Comparison of the concentrating ability of the human salivary gland for bromine, iodine and technetium

Alexander, W. D.; Harden, R. McG.; Mason, David R.; Shimmins, J.; Kostalas, H.

doi:10.1016/0003-9969(66)90180-4

Cited by 18 publications

(3 citation statements)

References 3 publications

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“…3 (the average ofthree independent experiments), when C1-is replaced with gluconate, 99'TcO uptake into rat parotid cell aggregates is stimulated over threefold. Since physiological studies with salivary glands have indicated that 99mTcO-is handled in a manner analogous to radioiodide (7,8), we also attempted to study the effect ofreplacing C1-in HBSS-H with I-. Although we observed a significant inhibition of 99mTcO-uptake (75%) when C1-was replaced with I-in HBSS-H, we found that non- (16) and is quite similar to comparably characterized C1-co-transport mechanisms found in the shark rectal gland (17,18) and the rabbit thick ascending limb of Henle's loop (19).…”

Section: Resultsmentioning

confidence: 99%

“…99mTcJ4 is thought to act as a pseudohalide (6). Physiological studies with thyroid and salivary glands (4,7,8) (13). Briefly, after excision and mincing of parotid glands, the tissue was incubated with continuous agitation at 370C for 1 h in Hanks' balanced salt solution with 30 mM Hepes, pH 7.4 (HBSS-H, see Table I) containing collagenase (96 U/ml) and hyaluronidase (0.19 mg/ml).…”

Section: Introductionmentioning

confidence: 99%

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99mTc-pertechnetate uptake in parotid acinar cells by the Na+/K+/Cl- co-transport system.

Helman¹,

Turner²,

Fox³

et al. 1987

J. Clin. Invest.

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""Tc-Pertechnetate ("'rcO) has widespread clinical use in the diagnosis and evaluation of dysfunctions in many different tissues. However, despite the broad clinical application of this radionuclide, very little is known about the mechanism by which ""TcOi enters a cell. We report evidence here that ""'TcO4shares the Na+/K+/Cl co-transport system localized to the basolateral membrane of rat parotid acinar cells. " TcO. uptake by these cells was quite rapid (t1/2 30 s), was completely inhibited by the loop diuretics furosemide and bumetanide, and was markedly dependent on the presence of Na', K+, and Oin the extracellular medium. Relative to uptake measured in the presence of physiological extracellular salt concentrations (Hanks' salts), "'TcOj uptake was inhibited 80% by sodium replacement and 50% by potassium replacement. When Cl-was replaced with the physiologically inert anion gluconate a threefold stimulation in ""'TcO uptake resulted. These observations provide strong evidence that "'TcO4 can substitute for G-as a substrate for the Na+/K+/Cl-co-transporter and indicate that "'TcO4 uptake by salivary glands (e.g., as seen with salivary scintiscans), and possibly by a variety of other tissues, reflects the functional activity of this co-transport mechanism.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

99mTc-pertechnetate uptake in parotid acinar cells by the Na+/K+/Cl- co-transport system.

Helman¹,

Turner²,

Fox³

et al. 1987

J. Clin. Invest.

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“…Although these agents are concentrated by both the thyroid and salivary glands, only iodide is organified, and this occurs only in the thyroid gland . Moreover, in humans, the salivary glands have a greater affinity for iodide than for pertechnetate, attaining a salivary iodide :plasma iodide ratio which is twice that of the salivary pertechnetate :plasma pertechnetate ratio, independent of the salivary flow rate (Alexander et al, 1966).…”

Section: Radionuclidesmentioning

confidence: 99%

The role of radionuclide scanning in the evaluation of neoplasms of the salivary glands: A review

Schall

1971

Journal of Surgical Oncology

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Evaluation of neoplasms of the salivary glands is a challenging surgical problem since there is no reliable laboratory procedure to confirm the diagnosis o€ a tumor or to indicate its nature or extent. Radionuclide scanning of the salivary glands can be performed using T~~~"'-pertechnetate, which is actively concentrated by the glands a t the level of the intralobar ducts. This test does not appear capable of detecting lesions which are not evident rlinically. The only two types of tumors which give a consistent scan appearance are Warthin's tumor, which appears 'hot' relative to the surrounding tissue, and metastatic lesions, which are 'cold' or distort the normal portions of the gland. I n general, primary malignancies also appear 'cold,' but the mixed tumor has a highly variable appearance. This procedure is useful in evaluating the topographic relationships of salivary gland neoplasms and in differentiating them from neck or facial masses, as well as in determining the functional impairment of the glands caused by the tumor. The results with salivary gland scanning t o date have been somewhat disappointing, although the application of recent technologic advances in this field and standardization of the scanning technique in a large series of patients may eventually justify the initial optimism in this diagnostic study.

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Sodium Pertechnetate Tc 99m in Lacrimal Secretion

O'Nan¹,

Wirtschafter²,

Preston³

1974

Archives of Ophthalmology

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Comparison of the concentrating ability of the human salivary gland for bromine, iodine and technetium

Cited by 18 publications

References 3 publications

99mTc-pertechnetate uptake in parotid acinar cells by the Na+/K+/Cl- co-transport system.

99mTc-pertechnetate uptake in parotid acinar cells by the Na+/K+/Cl- co-transport system.

The role of radionuclide scanning in the evaluation of neoplasms of the salivary glands: A review

Sodium Pertechnetate Tc 99m in Lacrimal Secretion

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