Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: and experimental study in rats

Schmiedl, Udo P.; Ogan, Marc D.; Moseley, Michael E.; Brasch, Robert C.

doi:10.2214/ajr.147.6.1263

Cited by 98 publications

(68 citation statements)

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“…Albumin-(GdDTPA) 30 , a prototype MMCM with a molecular weight of 92000 Daltons, was administered at a dose of 0.03 mmol Gd/kg. It demonstrates a volume of distribution that closely approximates plasma volume, 0.05 L/kg, and plasma half-life is approximately 3 hr, yielding nearly constant enhancement of blood and normal tissues for 30 min or longer after injection (14,21,22). Albumin-(GdDTPA) 30 has an R1 relaxivity of 19.6 s -1 mM -1 /Gd at 2 T and 37°C (21).…”

Section: Mr Contrast Mediamentioning

confidence: 99%

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Turetschek¹,

Floyd²,

Shames³

et al. 2001

Magnetic Resonance in Med

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The diagnostic potential of a new rapid clearance blood pool contrast medium (P792; MW ‫؍‬ 6.47 kDa) for the MR assessment of microvessel characteristics was assessed in 42 chemicallyinduced breast tumors, with comparisons to albumin-(Gd-DTPA). Microvessel characteristics, including the transendothelial permeability (K PS ) and the fractional blood volume (fPV), were estimated by using dynamic MR data fit to a bidirectional twocompartment model. The MR-derived estimates for K PS and fPV using each contrast agent were compared, and assays using each contrast agent were correlated to the histologic tumor grade (SBR score) and the microvascular density (MVD) counts. Using P792-enhanced data, neither K PS nor fPV showed a statistically significant correlation with the tumor grade or the MVD (P > .05). Conversely, using albumin-(GdDTPA) 30

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Section: Mr Contrast Mediamentioning

confidence: 99%

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Turetschek¹,

Floyd²,

Shames³

et al. 2001

Magnetic Resonance in Med

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“…However, the sensitivities of the current MRI probes are not sufficient to perform the clinical amyloid imaging, and those with increased sensitivities are urgently needed. Recently, macromolecular Gd(III) complexes based on albumin have been reported in some studies as blood-pool contrast agents with high relaxation performance (Schmiedl et al, 1986;Turetschek et al, 2001;Daldrup-Link et al, 2004;Rosen and Schnall, 2007;Wu et al, 2009). Most researches on the complex were only focused on its application in tumor angiogenesis imaging, but the ability of the complex to be modified to become specific probes has not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Detection of Aβ Plaques by a Novel Specific MRI Probe Precursor CR‐BSA‐(Gd‐DTPA)n in APP/PS1 Transgenic Mice

Cui

et al. 2010

The Anatomical Record

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Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The lack of specific probes that can detect individual senile plaques in AD has prompted the development of magnetic resonance imaging (MRI) probes. In this study, based on DTPA-gadolinium (III) and congo red (CR), a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n was successfully synthesized. Its ability to bind to amyloid plaques was evaluated by brain sections from APP/PS1 transgenic mice. Its specificity for Ab plaques was further demonstrated by immunohistochemistry (IHC) staining with the monoclonal antibody to the Ab protein. Meanwhile, the amyloid deposits detected by the CR-BSA-(Gd-DTPA)n were matched to the amyloid deposits detected by Ab specific antibody. We also found that a few amyloid-like deposits which was not detected by IHC. The findings indicated that the probe perhaps could detect the neurofibrillary tangles (NFT) similar to the effect of CR itself, and this will be verified in future experiments. The works suggested that the Ab protein-specific magnetic resonance contrast agent precursor CR-BSA-(Gd-DTPA)n can be used as a potential fluorescence and MR multi-modal imaging probe precursor to display individual senile plaques in AD. Anat Rec, 293:2136Rec, 293: -2143

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“…These factors further reduce the required dose, and allow for equilibrium phase imaging. Furthermore, lack of concomitant soft-tissue enhancement permits better visualization of small distal intraparenchymal vessel branches (13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

MR angiography with a new rapid‐clearance blood pool agent: Initial experience in rabbits

Ruehm

Christina

Violas

et al. 2002

Magnetic Resonance in Med

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The purpose of this study was to assess a new Gd-based macromolecular intravascular contrast agent (P792, Vistarem®; Laboratoire Guerbet, Aulnay sous Bois, France) for MR angiography (MRA). P792 is a macrocyclic gadolinium compound based on a gadoterate meglumine structure substituted by hydrophilic arms. In vitro imaging of phantoms containing varying concentrations of P792 and gadoterate meglumine (Gd-DOTA) was performed. In rabbits (N ‫؍‬ 5), arterial concentrations for P792 and Gd-DOTA were determined, and in vivo 3D MRA was performed. For gadolinium concentrations ranging from 200 to 3000 mol/l, in vitro imaging showed higher SNR values for P792 compared to Gd-DOTA. Determination of arterial Gd concentration showed comparable bolus phase curves for P792 and Gd-DOTA. With P792, higher concentrations were obtained due to a restricted diffusion into the interstitial space. P792 allowed acquisition of high-quality MR angiograms. Image quality was rated as superior for P792 in the post-bolus phase images. In conclusion, P792 appears to be well suited for highquality first-pass and equilibrium-phase MRA. The intravascular properties lead to an excellent signal in the vasculature, with limited background enhancement. Since the agent is rapidly renally excreted, it should be well suited for perfusion and permeability imaging. Contrast-enhanced MR angiography (MRA) has evolved into an accurate technique for the assessment of most vascular territories (1-7). The technique is based on the availability of high-performance gradient systems, and is capable of reducing data acquisition times sufficiently to collect an entire 3D data set during the arterial phase of intravenously administered extracellular contrast agents (8). The T 1 -shortening effect of gadolinium chelates allows select enhancement of the arterial lumen without depending on time-of-flight effects. This assures maximal contrast between the arterial lumen and surrounding tissues, and renders the technique less susceptible to flow-dependent artifacts.The extracellular nature of the paramagnetic gadolinium chelates leads to rapid diffusion into the extracellular fluid compartment, resulting in decreasing arterial signal intensity and concomitant enhancement within surrounding tissues. The short intravascular halflife requires optimal timing of the contrast bolus, and provides only a very limited time window for data collection during the arterial phase of the intravenously administered contrast bolus. Timing errors may render the examination suboptimal or nondiagnostic. Thus high contrast doses and fast injection rates are required to induce adequate T 1

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Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: and experimental study in rats

Cited by 98 publications

References 0 publications

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Assessment of a rapid clearance blood pool MR contrast medium (P792) for assays of microvascular characteristics in experimental breast tumors with correlations to histopathology

Detection of Aβ Plaques by a Novel Specific MRI Probe Precursor CR‐BSA‐(Gd‐DTPA)n in APP/PS1 Transgenic Mice

MR angiography with a new rapid‐clearance blood pool agent: Initial experience in rabbits

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