Comparison of the determination of the local tumor extent of primary endometrial cancer using clinical examination and 3 Tesla magnetic resonance imaging compared to histopathology

Brocker, Kerstin A.; Radtke, Jan Philipp; Hallscheidt, Peter; Sohn, Christof; Schlemmer, Heinz Peter; Alt, Céline D.

doi:10.1007/s00404-019-05072-5

Cited by 6 publications

(14 citation statements)

References 32 publications

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“…1,[5][6][7]10,14,17 In current study according to the gold standard, histopathological diagnostics, it is more common superficial MI (≤ 50%), which correlate with most reviewed studies and with fact that EC is detected at an early stage in most cases. [4][5][6][7][8][10][11][12]14,15,18,22,23 Several studies evaluated objective measurements such as those proposed by Gordon et al and Karlsson et al 2,3 Alcazar et al in systematic review and metaanalysis found that the overall diagnostic performance of TVUS for Karlsson's and Gordon's method in detecting deep MI in women with EC gave a pooled sensitivity of 84 % and 85 %, pooled specificity of 82% and 80% which is higher sensitivity and lower specificity than in our study for both methods. 2 They observed that both methods were similar, without statistical differences, in terms of diagnostic performance, similar as in our study.…”

Section: Discussionmentioning

confidence: 86%

“…Abdominal and pelvic MRI examination was composed of T2 and T1-weighted images and dynamic contrast-enhanced fat-suppressed images at 1.5 Tesla Avanto Siemens Medical Systems ® device, according to the dedicated MRI protocol of the European Society of Uro-Genital Radiologists since 2009 for the diagnosis of EC. 11 , 16 All study participants underwent abdominal and pelvic MRI examination within 10 days prior to surgery.…”

Section: Methodsmentioning

confidence: 99%

“…The surgeon was not blinded towards the histopathological diagnosis, TVUS and MRI results. 11 Surgery was performed by an open abdominal approach and according to the decision of the gynaecologic oncological interdisciplinary tumour board. The surgical approach was planned based on the FIGO classification derived from MRI.…”

Section: Methodsmentioning

confidence: 99%

“…The surgical approach was planned based on the FIGO classification derived from MRI. 11 The depth of MI obtained by TVUS and MRI has been correlated to help shed light on the dilemma of whether classical hysterectomy with bilateral adnexectomy is sufficient or pelvic lymphadenectomy is necessary for oncological treatment to be adequate.…”

Section: Methodsmentioning

confidence: 99%

“…3 TVUS when carried out by experienced hands has been shown to perform equally well as MRI, in the preoperative staging of EC. 4 Several studies, systematic review and metaanalyses compared subjective assessment and objective TVUS measurements techniques 2,5,6 , TVUS (subjective assessment) and MRI 3,[7][8][9][10][11] , three-dimensional TVUS and MRI 12 , and different MRI techniques. [13][14][15] However, to the best of our knowledge this is the first study that compared two objective TVUS measurements techniques (Gordon's and Karlsson's method) with MRI on the same set of patients.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial invasion in patients with endometrioid endometrial cancer: a prospective comparative study

Cerovac

Ljuca

Arnautalic

et al. 2022

Radiology and Oncology

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Background We compared the accuracy of preoperative transvaginal ultrasound (TVUS) versus magnetic resonance imaging (MRI) for the assessment of myometrial invasion (MI) in patients with endometrial cancer (EC), while definitive histopathological diagnosis served as a reference method. Patients and methods Study performed at a single tertiary centre from 2019 to 2021, included women with a histopathological proven EC, hospitalized for scheduled surgery. TVUS and MRI were performed prior to surgical staging for assessment MI, which was estimated using two objective TVUS methods (Gordon’s and Karlsson’s) and MRI. Patients were divided into two groups, after surgery and histopathological assessment of MI: superficial (≤ 50%) and deep (> 50%). Results Sixty patients were eligible for the study. According to the reference method, there were 34 (56.7%) cases in the study with MI < 50%, and 26 (43.3%) with MI > 50%. Both objective TVUS methods and MRI showed no statistical significant differences in overall diagnostic performance for the preoperative assessment of MI. The concordance coefficient between both TVUS methods, MRI and histopathology was statistically significant (p < 0.001). Gordon’s method calculating MI reached a positive predictive value (PPV) of 83%, negative predictive value (NPV) of 83%, 77% sensitivity, 88% specificity, and 83% overall accuracy. Karlsson’s method reached PPV of 82%, NPV of 79%, 69% sensitivity, 88% specificity, and 80% overall accuracy. Accordingly, MRI calculating MI reached PPV of 83%, NPV of 97%, 97% sensitivity, 85% specificity, and 90% overall accuracy. Conclusions We found that objective TVUS assessment of myometrial invasion was performed with a diagnostic accuracy comparable to that of MRI in women with endometrial cancer.

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Section: Discussionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial invasion in patients with endometrioid endometrial cancer: a prospective comparative study

Cerovac

Ljuca

Arnautalic

et al. 2022

Radiology and Oncology

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ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma

et al. 2021

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Initiated through ESGO the decision to develop multidisciplinary guidelines has been made jointly by the ESGO, ESTRO, and ESP. The ESGO has provided administrative support. The ESGO, ESTRO and ESP are nonprofit knowledgeable societies.The development group (including all authors) is collectively responsible for the decision to submit for publication. Nicole Concin (chair), Carien L. Creutzberg (cochair), Xavier Matias-Guiu (co-chair) and François Planchamp (methodologist) have written the first draft of the manuscript. All other contributors have actively given personal input, reviewed the manuscript, and have given final approval before submission.

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ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

Concin

Matías‐Guiu

Vergote

et al. 2021

Radiotherapy and Oncology

164

203

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A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines on selected questions. Given the large body of literature on the management of endometrial carcinoma published since 2014, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy & Oncology (ESTRO) and the European Society of Pathology (ESP) jointly decided to update these evidence-based guidelines and to cover new topics in order to improve the quality of care for women with endometrial carcinoma across Europe and worldwide. ESGO/ESTRO/ESP nominated an international multidisciplinary development group consisting of practicing clinicians and researchers who have demonstrated leadership and expertise in the care and research of endometrial carcinoma (27 experts across Europe). To ensure that the guidelines are evidence-based, the literature published since 2014, identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the

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Comparison of the determination of the local tumor extent of primary endometrial cancer using clinical examination and 3 Tesla magnetic resonance imaging compared to histopathology

Cited by 6 publications

References 32 publications

Efficacy of transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial invasion in patients with endometrioid endometrial cancer: a prospective comparative study

Efficacy of transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial invasion in patients with endometrioid endometrial cancer: a prospective comparative study

ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma

ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma

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