Comparison of the Clinical and Biochemical Profile of Metabolic Syndrome Between Obese Children Below and Above 10 Years Old Attending Paediatric Clinic Hospital Universiti Sains Malaysia from 2006 to 2015

Abstract

Objectives. We aim to compare the clinical and biochemical profile of metabolic syndrome between obese children below and above 10 years attending Paediatric clinic Hospital Universiti Sains Malaysia (HUSM) from 2006 to 2015. This is to determine if age, particularly the transition to puberty, modifies the prevalence of components of metabolic syndrome in obese children. Results. Majority of subjects in both age groups were boys, with 68.2% <10 years old. Mean age was 9.69 years (±3.36). The clinical and biochemical parameters of metabolic syndrome were similar between those <10 years old and >10 years, with the exception of BMI, waist circumference, SBP and TG level. Multivariate regression analysis showed that the parameters of metabolic syndrome significantly associated with age ≥10 years were systolic hypertension (adjusted OR 7.17, 95% CI, 1.48 to 34.8) and BMI >30 kg/m 2 (adjusted OR 3.02, 95% CI, 1.16 to 7.86).Conclusion. There were similar clinical and biochemical parameters of metabolic syndrome in both age groups. The proportions of children with metabolic syndrome were similar regardless of age group. The overall prevalence rate of metabolic syndrome was 27.3%. In view of the alarming presence of components of metabolic syndrome even in children less than 10 years of age, efforts aimed at the prevention of childhood obesity in the community should be intensified.

TG: HDL-C Ratio as Insulin Resistance Marker for Metabolic Syndrome in Children With Obesity

“…Despite the high prevalence of abdominal obesity, less than 10% of the children had MetS. In contrast, a higher prevalence was reported among children with obesity in previous studies using the same MetS definition ( 52 , 53 ). Very recently, using IDF definition, Bitew et al.…”

“…Despite the high prevalence of abdominal obesity, less than 10% of the children had MetS. In contrast, a higher prevalence was reported among children with obesity in previous studies using the same MetS definition (52,53). Very recently, using IDF definition, Bitew et al (54) reported a pooled prevalence of MetS in low-and middle-income countries of 24.1% (95% CI: 16.90, 31.29) among children and adolescents with obesity.…”