1965
DOI: 10.1016/0005-2760(65)90049-4
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Comparison of the composition and surface activity of “alveolar” and whole lung lipids in the dog

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1971
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Cited by 164 publications
(52 citation statements)
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“…Lipid X2, one of acidic phospholipids, had a closely similar mobility to so called phosphatidyldimethylethanolamine reported by Morgan et al (1965) and by other investigators (Fujiwara et al 1968, Newman and Naimark 1968) on thin-layer chromatography with neutral solvent systems. However, it seemed to be phospha tidylglycerol since the deacylated product migrated with that of phosphatidylgly cerol separated from E. coli, and showed a mobility between X1 and X3 on thinlayer chromatography with basic solvent systems which was considered to be one of characteristics of acidic phospholipids.…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…Lipid X2, one of acidic phospholipids, had a closely similar mobility to so called phosphatidyldimethylethanolamine reported by Morgan et al (1965) and by other investigators (Fujiwara et al 1968, Newman and Naimark 1968) on thin-layer chromatography with neutral solvent systems. However, it seemed to be phospha tidylglycerol since the deacylated product migrated with that of phosphatidylgly cerol separated from E. coli, and showed a mobility between X1 and X3 on thinlayer chromatography with basic solvent systems which was considered to be one of characteristics of acidic phospholipids.…”
Section: Discussionsupporting
confidence: 77%
“…It has generally been accepted that so-called dipalmitoyllecithin, one of the molecular species of lecithin, in the lung and alveolar wash is the principal compo nent of the surfactant (Pattle 1958, Brown et al 1959, Klaus et al 1961, Avery 1959. Morgan et al (1965) reported that alveolar lipids in dog pulmonary wash contained significant amounts of phosphatidyldimethylethanolamine which might contribute to the formation of dipalmitoyllecithin with methyltransferase. How ever, several investigators have reported recently the presence of phosphatidyl glycerol and lyso-bis-phosphatidic acid, but they stated that they could not detect phosphatidyldimethylethanolamine in the alveolar wash.…”
mentioning
confidence: 99%
“…A significant increase of free fatty acid and triglyceride was observed in the lungs of 11-13th day old animals. Morgan et al (1965) reported that the lipid composition of whole lung from mature dogs contain 70.4% phospholipid, 12.6% cholesterol , 9.0% triglyceride and 3.2 cholesterol ester. The lipid composition of rat lungs does not agree with the data of dog lungs.…”
Section: Discussionmentioning
confidence: 99%
“…Whereas many phospholipids possess at least some surface activity, the most active fraction is thought to be dipalmityl phosphatidylcholine (12), which makes up an increasing proportion of the total phospholipid in lung lavage fluid with advancing gestation (9). The proportion of surface-active phospholipid in lung lavage fluid is significantly higher than in lung parenchyma (13). Although the measurement of total phospholipid in lung lavage fluid is a relatively crude index, there is good reason to believe it is representative of an important component of the pulmonary surfactant.…”
mentioning
confidence: 99%