Comparison of the effects of a 7-day period of non-compliance on blood pressure control using three different antihypertensive agents

Bg, Girvin; Gd, Johnston

doi:10.1097/01.hjh.0000125440.28861.d6

Cited by 23 publications

(12 citation statements)

References 17 publications

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“…The process of identifying studies eligible for inclusion in our review is summarized in the Figure. We retrieved and screened 440 citations and abstracts from our searches of all relevant sources, 34 of which were judged to merit examination of the full article. Seventeen of the latter met all predefined inclusion criteria 6–23 . We excluded six of these studies for one of the following reasons: medication adherence was not assessed, 9,20,21 incomplete data on adherence outcome, 21 HBPM was not used as the intervention, 12,17 or they were not RCTs 10 .…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen of the latter met all predefined inclusion criteria 6–23 . We excluded six of these studies for one of the following reasons: medication adherence was not assessed, 9,20,21 incomplete data on adherence outcome, 21 HBPM was not used as the intervention, 12,17 or they were not RCTs 10 . Thus, only 11 RCTs were included in this systematic review 6,8,11,13–16,18,19,22,23 …”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

Ogedegbe

Schoenthaler

2006

J of Clinical Hypertension

161

118

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Home blood pressure monitoring (HBPM) improves blood pressure control, but little is known about its effects on medication adherence. The authors conducted a systematic review of the published literature on the effects of HBPM on medication adherence. Of 440 abstracts and citations reviewed, 11 randomized control trials met predefined criteria. Six of the 11 randomized controlled trials reported statistically significant improvement in medication adherence; 84% of these were complex interventions involving the use of HBPM in combination with other adherence-enhancing strategies such as patient counseling by nurses, pharmacists, or a telephone-linked system; patient education; and the use of timed medication reminders. Interventions conducted in primary care settings were not effective compared with those that occurred in hospital-based clinics or nonclinical settings. The data on the effects of HBPM on patients' medication-taking behavior are mixed. Future studies should investigate the independent effects of HBPM in primary care practices where the majority of hypertensive patients receive their care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

Ogedegbe

Schoenthaler

2006

J of Clinical Hypertension

161

118

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“…Patients taking an antihypertensive drug will need to stop it for 2 weeks prior to the study to be confirmed for eligibility, to allow time for most of the effects of the blood pressure drug to vanish [32]. …”

Section: Methodsmentioning

confidence: 99%

The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trial

Cichelero

Martinez

Fuchs

et al. 2014

Trials

152

138

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BackgroundObstructive sleep apnea (OSA) and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases.Methods/DesignThis is a randomized double-blind clinical trial, comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than 40 years of age with stage I hypertension (140 to 159/90 to 99 mmHg) and moderate OSA (15 to 30 apneas/hour of sleep). The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring. The secondary outcomes are adverse events, somnolence scale (Epworth), ventilatory parameters and C reactive protein levels. The follow-up will last 8 weeks. There will be 29 participants per group. The project has been approved by the ethics committee of our institution.DiscussionThe role of fluid retention in OSA has been known for several decades. The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea. As well as testing the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment.Trial registrationClinicalTrials.gov: NCT01896661

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“…Overall, Ca V ␤ 2 in the heart serves as a positive regulator of I Ca,L (11). We recently showed (13,19) (22,32,38); however, little is known about the long-term cardiac effects of these drugs on cardiac myocytes. The primary objective of this study was to test the hypothesis that cardiac I Ca,L is homeostatically regulated.…”

mentioning

confidence: 99%

“…Thus both positive and negative regulators, in the form of auxiliary proteins, influence ultimate I Ca,L density. Ca 2ϩ channel blockers (CCBs) are frequently used to regulate blood pressure in hypertensive patients (22,32,38); however, little is known about the long-term cardiac effects of these drugs on cardiac myocytes. The primary objective of this study was to test the hypothesis that cardiac I Ca,L is homeostatically regulated.…”

