Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen

Zerrouk, Naïma; Mennini, Natascia; Maestrelli, Francesca; Chemtob, C; Mura, Paola

doi:10.1016/s0939-6411(03)00112-7

Cited by 63 publications

(44 citation statements)

References 20 publications

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“…Thus, more contact may be allowed resulting in an interaction that could not occur in their solid PMs and was not seen in their FTIR results. The possibilty of conversion of some crystalline compounds into highly dispersed state due to the thermal energy supplied during DSC scan has been reported in other studies (5,32). Excess Tris without interaction during DSC scan may account for the presence of the two peaks (141°C Fig.…”

Section: Characterization Of the Prepared Solid Binary Systemssupporting

confidence: 55%

Improvement of Dissolution and Hypoglycemic Efficacy of Glimepiride by Different Carriers

et al. 2012

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Abstract. Effects of tromethamine (Tris), polyvinylpyrrolidone (PVP-K25), and low molecular weight chitosan (LM-CH) on dissolution and therapeutic efficacy of glimepiride (Gmp) were investigated using physical mixtures (PMs), coground mixtures, coprecipitates (Coppts) or kneaded mixtures (KMs), and compared with drug alone. Fourier transform infrared spectroscopy, differential scanning colorimetry, and X-ray diffractometry were performed to identify any physicochemical interaction with Gmp. Surface morphology was examined via scanning electron microscopy. The results of Gmp in vitro dissolution revealed that it was greatly enhanced by Coppt with Tris or PVP-K25 and KM with LM-CH at a drug to carrier ratio of 1:8. Gmp amorphization by PVP-K25 and LM-CH was a major factor in increasing Gmp dissolution. Being basic, Tris might increase the pH of the microdiffusion layer around Gmp particles improving its dissolution. Formation of water-soluble complexes suggested by solubility study may also explain the enhanced dissolution. Capsules were prepared from Coppts and KM 1:8 drug to carrier binary systems and also with Tris PMs. In vivo, the hypoglycemic efficacy of Gmp capsules in rabbits increased by 1.63-, 1.50-, and 1.46-fold for 1:8 Coppts with Tris or PVP-K25 and KM with LM-CH respectively, compared with Gmp alone. Surprisingly, the response to Tris PM 1:20 capsules was 1.52-fold revealing statistically insignificant difference to that of Tris Coppt 1:8 (1.63 fold). As a conclusion, dissolution enhancement and hypoglycemic potentiation by 1:20 PM of Gmp/Tris, being simple and easy to prepare, may enable development of a reduced-dose and fast-release oral dosage form of Gmp.

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Section: Characterization Of the Prepared Solid Binary Systemssupporting

confidence: 55%

Improvement of Dissolution and Hypoglycemic Efficacy of Glimepiride by Different Carriers

et al. 2012

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“…The results are in accordance with analgesic eŠects of poorly water soluble NSAID in PM and SD. 6,12) Figure 1 illustrates the anti-in‰ammatory eŠect of MLX, PM and SD. Both PM and SD showed signiˆcant increase in anti-in‰ammatory eŠect, in the carrageenan induced paw oedema, as compared to MLX at 3 and 5 h after carrageenan injection.…”

Section: Resultsmentioning

confidence: 99%

Investigations on Analgesic, Anti-inflammatory and Ulcerogenic Potential of Meloxicam Solid Dispersion Prepared with Skimmed Milk

Mishra

Kumar

2006

YAKUGAKU ZASSHI

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Meloxicam, a non-steroidal anti-in‰ammatory drug is used in the treatment of rheumatoid arthritis and osteoarthritis. It is practically insoluble in water leading to poor dissolution, variations in bioavailability and gastric irritation on oral administration. In order to modulate its gastric side eŠect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were prepared with skimmed milk. The analgesic, anti-in‰ammatory and ulcerogenic eŠects were assessed for physical mixture and solid dispersion in comparison to pure meloxicam. The results indicate that solid dispersion possess better analgesic and anti-in‰ammatory properties with less ulcerogenic potential as compared to pure meloxicam.

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“…Esta formulação permitiu a redução da dose requerida para obter o efeito analgésico, com uma consequente redução da incidência de efeitos adversos. 127 …”

Section: Quitosana Como Analgésicounclassified

Quitosana: biopolímero funcional com potencial industrial biomédico

Laranjeira¹,

Fávere²

2009

Quím. Nova

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Recebido em 27/1/09; aceito em 13/3/09; publicado na web em 2/4/09 CHITOSAN: FUNCTIONAL BYOPOLYMER WITH BIOMEDICAL INDUSTRIAL POTENTIAL. The importance of chitosan has grown significantly over the last two decades due to its renewable and biodegradable source, and also because of the recent increase in the knowledge of its functionality in the technological and biomedical applications. The present article reviews the biopolymer chitosan and its derivatives as versatile biomaterials for potential drug delivery systems, as well as tissue engineering applications, analgesia and treatment of arthritis.

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Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen

Cited by 63 publications

References 20 publications

Improvement of Dissolution and Hypoglycemic Efficacy of Glimepiride by Different Carriers

Improvement of Dissolution and Hypoglycemic Efficacy of Glimepiride by Different Carriers

Investigations on Analgesic, Anti-inflammatory and Ulcerogenic Potential of Meloxicam Solid Dispersion Prepared with Skimmed Milk

Quitosana: biopolímero funcional com potencial industrial biomédico

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