Comparison of the Effectiveness of Metoclopramide, Ondansetron, and Granisetron on the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy

Öksüz, Hafize; Zencirci, Beyazit; Ezberci, Meral

doi:10.1089/lap.2006.0243

Cited by 17 publications

(11 citation statements)

References 27 publications

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“…No statistically significant effects were observed (OR 1.92, 95 % CI 0.30–12.21). Twenty-five studies were excluded from this analysis because they reported zero events in both arms [38, 41, 44, 55, 56, 58, 62, 67, 70, 72, 77, 78, 80, 107, 109, 115, 120, 126, 128, 130, 131, 134, 149, 157, 158]. …”

Section: Resultsmentioning

confidence: 99%

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Tricco

Soobiah

Blondal

et al. 2015

BMC Med

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BackgroundSerotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients, but these agents may be harmful. We conducted a systematic review on the comparative safety of 5-HT3 receptor antagonists.MethodsSearches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.ResultsOverall, 120 studies and 27,787 patients were included after screening of 7,608 citations and 1,014 full-text articles. Significantly more patients receiving granisetron plus dexamethasone experienced an arrhythmia relative to placebo (odds ratio (OR) 2.96, 95 % confidence interval (CI) 1.11–7.94), ondansetron (OR 3.23, 95 % CI 1.17–8.95), dolasetron (OR 4.37, 95 % CI 1.51–12.62), tropisetron (OR 3.27, 95 % CI 1.02–10.43), and ondansetron plus dexamethasone (OR 5.75, 95 % CI 1.71–19.34) in a NMA including 31 randomized clinical trials (RCTs) and 6,623 patients of all ages. No statistically significant differences in delirium frequency were observed across all treatment comparisons in a NMA including 18 RCTs and 3,652 patients.ConclusionGranisetron plus dexamethasone increases the risk of arrhythmia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-015-0379-3) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Tricco

Soobiah

Blondal

et al. 2015

BMC Med

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“…22 Another study suggested that granisetron is more effective than inhalation isopropyl alcohol in preventing postoperative nausea and vomiting ( PONV ) following laparoscopic procedures, yet no significant difference was found between granisetron prophylaxis and no prophylaxis at all. 23 Other studies have shown granisetron to be more effective than other drugs in preventing PONV post laparoscopy, 24 especially when combined with steroid agents. 25,26 Subjects received doses ranging from 35.3 mg/kg to 77.5 mg/kg, and only when given in doses greater than 45 mg/kg was the drug more effective than the placebo, with its efficacy increasing proportionately with dosage.…”

Section: Discussionmentioning

confidence: 99%

Does Granisetron Eliminate the Gag Reflex? A Crossover, Double-Blind, Placebo-Controlled Pilot Study

Barenboim

Dvoyris

Kaufman

2009

Anesthesia Progress

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Although gagging is a frequent problem that, when severe, can jeopardize the dental procedure, no single protocol is used to alleviate this phenomenon. Selective 5-HT 3 antagonists, such as granisetron, may attenuate gagging. In this study, granisetron and placebo were administered intravenously, in a crossover, doubleblind manner, to 25 healthy volunteers in 2 different sessions. Gagging levels were recorded before and after administration, as were BP, pulse, and O 2 saturation. Recorded results were analyzed with the use of tests for nonparametric values (P 5 .05). A significant increase in the depth of swab insertion was noted after administration of both placebo and drug. The increase in drug effectiveness correlated with decreased body weight. The true efficacy of granisetron in gagger patients with this treatment protocol has yet to be fully established, although it has been theorized that an increased dosage of granisetron may have a better effect.

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“…Previously, anti-cholinergics, anti-histamines and phenothiazines were used to prevent PONV (8); but low effect of these medications and their complications led to drug shifts. Recent studies have shown that serotonin receptor antagonists are more effective than previous medications in PONV prophylaxis (3,9). It has been proved that Granisetron and Ondansetron are effective medications in this field (9) but by considering the high price of these drugs, suitable substitutes are required.…”

Section: Introductionmentioning

confidence: 99%

Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy

Hessami

Yari²

2012

anesthpain

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Dexamethasone is a low price corticosteroid which has anti-inflammatory effects. This article help us to find a cost effective drug for prophylaxis of PONV.Background: Post-operative nausea and vomiting (PONV) is one of the common problems after laparoscopic cholecystectomy. Objectives: The current study aimed to compare Dexamethasone effect with that of Granisetron in prevention of PONV. Patients and Methods: In the current study 104 patients aged 20-60 with ASA class I or II who were candidates for laparoscopic cholecystectomy were included in the study. Patients were randomly divided into two groups of A and B. 15 minutes before anesthesia induction, in group a patient's 3 mg Granisetron and in group B patients 8 mg Dexamethasone was intravenously injected. Then both groups underwent general anesthesia with similar medications. After operation the prevalence of nausea and vomiting was assessed at three time intervals (0-6 hours, 6-12 hours and 12-24 hours after consciousness). SPSS software version 16 was employed to analyze data. T test, chi-square test and Fischer exact test were performed level of significance was P < 0.05. Results: There was no significant difference between age, gender proportion, weight, height, and body mass index (BMI) of patients in the two groups. In Dexamethasone group, seven patients experienced nausea and three patients had vomiting, and in Granisetron group, five patients experienced nausea and three patients had vomiting after consciousness. Statistical analysis indicated no significant difference between the two groups in this regard. Conclusions: Intravenous injection of 8 mg Dexamethasone or 3 mg Granisetron before anesthesia induction had similar effects in prophylaxis of nausea and vomiting after laparoscopic cholecystectomy.

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Comparison of the Effectiveness of Metoclopramide, Ondansetron, and Granisetron on the Prevention of Nausea and Vomiting After Laparoscopic Cholecystectomy

Abstract: Granisetron, when given prophylactically, resulted in a significantly lower incidence of PONV than metoclopramide and ondansetron, whereas metoclopramide was ineffective. Garnisetron may be an effective treatment in the proflaxy of PONV.

Cited by 17 publications

References 27 publications

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Does Granisetron Eliminate the Gag Reflex? A Crossover, Double-Blind, Placebo-Controlled Pilot Study

Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy

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