Comparison of the Cardiac MicroPET Images Obtained Using [¹⁸F]FPTP and [¹³N]NH₃ in Rat Myocardial Infarction Models

Abstract

The short half-life of current positron emission tomography (PET)

Emerging Tracers for Nuclear Cardiac PET Imaging

“…1. 18 F-labeled TPP derivatives are classified into three types (type 1, short aliphatic or ether form linkers are adopted between the triphenylphosphonium and 18 F; type 2, 18 F-substituted phenyl or benzyl group is attached to triphenylphosphine; and type 3, 18 Flabeled linkers are conjugated to triphenylphosphine derivatives by click chemistry) [30,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Among these cations, 4-18 F-fluorobenzyltriphenylphosphonium ( 18 F-FBnTP) showed promise for the first time as a myocardial perfusion PET agent.…”

“…Furthermore, 18 F-labeled TPP derivatives that have different functional groups, such as methyl, methoxy, tert-butyl, dimethyamine-substituted phenyl, and triazole formation, were investigated to assess their performance as MIA for PET [35,40,42,53]. ]FETMP), were investigated to assess the appropriate range of lipophilicity for myocardial imaging using PET [37][38][39][41][42][43][44]. Synthesis of [ 18 F]FATPs has been reported previously.…”

Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents

“…Therefore, radiolabeled TPP derivatives are promising candidates for myocardial imaging [19,20]. Table 1 shows the radiolabeled TPP derivatives that have been developed [15,16,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. The chemical structures of radiolabeled TPP derivatives are shown in Fig.…”

“…The defect size and contrast ratio of 13 N-NH 3 images at zero to three minutes were significantly lower than those at three to six minutes (P = 0.043), whereas 18 F-FATPs showed similar values for defect size and contrast ratio at zero to three and three to six minutes. The defect size for MI generated from microPET polar map imaging of 18 F-FPTP or 13 N-NH 3 was compared with 2,3,5-triphenyltetrazolium chloride (TTC) staining to measure the coefficient of determination [33]. The correlation coefficient between TTC staining and the polar map of 18 F-…”

Therapeutic Effect of Fimasartan in a Rat Model of Myocardial Infarction Evaluated by Cardiac Positron Emission Tomography with [18F]FPTP

“…To detect myocardial activity and evaluate the viability of myocardium, various imaging modalities, such as echocardiography, cardiac magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET) have been used, but each modality has its limitations: echocardiography is highly dependent on the echocardiographic windows and cutting plane, MRI cannot easily distinguish between epicardial fat layers and the myocardium and have limitations in evaluating myocardial perfusion, SPECT has low spatial resolution, and an unintended spread of the SPECT tracers to adjacent organs may compromise accurate diagnosis 2…”