blood flow. 4. These observations indicate that salbutamol and isoetharine have a greater effect on P2 than on 13-adrenoceptors in the cardiovascular system.

Metabolic and Cardiovascular Effects of Isoprenaline and Salbutamol in the Dog

“…Although the two log-dose response curves were of different shapes, the upper parts of each were parallel and over these dose ranges isoprenaline was 30 times more active than salbutamol. In previous studies by Ekue et al (1971) in anaesthetized dogs, isoprenaline was 200 times more active than salbutamol in increasing heart rate, but in this study full dose-response curves were not examined and the drugs were administered as single intravenous doses instead of by infusion. Neither study attempted to assess the influence of reflex vagal effects produced by the drugs.…”

“…Salbutamol, a drug which has a greater effect on 12-than on 01 -adrenoceptors, has been studied by Cullum, Farmer, Jack & Levy (1969) and by Ekue, Shanks & Zaidi (1971). These workers showed that in dogs, salbutamol had approximately one-eighth the potency of isoprenaline in producing increases in femoral blood flow (a 132-adrenoceptor response) but had only one-two hundredth the potency of isoprenaline in increasing heart rate (a ,B -adrenoceptor response) but no study of the metabolic effects of this compound in the dog has been reported.…”

THE ROLE OF β1 ‐ AND β2‐ADRENOCEPTORS IN THE INHIBITION OF GASTRIC ACID SECRETION IN THE DOG

“…Using the latter approach we have sought to characterize the P-adrenoceptors that mediate inhibition of gastric secretion by studying the non-selective ,B-adrenoceptor agonist isoprenaline (Ekue, Shanks & Zaidi, 1971), the #2-selective agonist salbutamol (Cullum, Farmer, Jack & Levy, 1969) and their interactions with the /3l-and #2-adrenoceptor antagonist propranolol (Shanks, 1966), the fil-selective antagonist practolol (Dunlop & Shanks, 1968) and the f2-selective antagonist H35/25 (Levy, 1967). (+)-Propranolol, the inactive isomer of propranolol, was used as a control for effects unrelated to ,B-adrenoceptor blockade (Howe & Shanks, 1966).…”

Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation

“…Salbutamol (Fig. 7) is an effective drug used to treat conditions such as primary bronchial asthma [57] and cardiovascular disease [58], etc. Salbutamol was docked into the MD equilibrium structures of WT and mutated β2AR, respectively.…”