Comparison of the Effect of Local and Systemic Injection of Resveratrol on Cutaneous Wound Healing in Rats

Bilgiç, Tayfun

doi:10.1177/1534734620938168

Cited by 8 publications

(8 citation statements)

References 27 publications

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“…The sample size was calculated based on the single mean formula [n = (z r/D)2]. In this study, n was considered as the number of sample subjects', z (constant) = 1.96 for 95% confidence, r (standard deviation) = 0.4mm, 10 and D (precision) = 0.2 unit. The resulting number was adjusted, and the final sample size in each group = n + (n_0.2).…”

Section: Methodsmentioning

confidence: 99%

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Naser¹,

Hamed²,

Taqa³

2022

J Oral Res

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Background: Numerous types of cancer are of substantial medical and social concern, posing a major challenge to modern medicine. Chemotherapeutic drugs include the use of nucleosides, which are composed of nucleic acid and sugar. Objective: This study aims to assess the impact of systemic chemotherapeutic drugs at a therapeutic dose on the wound healing process of the oral mucosa. Material and Methods: 30 healthy rats were randomly divided into two main groups based on the study material, 15 rats in each group. Group A (control) was given a single dose of normal saline (1ml/kg, intraperitoneal), and Group B (study) a single injection of gemcitabine (50 mg /Kg, intraperitoneal). After anesthesia, a full-thickness soft tissue incision (0.5 cm length) on the right side of the buccal mucosa was made in the animals of both groups. Each group was subdivided according to the time of sacrifice into 3, 7, 14 days after surgery, at the end of the experimental periods, specimens were collected for histopathological study, and samples of blood were obtained from retro-orbital venous plexus and collected in microfuge tubes and levels of antioxidant enzymes were measured by ELISA. The data were analyzed statistically at a 0.05 level of significance. Results: Gemcitabine delayed the onset of wound cascade (inflammation and re-epithelization) which lead to worsening healing of the oral tissue; it also resulted in a decrease of the antioxidant activity of glutathione peroxidase and catalase, as well as activated caspase 3, which induces cell apoptosis. Conclusion: Gemcitabine showed negative feedback on oral tissue wound healing through delayed wound healing cascade and by inducing apoptosis.

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Section: Methodsmentioning

confidence: 99%

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Naser¹,

Hamed²,

Taqa³

2022

J Oral Res

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“…Both systemic and local administrations importantly boosted wound healing and enhanced the tensile strength of the epidermis. Local subcutaneous injection of RSV emerged as a better therapeutic approach than systemic treatment due to the neovascularization to help wound healing [220]. On the other hand, topical administration of 5% RSV ointment was demonstrated to stimulate burn wound healing by enhancing the progress of wound contraction via collagen fiber synthesis, granulation tissue creation, and epithelial regeneration in rats [221].…”

Section: Wound Healing Propertiesmentioning

confidence: 99%

Resveratrol: A Review on the Biological Activity and Applications

Bejenaru,

Biţă,

Belu

et al. 2024

Applied Sciences

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Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.

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“…Angiogenesis also plays a central role in wound healing, and resveratrol is discussed to influence neovascularisation 62 . Among the known growth factors, vascular endothelial growth factor (VEGF) is believed to be one of the most prevalent, effective, and long‐term signal‐stimulating angiogenesis in wounds 49 .…”

Section: Resveratrol In Skin Wound Healingmentioning

confidence: 99%

The impact of resveratrol on skin wound healing, scarring, and aging

Hecker

Schellnegger

Hofmann

et al. 2021

International Wound Journal

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Resveratrol is a well‐known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti‐inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring, and (photo‐)aging of the skin. Hence, this review highlighted the most relevant studies involving resveratrol in wound healing, scarring, and photo‐aging of the skin. A systematic review was performed and the database PubMed was searched for suitable publications. Only original articles in English that investigated the effects of resveratrol in wound healing, scarring, and (photo‐)aging of the skin were analysed. The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo‐aging of the skin. Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol‐associated effects, more evidence based in vitro and in vivo studies are needed.

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Comparison of the Effect of Local and Systemic Injection of Resveratrol on Cutaneous Wound Healing in Rats

Cited by 8 publications

References 27 publications

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Resveratrol: A Review on the Biological Activity and Applications

The impact of resveratrol on skin wound healing, scarring, and aging

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