Comparison of the depth profiles of water and water-binding substances in the stratum corneum determined in vivo by Raman spectroscopy between the cheek and volar forearm skin: effects of age, seasonal changes and artificial forced hydration

Egawa, Mariko; Tagami, Hachiro

doi:10.1111/j.1365-2133.2007.08311.x

Cited by 207 publications

(209 citation statements)

References 29 publications

(60 reference statements)

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“…The water content at the outermost layer of SC is normally 15-20%, in dehydrated or xerotic skin, on the other hand, it is only 10% [9]. Water content in SC is not homogeneous -it increases from around 15-30% at the outermost layer of SC to around 70% in the deeper living layer, and it stays at around 70% deeper in epidermis and dermis [10].…”

Section: Skin Hydrationmentioning

confidence: 99%

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Saknīte

Zavorins

Zablocka

et al. 2017

JBPE

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Abstract. Diffuse reflectance spectroscopy system was developed for estimation of skin hydration in the near-infrared spectral range of 900-1700 nm. Experimental setup consisted of a near-infrared spectrometer, Y-type fiber optics probe with 1 detection and 6 illumination fibers, halogen-tungsten light source and a PC. By analyzing diffuse reflectance spectrum, a parameter representing skin hydration by performing baseline correction and calculating the area under the 1450 nm water absorption maximum is proposed. A clinical study was performed acquiring data of skin hydration of 39 patients' forearm skin. Results of the developed system are compared to results obtained by a commercial device based on skin conductance measurements. © 2017 Journal of Biomedical Photonics & Engineering.Keywords: Diffuse reflectance; near-infrared; spectroscopy; water; absorption; hydration; skin.

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Section: Skin Hydrationmentioning

confidence: 99%

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Saknīte

Zavorins

Zablocka

et al. 2017

JBPE

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“…A single technique that can measure both water content and SC thickness would be of great value as a clinical measurement device. In-vivo confocal Raman spectroscopy (CRS) has evolved as a single clinical measurement device capable of making both measurements based on the spectra of skin with depth into the SC before and after treatments [11,[16][17][18][19][20]. Although capable of providing SC thickness values, a consistent, reliable, SC thickness measurement from CRS has not emerged and of those methods that have been proposed, there is no agreement on best practices and no direct correlation with an established SC measurement method.…”

Section: Introductionmentioning

confidence: 99%

“…The SC thickness calculation is dependent on the nature of the water profile because the point of curvature inflection of the profile is used to estimate the bottom of the SC. A number of methods for modeling the profiles have been described in the literature [17][18][19]28]. However, these are based on a number of different methodologies.…”

Section: Introductionmentioning

confidence: 99%

A Consensus Modeling Approach for the Determination of Stratum Corneum Thickness Using In-Vivo Confocal Raman Spectroscopy

Hancewicz¹,

Xiao²,

Weissman³

et al. 2012

JCDSA

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The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function; 2) frequency of minimum model error for consensus vs. individual SC thickness values; and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R 2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).

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“…The SC consists of about 15 tightly stacked layers of flattened dead cells full of keratin, embedded in a lipidic intercellular matrix, mainly composed of ceramides, long-chain free fatty acids and cholesterol [1]. The water content of the SC is low, compared with viable tissues, and it is characterized by a gradient that increases from the skin surface to the viable epidermis [2][3][4][5][6][7]. Due to its peculiar structure and composition, the SC represents the main barrier against the penetration of exogenous substances and also against transepidermal water loss.…”

Section: Introductionmentioning

confidence: 99%

Interpretation of the human skin biotribological behaviour after tape stripping

Pailler-Mattéi

Guerret‐Piécourt

Zahouani

et al. 2011

J. R. Soc. Interface.

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The present study deals with the modification of the human skin biotribological behaviour after tape stripping. The tape-stripping procedure consists in the sequential application and removal of adhesive tapes on the skin surface in order to remove stratum corneum (SC) layers, which electrically charges the skin surface. The skin electric charges generated by tape stripping highly change the skin friction behaviour by increasing the adhesion component of the skin friction coefficient. It has been proposed to rewrite the friction adhesion component as the sum of two terms: the first classical adhesion term depending on the intrinsic shear strength, t 0 , and the second term depending on the electric shear strength, t elec . The experimental results allowed to estimate a numerical value of the electric shear strength t elec . Moreover, a plan capacitor model with a dielectric material inside was used to modelize the experimental system. This physical model permitted to evaluate the friction electric force and the electric shear strength values to calculate the skin friction coefficient after the tape stripping. The comparison between the experimental and the theoretical value of the skin friction coefficient after the tape stripping has shown the importance of the electric charges on skin biotribological behaviour. The static electric charges produced by tape stripping on the skin surface are probably able to highly modify the interaction of formulations with the skin surface and their spreading properties. This phenomenon, generally overlooked, should be taken into consideration as it could be involved in alteration of drug absorption.

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Comparison of the depth profiles of water and water-binding substances in the stratum corneum determined in vivo by Raman spectroscopy between the cheek and volar forearm skin: effects of age, seasonal changes and artificial forced hydration

Cited by 207 publications

References 29 publications

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

A Consensus Modeling Approach for the Determination of Stratum Corneum Thickness Using In-Vivo Confocal Raman Spectroscopy

Interpretation of the human skin biotribological behaviour after tape stripping

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