Comparison of the clinicopathological characteristics of young and Elderly patients with gastric carcinoma: A meta analysis

Kong, Xuan; Wang, Jilin; Chen, Huimin; Fang, Jing‐Yuan

doi:10.1002/jso.23004

Cited by 76 publications

(79 citation statements)

References 34 publications

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“…Diffusely infiltrative tumors were also more common in young patients. As indicated in previous studies [7,9,10], well-differentiated, intestinal-type gastric cancer usually originates from intestinal metaplastic mucosa, whereas undifferentiated gastric cancer usually originates from gastric fundus glands. Therefore, undifferentiated rather than well-differentiated gastric cancer might be more likely to occur in young patients in whom atrophy of the gastric mucosa is uncommon.…”

Section: Discussionmentioning

confidence: 58%

“…One factor that has been cited as an indicator of poor prognosis of gastric cancer is early onset, i.e., that occurring in patients who are comparatively young [1][2][3][4]. Gastric cancer usually occurs in individuals aged 50-70 years [2,5,6] and is rare in the young [7][8][9]. Factors that contribute to the poor prognosis of gastric cancer in the young include delayed detection, resulting in an advanced stage at presentation, diffuse infiltration of the tumor and a poorly differentiated histology [1,4,10].…”

Section: Introductionmentioning

confidence: 99%

“…Factors that contribute to the poor prognosis of gastric cancer in the young include delayed detection, resulting in an advanced stage at presentation, diffuse infiltration of the tumor and a poorly differentiated histology [1,4,10]. On the other hand, recent studies have indicated that prognosis in young patients is equivalent to [7,11,12] or better than that in middle-aged patients with cancers at the same stage [8,9,13,14]. Thus, the concept of gastric cancer having a poorer prognosis in relatively young patients remains controversial.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological features of gastric cancer in young patients

et al. 2015

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Background Early-onset gastric cancer is relatively rare. To evaluate the clinicopathological features and surgical outcome of young patients with gastric cancer, this retrospective comparative study was conducted. Methods From 2000 to 2010, 4882 patients underwent surgery for gastric adenocarcinoma in our institution. A total of 136 patients under 40 years old were enrolled as the young group, and a total of 1435 patients aged between 60 and 69 were identified as the control group for this study. The patient's characteristics, pathological findings, surgical and clinical outcomes were reviewed, and the risk factors of recurrence were compared between the two groups. Results Among the young group, patients had significantly fewer comorbidities and postoperative complications. The patient proportion having 7 or more lymph node metastases was higher in the young group (25 %) than in the control group (16 %). The presence of lymph node metastasis was identified as a strong risk factor for recurrence (odds ratio = 4.31) in the young group according to the results of the step-wise logistic regression analysis. Although the disease-specific survival at stage II was relatively better in the young group (p = 0.0439) than in the control group, there were no significant differences in overall survival for all stages. Conclusion Early-onset gastric cancer is likely to present lymph node metastases. The survival rate of gastric cancer in young patients was equivalent to that in patients in their 60s, which is the typical age at onset.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological features of gastric cancer in young patients

et al. 2015

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“…On the other hand, the severity of mucosal inflammation and various host features may directly induce mutagenetic events that ultimately lead to the onset of the latter. Moreover, the diffuse type of GC develops in comparatively younger subjects (24). Therefore, we suspect that NFKB1 polymorphisms were significantly associated with susceptibility to GC in young subjects, not elder subjects, in the present study.…”

Section: Discussionmentioning

confidence: 59%

Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer

et al. 2013

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Abstract. In the present study, we report an association between gastric cancer and polymorphisms in NFKB1 (rs28362941 and rs78696119). We employed the PCR-SSCP method to detect gene polymorphisms in 479 gastric cancer cases and 880 controls. The rs28362941 del/del homozygote was significantly associated with gastric cancer development; in particular it was closely associated with diffuse type gastric cancer. The rs78696119 GG homozygote was also associated with the diffuse type of gastric cancer. In young subjects, both polymorphisms were significantly associated with the development of gastric cancer. In addition, both polymorphisms were related to tumor progression such as tumor invasion and lymph node metastasis. The inflammatory cell infiltration into non-cancerous gastric mucosa was greater in the subjects with the rs28362491 del/del or rs78696119 GG genotype when compared to those with the other genotypes. In conclusion, functional polymorphisms of NFKB1 are associated with an increased risk of gastric cancer; in particular they are closely associated with the development of diffuse type of gastric cancer via severe gastric inflammation. These polymorphisms also appear to be associated with gastric cancer progression.

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“…The biological and clinicopathological features of the Early Onset GAC (EOGAC) are remarkably distinct from the sporadic GAC of older patients, suggesting these to be distinct entities [63,64].…”

Section: Genetic and Genomics Aspectsmentioning

confidence: 99%

Genomics and epidemiology for gastric adenocarcinomas

2017

Appl Cancer Res

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Whereas the pathological aspects of Gastric Adenocarcinomas (GACs) have been well defined, the actual knowledge of its genesis and evolution remains to be translated to better diagnosis and to more effective therapeutics. As a consequence, the current treatment modalities are not yet able to modify the natural history of the disease, which still presents high mortality-rates worldwide. In this review we highlight the current status of relevant epidemiologic, therapeutic and genomics aspects of GACs and point to some of the current knowledge gaps that, if fully addressed, could contribute to a more effective treatment and better management of the patients that suffer from this often-lethal disease.

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Comparison of the clinicopathological characteristics of young and Elderly patients with gastric carcinoma: A meta analysis

Cited by 76 publications

References 34 publications

Clinicopathological features of gastric cancer in young patients

Clinicopathological features of gastric cancer in young patients

Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer

Genomics and epidemiology for gastric adenocarcinomas

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