Comparison of the effect of citalopram, bupropion, sertraline, and tricyclic antidepressants on QTc: A cross-sectional study

Straley, Craig M.; Sochacki, Marisa; Reed, Ellen D.; Carr, Chelsea N.; Baugh, Terrence Bradley

doi:10.1016/j.jad.2021.08.149

Cited by 2 publications

(5 citation statements)

References 38 publications

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“…In the current study, there were at least two causes of markedly prolonged QTc interval in the patient, one of which may be citalopram. Citalopram is a depression drug with a high cardiac safety profile (Straley et al, 2021 ). Therefore, it is widely used for the treatment of depression (Straley et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

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Torsade de pointes caused by citalopram during the pacemaker battery‐depletion phase: A case report

Wang

Sun

Tao

2022

Noninvasive Electrocardiol

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Pacemaker battery depletion is a gradual process that is usually divided into two stages: elective replacement indication and end of life (Bian et al., 2020). To prolong administration of working hours during the first stage, modifications to the procedures of pacemaker are required (Bian et al., 2020;Crépeau-Gendron et al., 2019). The first phase can last many months, providing a perfect opportunity to replace the pacemaker and epicardial leads (Crépeau-Gendron et al., 2019). If the pacemaker is not replaced on time, it gradually stops working, resulting in lethal adverse and nonfatal complications (Crépeau-Gendron et al., 2019;Drew et al., 2010). Citalopram, a selective serotonin reuptake inhibitor, is now critical in the treatment of several psychiatric disorders (Lasocka et al., 2021). Citalopram causes a delayed lengthening of the QT interval and sudden cardiac death (Lasocka et al., 2021). In this study, citalopram was used to treat depression in a patient who had torsade de pointes during pacemaker battery depletion.

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Section: Discussionmentioning

confidence: 99%

“…Citalopram is a depression drug with a high cardiac safety profile (Straley et al, 2021 ). Therefore, it is widely used for the treatment of depression (Straley et al, 2021 ). However, it can induce QT interval prolongation.…”

Section: Discussionmentioning

confidence: 99%

Torsade de pointes caused by citalopram during the pacemaker battery‐depletion phase: A case report

Wang

Sun

Tao

2022

Noninvasive Electrocardiol

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“…We found 15 studies on the effect of SSRIs on the QT interval, conducted in the USA [44,70,71,80,93,94], Japan [73,95], the Netherlands [96,97], Denmark [65], France [98], Sweden [43], Germany [77]. Sample sizes varied from 1 clinical case [95,99] to 618450 [93] patients with mental disorders.…”

Section: Tetracyclic Antidepressantsmentioning

confidence: 99%

“…Sample sizes varied from 1 clinical case [95,99] to 618450 [93] patients with mental disorders. The age of the observed patients ranged from infancy [44] to 89 years [100]. All studies included male and female patients.…”

Section: Tetracyclic Antidepressantsmentioning

confidence: 99%

“…Eight studies conducted during the analyzed period confirmed the prolongation of the QTc interval when taking citalopram in both toxic [71,80] and therapeutic doses [44,78,96,98,106], with a dosedependent effect [69,70,73]. However, the authors of two studies did not find QTc prolongation in people over 60 years of age when taking citalopram [94,97].…”

Section: Tetracyclic Antidepressantsmentioning

confidence: 99%

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Role of Pharmacokinetics and Pharmacogenetics of Antidepressant-Induced Prolongation of the QT Interval and Torsade de Pointes in Patients with Mental Disorders

Shnayder,

Kidyaeva,

Vaiman

et al. 2023

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Antidepressants (ADs) include drugs of various pharmacological groups, which are mainly used for the treatment of mental disorders (major depressive disorder, obsessive-compulsive disorder, social phobia, panic disorder, generalized anxiety disorder, post-traumatic stress disorder), chronic pain and addiction diseases. Chronic use of ADs can lead to the development of cardiotoxic adverse drug reactions (ADRs). The most important cardiotoxic AD-induced ADRs are prolongation of the QT interval, ventricular tachycardia of the "pirouette" type (Torsades de Pointes - TdP). This narrative review analyzes and summarizes the results of studies on pharmacokinecis and pharmacogenetics of ADs on QT interval prolongation and updates physicians' knowledge of the risk of developing AD-induced TdP in patients with psychiatric disorders.

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Comparison of the effect of citalopram, bupropion, sertraline, and tricyclic antidepressants on QTc: A cross-sectional study

Cited by 2 publications

References 38 publications

Torsade de pointes caused by citalopram during the pacemaker battery‐depletion phase: A case report

Torsade de pointes caused by citalopram during the pacemaker battery‐depletion phase: A case report

Role of Pharmacokinetics and Pharmacogenetics of Antidepressant-Induced Prolongation of the QT Interval and Torsade de Pointes in Patients with Mental Disorders

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