Comparison of the effects of peripherally administered kisspeptins

Mikkelsen, Jens D.; Bentsen, Agnete H.; Ansel, Laura; Simonneaux, Valérie; Juul, Anders

doi:10.1016/j.regpep.2008.10.001

Cited by 67 publications

(52 citation statements)

References 38 publications

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“…Accordingly, KP release into the monkey median eminence was found to be pulsatile, with secretory peaks that coincide with the LH pulses [64]. Furthermore, the proposed axonal site of action for KP is in accordance with the observation that the peripheral injection of KP results in rapid increases of LH release [23,35,36,65] which can be prevented with the GnRH antagonist acylin [65]. KP is likely to influence GnRH neurons outside the blood-brain barrier because it does not induce c-fos expression in GnRH cell nuclei of the preoptic area.…”

Section: Discussionmentioning

confidence: 74%

Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women

et al. 2014

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Neuronal populations that synthesize kisspeptin (KP), neurokinin B (NKB) and substance P (SP) in the hypothalamic infundibular nucleus of humans are partly overlapping. These cells are important upstream regulators of gonadotropin-releasing hormone (GnRH) neurosecretion. Homologous neurons in laboratory animals are thought to modulate episodic GnRH secretion primarily via influencing KP receptors on the hypophysiotropic fiber projections of GnRH neurons. To explore the structural basis of this putative axo-axonal communication in humans, we analyzed the anatomical relationship of KP-immunoreactive (IR), NKB-IR and SP-IR axon plexuses with hypophysiotropic GnRH fiber projections. Immunohistochemical studies were carried out on histological samples from postmenopausal women. The neuropeptide-IR axons innervated densely the portal capillary network in the postinfundibular eminence. Subsets of the fibers formed descending tracts in the infundibular stalk, some reaching the neurohypophysis. KP-IR, NKB-IR and SP-IR plexuses intermingled, and established occasional contacts, with hypophysiotropic GnRH fibers in the postinfundibular eminence and through their lengthy course while descending within the infundibular stalk. Triple-immunofluorescent studies also revealed considerable overlap between the KP, NKB and SP signals in individual fibers, providing evidence that these peptidergic projections arise from neurons of the mediobasal hypothalamus. These neuroanatomical observations indicate that the hypophysiotropic projections of human GnRH neurons in the postinfundibular eminence and the descending GnRH tract coursing through the infundibular stalk to the neurohypophysis are exposed to neurotransmitters/neuropeptides released by dense KP-IR, NKB-IR and SP-IR fiber plexuses. Localization and characterization of axonal neuropeptide receptors will be required to clarify the putative autocrine and paracrine interactions in these anatomical regions.

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Section: Discussionmentioning

confidence: 74%

Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women

et al. 2014

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“…Interestingly, kisspeptin levels showed a strong positive correlation with FAI in obese patients with PCOS. The effect of kisspeptin on free testosterone levels has been previously documented in adult mice, and peripheral administration of kisspeptin analogues was found to strongly increase serum testosterone levels when given systemically [27]. Also, a recent study by Brown et al [28] showed that in the hypothalamus of dihydrotestosterone-treated rodents, kiss1 mRNA and levels of kisspeptin immunoreactivity were significantly reduced.…”

Section: Discussionmentioning

confidence: 98%

Kisspeptin, Leptin, and Retinol-Binding Protein 4 in Women with Polycystic Ovary Syndrome

Jeon

Lee

Jung

et al. 2013

Gynecol Obstet Invest

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Objectives: To compare plasma kisspeptin, serum leptin, and serum retinol-binding protein 4 (RBP4) levels in women with and without polycystic ovary syndrome (PCOS) and to correlate these among each other and with clinical, hormonal, and metabolic parameters. Methods: Ninety women, including 54 women with PCOS and 36 without PCOS, participated in this study. For all patients, history and physical examinations were performed and blood samples were collected between days 3 and 8 of a spontaneous bleeding episode in the PCOS group and during normal menses of controls. Plasma kisspeptin, serum leptin, and serum RBP4 levels were measured using specific commercial assays. Results: Kisspeptin, leptin, and RBP4 levels were significantly higher in the PCOS group than in controls. Kisspeptin and RBP4 levels were significantly higher among obese PCOS patients than controls. Leptin levels were higher among obese PCOS patients than non-obese PCOS patients or controls. Kisspeptin and leptin levels of PCOS patients were significantly correlated with RBP4 levels. When only obese PCOS patients were analyzed, kisspeptin levels correlated with only the free androgen index. Conclusions: These findings suggest that kisspeptin, leptin, and RBP4 are associated with metabolic disturbances in women with PCOS.

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“…Shorter isoforms of kisspeptin, consisting of the 10-, 13-, and 14-amino acid amidated C-terminal sequences, also possess biological activity and have been shown to have potency similar to that of the longer form in vitro (Mead et al, 2007b;Mikkelsen et al, 2009), although a discrepant report exists (Pheng et al, 2009). The shorter isoforms have been reported to have a lower potency in vivo than KP-54 (Thompson et al, 2009), possibly as a result of increased susceptibility to degradation in the circulation.…”

Section: A Naturally Occurring Agonistsmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function

Kirby

Maguire²,

Colledge³

et al. 2010

Pharmacol Rev

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Comparison of the effects of peripherally administered kisspeptins

Cited by 67 publications

References 38 publications

Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women

Hypophysiotropic Gonadotropin-Releasing Hormone Projections Are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women

Kisspeptin, Leptin, and Retinol-Binding Protein 4 in Women with Polycystic Ovary Syndrome

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function

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