Comparison of the Effect of Lidocaine versus a Lidocaine-Bupivacaine Combination in a Periprostatic Nerve Block Undergoing Transrectal Ultrasound-Guided Prostate Biopsy: A Double-Blind Randomized Controlled Trial

Abstract

Introduction: To determine whether a combination of the long acting local anesthetic, bupivacaine, and lidocaine is better than lidocaine alone in the long-term pain control, which is a short-acting anesthetic. Materials and Methods: In group 1, periprostatic nerve block was applied to both neurovascular areas with 2% lidocaine (5 ml) in an isotonic solution (5 ml). In group 2, the combination of 2% lidocaine (5 ml) and 5mg/ml bupivacaine (5 ml) was used for the PPNB. Results: In the first 30 minutes the mean VAS scores of groups 1 and 2 were 2.1 ± 0.2 and 1.2 ± 0.1, respectively (p = 0.002). VAS scores of group II determined at 1, 2, 4, 6, and 8 hours after the biopsy were significantly lower since it was (p < 0.05). Conclusion: While periprostatic nerve block for late phase pain control, applying a combination of a long-acting local anesthetic, such as bupivacaine, is effective in terms of pain control and patient comfort.

Narcotic Utilization After Cleft Lip Repair: Does Local Anesthetic Choice Matter?

“…34 Prospective double-blinded study in urologic patients demonstrated that a combination of lidocaine and bupivacaine was associated with significantly lower patient-reported pain scores at 1, 2, 4, 6, and 8 h postoperatively. 35 Another urologic study demonstrated that patients receiving the combination of bupivacaine and lidocaine experienced significantly less pain every subsequent day after their procedure. 36 Patients undergoing cleft lip surgery are usually admitted postoperatively and are discharged on the first postoperative day.…”

Effectiveness of periprostatic block to prevent pain in transrectal prostate biopsy: a systematic review and a network meta-analysis

“…Although transrectal ultrasound-guided (TRUS) prostatic biopsy has been considered a minor procedure, people often experience pain, anxiety and disturbances before, during and after the procedure [7]. About 65–90% of men experience pain based on different factors: entering an ultrasound probe in the rectum, the movement of this device, size and geometry of the probe, the insertion of the needle for injecting anesthetics, the biopsy itself, among others [6, 7, 8].…”