Comparison of the cardiovascular system, clinical condition, and laboratory results in COVID-19 patients with and without vitamin D insufficiency

Kazemi, Erfan; Mansoursamaei, Ali; Rohani-Rasaf, Marzieh; Sheibani, Hossein

doi:10.1186/s12879-022-07438-8

Cited by 4 publications

(2 citation statements)

References 58 publications

(71 reference statements)

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“…U 127 osób występował niedobór tej witaminy, pozostałe posiadały prawidłowy wynik lub podwyższony. Wykazano, że ilość leukocytów, wartość odczynu Biernackiego (OB) oraz poziomu kinazy kreatynowej (CK-MB) jest wyższa w grupie osób z niedoborami witaminy D, ale różnica nie była istotna statystycznie [30].…”

Section: Wpływ Witaminy D Na Przebieg Infekcji Covid-19unclassified

Effect of vitamin D on the course of COVID-19 infection

Walczak

Patrycja

Sylwia

et al. 2023

J Educ Health Sport

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Introduction and purpose of work: COVID-19 is a disease caused by the SARS-CoV-2 virus. Vitamin D is categorized as a steroid hormone that affects the body's calcium-phosphate balance. It also exerts an immunomodulatory and anti-inflammatory function. Numerous studies indicate that vitamin D levels may have an impact on the course of COVID-19 infection. The purpose of this study is to describe the potential health benefits of vitamin D supplementation in COVID-19 patients. The literature available in the PubMed database was reviewed using the following keywords: "vitamin D"; "COVID-19 infection"; "SARS-Cov-2 virus". Stan wiedzy: Witamina D zmniejsza ryzyko ciężkiej ostrej infekcji górnych dróg oddechowych i COVID-19 poprzez jej wpływ na zmniejszenie replikacji wirusa, zmniejszenie produkcji cytokin prozapalnych i zwiększenie integralności komórek śródbłonka w drogach oddechowych. Stymuluje również syntezę katelicydyny i beta-defensyn. Białka, o których mowa, wykazują bezpośrednią aktywność przeciwwirusową. Część badań dowodzi, że niedobór witaminy D zwiększa śmiertelność, potrzebę inwazyjnej i nieinwazyjnej wentylacji u pacjentów z SARS-Cov-2-dodatnim. Udowodniono, że odpowiednia suplementacja omawianej witaminy zmniejsza ryzyko zakażenia COVID-19 nawet u osób wrażliwych. Wnioski: Wykazano, że obniżony poziom witaminy D zwiększa częstość występowania i nasilenie infekcji COVID-19. Istnieje potrzeba dalszych badań w celu potwierdzenia suplementacji witaminy jako skutecznej metody zapobiegania i łagodzenia infekcji wirusem SARS-Cov-2.

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Section: Wpływ Witaminy D Na Przebieg Infekcji Covid-19unclassified

Effect of vitamin D on the course of COVID-19 infection

Walczak

Patrycja

Sylwia

et al. 2023

J Educ Health Sport

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“…The vast majority of the available research indicates that SARS-CoV-2 infection prognosis and outcomes are better with sufficient concentrations of vitamin D, with or without supplementation [ 11 , 12 ]. However, some studies indicate that there are no significant differences based on vitamin D levels and/or that there are no improvements following supplementation [ 13 , 14 ]. Some people have even reported a lower rate of infection as a direct consequence of using the supplement in the past.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Analysis of Vitamin D Levels in Pregnant Women Diagnosed with Gestational Hypertension after SARS-CoV-2 Infection

Dahma

Craina

Dumitru

et al. 2023

JPM

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The great majority of existing studies suggests that the prognosis and outcomes of SARS-CoV-2 infections are improved with adequate vitamin D levels, with or without supplementation. Simultaneously, whether vitamin D supplementation during pregnancy lessens the chance of developing gestational hypertension is controversial. The objective of the present research was to evaluate whether vitamin D levels during pregnancy differ substantially among pregnant women who develop gestational hypertension following SARS-CoV-2 infection. The current research was designed as a prospective cohort following the pregnant women admitted to our clinic with COVID-19 until 36 weeks of gestation. Total vitamin D (25(OH)D) levels were measured in the three study groups in which pregnant women with COVID-19 during pregnancy and a diagnosis of hypertension after 20 weeks of gestation were considered the group of cases (GH-CoV). The second group (CoV) included those with COVID-19 and no hypertension, while the third group (GH) included those with hypertension and no COVID-19. It was observed that 64.4% of SARS-CoV-2 infections in the group of cases occurred during the first trimester, compared to 29.2% in the first trimester among the controls who did not develop GH. Normal vitamin D levels were measured at admission in a significantly higher proportion of pregnant women without GH (68.8% in the CoV group vs. 47.9% in the GH-CoV group and 45.8% in the GH group). At 36 weeks of gestation, the median values of 25(OH)D in the CoV group was 34.4 (26.9–39.7) ng/mL compared to 27.9 (16.2–32.4) ng/mL in the GH-CoV group and 29.5 ng/mL (18.4–33.2) in the GH group, while the blood pressure measurements remained over 140 mmHg among the groups who developed GH. There was a statistically significant negative association between serum 25(OH)D levels and systolic blood pressure (rho = −0.295; p-value = 0.031); however, the risk of developing GH was not significantly higher among pregnant women with COVID-19 if the vitamin D levels were insufficient (OR = 1.19; p-value = 0.092) or deficient (OR = 1.26; p-value = 0.057). Although insufficient or deficient vitamin D among pregnant women with COVID-19 was not an independent risk factor for the development of GH, it is likely that an association between first-trimester SARS-CoV-2 infection and low vitamin D plays a key role in developing gestational hypertension.

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