Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients – a prospective observational study

Auvinen, Raija; Nohynek, Hanna; Syrjänen, Ritva; Ollgren, Jukka; Kerttula, Tuija; Mäntylä, Jarkko; Ikonen, Niina; Loginov, Raisa; Haveri, Anu; Kurkela, Satu; Skogberg, Kirsi

doi:10.1080/23744235.2020.1840623

Cited by 38 publications

(47 citation statements)

References 33 publications

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“…In this review, 14 studies of 18 [ 5 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 20 , 21 ] reported a comparison between COVID-19 and influenza patients based on demographic findings, comorbidities, clinical features, and outcome ( Table 2 ). Fever and respiratory symptoms such as cough, expectoration or sputum production and dyspnea were the main symptoms in both groups with COVID-19 and influenza; however, they were significantly more frequent in patients with influenza [ 5 , 9 , 10 , 11 , 13 , 15 , 16 , 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, vomiting, otorhinolaryngological symptoms such as nasal congestion, rhinorrhea, sore throat and ocular symptoms such as tearing and conjunctival hyperhemia were statistically more frequent in patients with influenza than COVID-19 adult patients [ 5 , 10 , 11 , 12 , 15 ]. In patients infected with COVID-19, the most significant and frequent clinical features were fatigue, neurologic symptoms such as headache (especially facial headache: retro-orbital or frontal headache), anosmia and dysgeusia, gastro-intestinal (GI) symptoms such as diarrhea and acute respiratory distress syndrome (ARDS), compared to influenza patients [ 11 , 13 , 14 , 15 , 18 ]. In a retrospective case-control study, Tang et al reported that patients with influenza were more disposed to have productive cough and higher Sequential Organ Failure Assessment (SOFA) scores (OR = 9.58, (95% CI = 1.73–64.72), p = 0.011 and OR = 2.26 (1.12–3.57), p = 0.006, respectively).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning comorbidities; cardiovascular disease/hypertension, diabetes and obesity were significantly higher in patients with COVID-19, while respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) and immunocompromised conditions were significantly more common in influenza patients [ 5 , 11 , 18 ]. Zayet et al concluded that COVID-19 patients had a lower Charlson comorbidity index (CCI) than influenza patients (2 ± 2.5 vs. 3 ± 2.4, respectively, p = 0.003), but with no significant differences regarding comorbidities [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…On PubMed, 331 articles were initially found, out of which 46 articles were selected. In the end, 18 articles were selected [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] (8 retrospective studies, 6 cohort studies, 3 casecontrol studies, 1 prospective study, 1 cross-sectional study, 1 review and meta-analysis, and 1 review) ( Figure 1 and Table 1) An outcome-free study population is first identified by the exposure/event of interest and followed in time until the outcome of interest happens. They can be prospective (carried out from the present time into the future) or retrospective (carried out at the present time and look to the past to examine medical events or outcome).…”

Section: Included Citations In the Covid-19 Vs Influenza Reviewmentioning

confidence: 99%

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A Comparative Systematic Review of COVID-19 and Influenza

Osman

Klopfenstein

Belfeki³

et al. 2021

Viruses

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Background: Both SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings. Methods: Literature search was done using PubMed to find MEDLINE indexed articles relevant to this study. As of 25 November 2020, the search has been conducted by combining the MeSH words “COVID-19” and “Influenza”. Results: Eighteen articles were finally selected in adult patients. Comorbidities such as cardiovascular diseases, diabetes, and obesity were significantly higher in COVID-19 patients, while pulmonary diseases and immunocompromised conditions were significantly more common in influenza patients. The incidence rates of fever, vomiting, ocular and otorhinolaryngological symptoms were found to be significantly higher in influenza patients when compared with COVID-19 patients. However, neurologic symptoms and diarrhea were statistically more frequent in COVID-19 patients. The level of white cell count and procalcitonin was significantly higher in influenza patients, whereas thrombopenia and elevated transaminases were significantly more common in COVID-19 patients. Ground-grass opacities, interlobular septal thickening, and a peripheral distribution were more common in COVID-19 patients than in influenza patients where consolidations and linear opacities were described instead. COVID-19 patients were significantly more often transferred to intensive care unit with a higher rate of mortality. Conclusions: This study estimated differences of COVID-19 and influenza patients which can help clinicians during the co-circulation of the two viruses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Included Citations In the Covid-19 Vs Influenza Reviewmentioning

confidence: 99%

See 2 more Smart Citations

A Comparative Systematic Review of COVID-19 and Influenza

Osman

Klopfenstein

Belfeki³

et al. 2021

Viruses

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“…Reviewing the literature we found few small -scale studies comparing laboratory parameters of adult patients with COVID- 19 and In uenza 32,42,43 and none compared with RSV. Only two studies investigated the NLR levels in COVID-19 compared to In uenza.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Prozan¹,

Shusterman²,

Ablin³

et al. 2020

Preprint

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Background: A high Neutrophil to Lymphocyte Ratio (NLR) is considered an unfavorable prognostic factor in various diseases, including COVID-19. The prognostic value of NLR in other respiratory viral infections, such as Influenza, has not hitherto been extensively studied. We aimed to compare the prognostic value of NLR in COVID-19, Influenza and Respiratory Syncytial Virus infection (RSV).Method: A retrospective cohort of COVID-19, Influenza and RSV patients admitted to the Tel Aviv Medical Center from January 2010 to October 2020 was analyzed. Laboratory, demographic, and clinical parameters were collected. Two way analyses of variance (ANOVA) was used to compare the association between NLR values and poor outcomes among the three groups. ROC curve analyses for each virus was applied to test the discrimination ability of NLR. Results: 722 COVID-19, 2213 influenza and 482 RSV patients were included. Above the age of 50, NLR at admission was significantly lower among COVID-19 patients (P<0.001). NLR was associated with poor clinical outcome only in the COVID-19 group. ROC curve analysis was performed; the area under curve of poor outcomes for COVID-19 was 0.643, compared with 0.497 and 0.537 for Influenza and RSV respectively. In the COVID-19 group, multivariate logistic regression identified a high NLR (defined as a value above 4.7) to be a prognostic factor for poor clinical outcome, after adjusting for age, sex and Charlson comorbidity score (odds ratio of 1.6, P=0.005). Conclusions: NLR at admission is lower and has more prognostic value in COVID-19 patients, when compared to Influenza and RSV.

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