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confidence: 99%

Chronic verapamil treatment remodelsI_Ca,Lin mouse ventricle

Schroder

Magyar

Burgess

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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(41), although in late-stage heart failure the consensus finding is that I Ca,L declines (47). The unchanged level of I Ca,L in all but late-stage heart failure suggests that ventricular myocytes may have the capacity to homeostatically regulate I Ca,L .At the plasma membrane the Ca 2ϩ channel complex exists as a heteromultimer consisting of the ␣ 1 -subunit (Ca V 1.2), a cytosolic ␤-subunit (Ca V ␤ 2 ), and a covalently linked ␣ 2 ␦-subunit. Ca V 1.2, the pore-forming subunit, determines ion selectivity and voltage sensitivity and is a binding site for clinically used Ca 2ϩ channel blockers. Ca V ␤ coexpression primarily increases Ca V 1.2 current density in heterologous expression systems (4,8,21,48) and in myocytes that overexpress Ca V ␤ (45). In addition to increasing functional expression, Ca V ␤s alter channel kinetics (29,36,44) and voltage dependence (5, 28, 39). Among the accessory subunits, the Ca V ␤s are the only accessory proteins known to increase current density. In contrast to Ca V ␤, the ␣ 2 ␦-subunit has modest effects on channel current density and has variable effects on channel voltage dependence and kinetics (6,25,26,31). Overall, Ca V ␤ 2 in the heart serves as a positive regulator of I Ca,L (11). We recently showed (13,19) channel function. Thus both positive and negative regulators, in the form of auxiliary proteins, influence ultimate I Ca,L density. Ca 2ϩ channel blockers (CCBs) are frequently used to regulate blood pressure in hypertensive patients (22,32,38); however, little is known about the long-term cardiac effects of these drugs on cardiac myocytes. The primary objective of this study was to test the hypothesis that cardiac I Ca,L is homeostatically regulated. We postulated that Ca 2ϩ entering through the L-type channel provides feedback regulation. According to our hypothesis, decreasing I Ca,L , such as via chronic CCB, would elicit upregulation of I Ca,L . Conversely, stressors that acutely increase cytosolic Ca 2ϩ cause long-term decreases of I Ca,L as in heart failure (7, 46). Our results demonstrate that long-term Ca 2ϩ channel blockade induces an increase of Ca V 1.2 mRNA and protein and significantly increases basal I Ca,L . In contrast, chronic ␤-adrenergic stimulation induces upregulation of positive and negative regulators of I Ca,L with no significant change in basal I Ca,L . Together, these results suggest that the main pore-forming subunit plays a greater role in determining I Ca,L than auxiliary subunits. MATERIALS AND METHODSMini-osmotic pumps. Female or male ICR mice (12-14 wk of age) weighing between 25 and 30 g were anesthetized with a ketaminexylazine mixture (ip), allowing the subcutaneous implantation of mini-osmotic pumps (Alzet, model 2001). The pumps were filled with verapamil (Ver), isoproterenol (Iso), isoproterenol and verapamil (Iso ϩ Ver), or vehicle alone (0.02% ascorbic acid). Mice carrying drug-loaded minipumps are abbreviated as Iso, Ver, and Iso ϩ Ver for pumps containing isoproterenol, verapamil, or the two drugs together. Control animals c...

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Comparison of the effects of a 7-day period of non-compliance on blood pressure control using three different antihypertensive agents

Abstract: Bendroflumethiazide maintained blood pressure control during a period of drug omission better than nifedipine or enalapril.

Cited by 23 publications

References 17 publications

A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trial

Chronic verapamil treatment remodelsI_Ca,Lin mouse ventricle

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Comparison of the effects of a 7-day period of non-compliance on blood pressure control using three different antihypertensive agents

Abstract: Bendroflumethiazide maintained blood pressure control during a period of drug omission better than nifedipine or enalapril.

Cited by 23 publications

References 17 publications

A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

A Systematic Review of the Effects of Home Blood Pressure Monitoring on Medication Adherence

The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trial

Chronic verapamil treatment remodelsICa,Lin mouse ventricle

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Product

Resources

About

Chronic verapamil treatment remodelsI_Ca,Lin mouse ventricle