Comparison of the cyanogen bromide peptides of insoluble guinea-pig skin and scar collagen

The Chemistry and Biology of Collagen

“…The proportion of collagen types in dermal scar tissue differs from that in the surrounding skin (Shuttleworth et al, 1975;Barnes et al, 1976), a finding that may be important in understanding the process of wound repair. In pathologic fibrotic states, such as alcoholic liver cirrhosis (Rojkind and Martinez-Palomo, 1976) and idiopathic pulmonary fibrosis (Seyer et al, 1976), changes in the proportion of types I and III collagens, compared with normal tissues, have also been observed and may relate to the pathogenesis of the disorders.…”

“…It tends to occur in rapidly proliferating tissues and there is relatively less type III collagen in adult than in young animals. At present there is a divergence of opinion as to whether dermal scar-tissue collagen is predominantly composed of type I collagen (Shuttleworth et al, 1975) or contains type III collagen as the predominant component (Barnes et al, 1976). A substantial fraction of the al(III) chain has been sequenced (see Section V).…”

Granulocyte collagenase: selective digestion of type I relative to type III collagen.

“…The interstitial structure of many tissues includes two distinct collagens, termed types I and III (1,2). Not only is the relative proportion of the two types different in different tissues (3), but the ratio of type I to type III in the same tissues has been found to vary during development (2,4,5), in certain diseases (6,7), and in inflammation and repair (8)(9)(10). This is of general importance to organ function, because the relative proportion of the two collagen types appears to have a major influence on tissue mechanical properties.…”

Change in Vitreous Collagen after Penetrating Injury

“…Type I collagen has been observed in other areas of inflammation and wound healing, including lung and liver fibroplasia and dermal scars [15][16][17][18][19]. It has been sug gested that fibroblasts may cause traction of collagen fiber in scar tissues [20].…”