Comparison of the effect of glyphosate and glyphosate-based herbicide on hippocampal neurogenesis after developmental exposure in rats

Similar toxicity potential of glyphosate and glyphosate‐based herbicide on cerebellar development after maternal exposure in rats

“…Given that the cell permeability of GBHs containing surfactants might be higher than that of GlyP alone, 59,60 the surfactants contained in GBH products might have participated in the enhanced neurotoxicity of GlyP in this study, as observed in our previous study on the effects of GlyP and GBH targeting hippocampal neurogenesis. 8 It should be noted that our results do not exact clarify the potential of GlyP to affect human health since the doses of GlyP in the present study were extremely high compared with the exposure levels of GlyP reported in humans. 61…”

“…The animal experiment was identical to that previously reported. 8 Briefly, mated female rats were assigned randomly to four groups of 12 animals in each group; animals in the three groups received either GlyP at doses of 1.5 or 3.0% in the diet or 1.0% GBH (corresponding to 0.36% GlyP) dissolved in deionized water as drinking water from GD 6 to day 21 postpartum (Figure 1). The duration of administration was determined according to the OECD guideline for the testing of developmental neurotoxicity (Test no.…”

“…We recently reported that maternal exposure to GlyP and GBH in rats, according to the exposure regimen defined by the Organization for Economic Co‐operation and Development (OECD) guideline for the testing of developmental neurotoxicity (Test no. 426), 7 might similarly disrupt neurogenesis accompanied by compensatory responses attributable to facilitation of synaptic plasticity and elevation of oxidative stress in the hippocampus through adulthood 8 …”

“…426), 7 might similarly disrupt neurogenesis accompanied by compensatory responses attributable to facilitation of synaptic plasticity and elevation of oxidative stress in the hippocampus through adulthood. 8 Although the role of the cerebellum in controlling movement is well known, this structure also plays a role in higher brain functions, such as cognitive function, and cerebellar disorders might extend beyond ataxias to include autism spectrum disorders and schizophrenia as developmental disorders. 9 The adult cerebellar cortex is composed of three layers: the granular layer (GL), Purkinje cell layer, and molecular layer (ML).…”

Exposição ao glifosato e alterações neurológicas - uma revisão bibliográfica

“…Estudos em matrizes gravídicas de ratos com exposição através de água potável com uma contaminação de 3% de glifosato, durante o início da gestão perpassando até os primeiros dias 15 dias de vida, exercem uma influência negativa e deletéria hipocampo e peptídeos; moléculas de aminoácidos que exercem função de desenvolvimento e sobrevivência dos neurônios [24][25][26] . Alterações no hipocampo são sugestivos de alterações no processo de novas memórias e também estão associadas ao aprendizado e às emoções, essas alterações no processo de aprendizagem interfere diretamente na aprendizagem motora em todas as fases, fase de aquisição, retenção e transferência, assim sendo é notável que a exposição perinatal cause alterações significativas no tecido neural, e que poderão repercutir de forma negativa e danosa no processo de formação neural 17,27,28 .…”