Comparison of the CDC2-like kinase family across eukaryotes highlights the functional conservation of these unique biological thermometers
Rachel A. Ogle,
Jacob K. Netherton,
Benjamin R. Robinson
et al.
Abstract:The family of CDC2-like kinases (CLKs) play a crucial role in regulating alternative splicing (AS), a process fundamental to eukaryotic gene expression and adaptation. Of particular interest, these enzymes exhibit unique responsiveness to minor temperature shifts, enabling them to modulate AS accordingly. Dysregulated CLK expression is linked to a wide variety of human diseases, establishing them as promising therapeutic targets. Despite the importance of CLKs, limited research has explored the genetic and fun… Show more
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