Comparison of the effects of escitalopram and nortriptyline on painful symptoms in patients with major depression

Jaracz, Jan; Gattner, Karolina; Moczko, Jerzy; Hauser, Joanna

doi:10.1016/j.genhosppsych.2014.10.005

Cited by 17 publications

(12 citation statements)

References 35 publications

(35 reference statements)

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“…Individuals with fibromyalgia, have an imbalance of pain fibers and norepinephrine‐sensitive sympathetic innervation . In an interesting study of pain in those suffering from depression, Jaracz et al . found selective noradrenergic (and serotonergic) antidepressants to mediate the physical pain symptoms of depression, and found efficacy for dual‐action drugs in the treatment of depression and pain.…”

Section: Autonomic Modulation Of Painmentioning

confidence: 99%

“…26 Individuals with fibromyalgia, have an imbalance of pain fibers and norepinephrine-sensitive sympathetic innervation. 26 In an interesting study of pain in those suffering from depression, Jaracz et al 27 found selective noradrenergic (and serotonergic) antidepressants to mediate the physical pain symptoms of depression, and found efficacy for dual-action drugs in the treatment of depression and pain. While the role of noradrenergic pain modulation in the action of opioids is debated, 28 noradrenergic pain modulation has been shown to be involved in descending pain modulatory circuits, including the rostral ventromedial medulla (RVM) and periaqueductal gray (PAG).…”

Section: Noradrenergic Modulation Of Painmentioning

confidence: 99%

See 1 more Smart Citation

Therapeutic Basis of Clinical Pain Modulation

Kirkpatrick

McEntire

Hambsch

et al. 2015

Clinical Translational Sci

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Pain is a hallmark of almost all bodily ailments and can be modulated by agents, including analgesics and anesthetics that suppress pain signals in the central nervous system. Defects in the modulatory systems, including the endogenous pain-inhibitory pathways, are a major factor in the initiation and chronicity of pain. Thus, pain modulation is particularly applicable to the practice of medicine. This review summarizes the existing literature on pain modulation. Here, we critically reviewed the literature from PubMed on pain modulation published primarily within last 5 years in high impact journals. Specifically, we have discussed important anatomical landmarks of pain modulation and outlined the endogenous networks and underlying mechanisms of clinically relevant pain modulatory methods. The Gate Control Theory is briefly presented with discussion on the capacity of pain modulation to cause both hyper- and hypoalgesia. An emphasis has been given to highlight key areas in pain research that, because of unanswered questions or therapeutic potential, merit additional scientific scrutiny. The information presented in this article would be helpful in developing novel therapies, metrics, and interventions for improved patient management.

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Section: Autonomic Modulation Of Painmentioning

confidence: 99%

Section: Noradrenergic Modulation Of Painmentioning

confidence: 99%

Therapeutic Basis of Clinical Pain Modulation

Kirkpatrick

McEntire

Hambsch

et al. 2015

Clinical Translational Sci

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show abstract

“…It has pain-relieving effects in painful diabetic neuropathy and somatoform disorders [54,55]. For the treatment of pain symptoms associated with depression, escitalopram is equally effective with nortriptyline [56].…”

Section: Escitaloprammentioning

confidence: 99%

Serotonin Reuptake Inhibitors and Their Role in Chronic Pain Management

Onuţu¹,

Dîrzu²,

Petrișor³

2019

Serotonin

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Serotonin has a particular place in the modulation of pain. Experimental studies have described 5-HT1-7 receptors and their effects on facilitation or inhibition of nociceptive input. Selective serotonin reuptake inhibitors (SSRIs) and serotoninnorepinephrine reuptake inhibitors showed efficient and safer than tricyclic antidepressants in neuropathic pain. Although there is evidence regarding the beneficial impact of SSRIs in the multimodal acute pain management, studies are still searching for the potentially favorable effect of these drugs in the prevention of chronic postoperative pain. The scope of this chapter would be to update the knowledge regarding serotonin involving in pain pathways and to highlight the importance and contribution of serotonin reuptake inhibitors in the multimodal pain management schemes.

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“…In addition to the potential of opioid analgesia, they also cause a reduction in muscle tone and anxiolytics [60,[62][63][64]. However, studies by Jaracz et al [65] indicate the similar efficacy of SNRI and SSRI in relieving unexplained painful physical symptoms associated with depression. In patients with severe depression, comparable analgesic efficacy has been demonstrated for venlafaxine, escitalopram, and nortriptyline [66].…”

Section: Treatment Of Depressionmentioning

confidence: 99%

Coexistence of Chronic Pain and Depression: A Short Review with a Focus on the Antidepressant Effect of Tramadol and Buprenorphine

Szkutnik-Fiedler¹,

Grześkowiak²

2018

Neuropsychiatry

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It is known that there is a strong relationship between chronic pain and depression, and both of these diseases can intensify each other. In addition to mental illnesses, there are also a number of somatic symptoms, including pain. While pain, especially chronic, is always associated with mental suffering, which can aggravate the symptoms of depression. Proper and timely identification of coexistence of these conditions allows for effective and safe pharmacotherapy.This article reviews the literature on the coexistence of chronic pain and depressive disorders. The common mechanisms of both these diseases and the frequency of their coexistence have been described. The results of studies on the problem of treatment of patients with chronic pain with concomitant depression and patients with depression declaring pain are presented. The role of tramadol and buprenorphine in relieving symptoms of depression, including severe and refractory to traditional treatment, has also been described.

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Comparison of the effects of escitalopram and nortriptyline on painful symptoms in patients with major depression

Cited by 17 publications

References 35 publications

Therapeutic Basis of Clinical Pain Modulation

Therapeutic Basis of Clinical Pain Modulation

Serotonin Reuptake Inhibitors and Their Role in Chronic Pain Management

Coexistence of Chronic Pain and Depression: A Short Review with a Focus on the Antidepressant Effect of Tramadol and Buprenorphine

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