Comparison of the clinical application of reactive oxygen species and inflammatory markers in patients with endocarditis

Abstract

IntroductionInfective endocarditis (IE) is still connected with high operative mortality. Inflammatory markers are commonly used in monitoring patient clinical condition. Respiratory burst and reactive oxygen species (ROS) are the main way of pathogen elimination. Specificity of this process in the aspect of bacterial infection is the key for correlation assessment between ROS and inflammatory markers in patients with IE. In the study, assessment of ROS as a clinical indicator in IE was conducted.Material and methodsDuring 2007/2008 in the Cardiosurgical Clinic of the Medical University in Lodz there were 20 patients operated on for IE. The examined population consisted of 13 men and 7 women, aged from 23 to 74 years. Inflammatory markers – leukocytosis (WBC), C-reactive protein (CRP), procalcitonin (PCT) and erythrocyte sedimentation rate (ESR) – were assessed preoperatively, on the 3rd, 7th, 12th and 21st day. Simultaneously, with the second venous blood sample chemiluminescence (luminal enhanced whole blood chemiluminescence) was carried out and used to assess ROS production. The results were analyzed statistically.ResultsPositive correlation between ESR, CRP and ROS in the preoperative period was confirmed. An increase in ROS and a statistically significant increase in inflammatory markers on the 3rd day were observed. The ROS normalized on the 12th day. Marked individual variability was specific for the inflammatory markers. Despite the significant decrease, not all of them achieved a normal level at the last control point.ConclusionsAssessment of ROS seems to be a universal parameter with possible application in patients with IE.

Lipoteichoic acid reduces antioxidant enzymes in H9c2 cells

“…Oxidative stress has been related to physiological processes like aging and atherosclerosis, cardiovascular diseases, cancer, diabetes mellitus and kidney damage [10]. In fact, Ostrowski et al [33] have proposed increased ROS production in IE as a clinical indicator. ROS production and inflammatory markers, including procalcitonin, C-reactive protein (CRP), leukocytosis and erythrocyte sedimentation rate (ESR), were evaluated on patients operated for IE.…”

“…ROS production and inflammatory markers, including procalcitonin, C-reactive protein (CRP), leukocytosis and erythrocyte sedimentation rate (ESR), were evaluated on patients operated for IE. Noteworthy, it was found a positive correlation between ESR, CRP, and ROS in the pre-operative period, indicating that ROS assessment could be a clinical parameter in patients with IE [33].…”

The effect of electromagnetic radiation emitted by display screens on cell oxygen metabolism – in vitro studies

“…In the opinion of other researchers, ROS level could be a universal indicator, which does not exclude the individualized approach in each episode of infective endocarditis (IE). The ROS may have a particular implication in high-risk patients, especially when the assays of inflammatory markers are confusing [ 11 ].…”

Baseline C-reactive protein levels and prognosis in patients with infective endocarditis: A prospective cohort study

“…Although serial monitoring of CRP levels is proven to have a role in predicting treatment outcomes, the value of CRP level at admission has been scantily studied 26, 27, 28. A biomarker that can help in early risk-stratification may guide decisions on treatment-aggressiveness 29 . The aim of the study was to examine whether estimation of serum CRP levels at admission, serves as a predictor of averse outcomes in IE.…”